DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rop and Stxbp2

DIOPT Version :9

Sequence 1:	NP_001261404.1	Gene:	Rop / 38493	FlyBaseID:	FBgn0004574	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_001344097.1	Gene:	Stxbp2 / 20911	MGIID:	107370	Length:	594	Species:	Mus musculus

Alignment Length:	601	Identity:	331/601 - (55%)
Similarity:	444/601 - (73%)	Gaps:	22/601 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MALKVLVGQKLMNEVVKYKPPPPKKQGVTSAAGAGGMEWRVLVVDKLGMRMVSACTKMHEISAEG 65
            :.||.:||:|:::.|::    ..||.|          ||:||::|...||::|:|.||.:|.|||
Mouse     4 LGLKAVVGEKILSGVIR----SVKKDG----------EWKVLIMDHPSMRILSSCCKMSDILAEG 54

  Fly    66 ITLVEDINKKREPLPTMDAIYLITPSDESVRGLIRDFENPARPMYRYAHVFFTEVCPEELFNDLC 130
            ||:||||||:|||:|:::||||::|:::||:.||.||:......|:.||:|||:.|||.||::|.
Mouse    55 ITIVEDINKRREPIPSLEAIYLLSPTEKSVQALIADFQGTPTFTYKAAHIFFTDTCPEPLFSELG 119

  Fly   131 KSCAAGKIKTLKEINIAFLPYECQVFSLDSPDTFQCLYSPAFASIRSKHIERIAEQIATLCATLG 195
            :|..|..:||||||::||||||.||||||:|.:...||.|..|..|.:.::.:|:|||||||||.
Mouse   120 RSRLAKAVKTLKEIHLAFLPYEAQVFSLDAPHSTYNLYCPFRAGERGRQLDALAQQIATLCATLQ 184

  Fly   196 EYPNVRYRSDWDRNIDLAASVQQKLDAYKADDATMGEGPEKARSQLLILDRGFDCVSPLLHELTL 260
            |||::|||...:....||.:|..||:|:|||..::||||||.||||||:||..|.|||||||||.
Mouse   185 EYPSIRYRKGPEDTAQLAHAVLAKLNAFKADTPSLGEGPEKTRSQLLIMDRAADPVSPLLHELTF 249

  Fly   261 QAMAYDLLPIVNDVYRY-TPGPNQP-DKEVLLDENDDLWVELRHEHIAVVSTQVTQNLKKFTDSK 323
            ||||||||.|..|.||| |.|.::. :|.|||||:|||||||||.|||.||.:||:.||.|.:||
Mouse   250 QAMAYDLLDIEQDTYRYETTGLSESREKAVLLDEDDDLWVELRHMHIADVSKKVTELLKTFCESK 314

  Fly   324 RMGSADKSSMRDLSQMIKKMPQYQKELSKYSTHLHLAEDCMKSYQNYVDKLCRVEQDLAMGTDAE 388
            |: :.||::::|||.::||||||||||:|||||||||:||||.::..|:|||.||||||||:|||
Mouse   315 RL-TTDKANIKDLSHILKKMPQYQKELNKYSTHLHLADDCMKHFKGSVEKLCSVEQDLAMGSDAE 378

  Fly   389 GEKIKDHMRNIVPILLDANVSNYDKVRIIALYVMIKNGISEENLTKLFTHAQLSPKDQDMVRNLS 453
            ||||||.|:.|||:||||:|..|||:|::.||::::||:|||||.||..||.:. ....::|||.
Mouse   379 GEKIKDAMKLIVPVLLDASVPPYDKIRVLLLYILLRNGVSEENLAKLIQHANVQ-SYSSLIRNLE 442

  Fly   454 CLGINVIADSRKKQYS-VPRKERTTESTYQMSRWTPVIKDIMEDCIEDKLDLRHFPFLEGRAQ-N 516
            .||..|...:.....| :.|:|| .|.|||:|||:|||||:|||.:||:||.:.:||:...|. .
Mouse   443 QLGGTVTNSAGSGTSSRLERRER-MEPTYQLSRWSPVIKDVMEDVVEDRLDRKLWPFVSDPAPVP 506

  Fly   517 TNYHAPTSARYGHWHKDKGQAQVKNVPRLIVFIVGGVSMSEMRCAYEVTNAVR-NWEVLVGSSHI 580
            ::..|.:|||:|||||:|...:.:..|||||:|||||:|||||.|||||.|.. .||||:|||||
Mouse   507 SSQAAVSSARFGHWHKNKAGVEARAGPRLIVYIVGGVAMSEMRAAYEVTRATEGKWEVLIGSSHI 571

  Fly   581 LSPEIFLSDLGSLSKE 596
            |:|..||.||.:|.::
Mouse   572 LTPTRFLDDLKTLDQK 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rop	NP_001261404.1	Sec1	40..583	CDD:395791	314/547 (57%)
Stxbp2	NP_001344097.1	Sec1	29..574	CDD:307231	314/547 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53928
OrthoDB	1	1.010	-	-		D289675at33208
OrthoFinder	1	1.000	-	-		FOG0000914
OrthoInspector	1	1.000	-	-		otm43538
orthoMCL	1	0.900	-	-		OOG6_100816
Panther	1	1.100	-	-	O	PTHR11679
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2284
SonicParanoid	1	1.000	-	-		X527
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.820