Protein Alignment Rop and unc-18

DIOPT Version :9

• Sequence 1: NP_001261404.1
• Gene: Rop / 38493
• FlyBaseID: FBgn0004574
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_001024606.1
• Gene: unc-18 / 181030
• WormBaseID: WBGene00006757
• Length: 591
• Species: Caenorhabditis elegans
• Alignment Length: 600
• Identity: 346/600 - (57%)
• Similarity: 461/600 - (76%)
• Gaps: 18/600 - (3%)

  Fly     1 MALKVLVGQKLMNEVVKYKPPPPKKQGVTSAAGAGGMEWRVLVVDKLGMRMVSACTKMHEISAEG 65
            |:||.:||.||:|:|::    |.||       |.|...|.||:||.|.|||:|:|.|||.|..||
 Worm     1 MSLKQIVGHKLLNDVIR----PLKK-------GDGRSAWNVLIVDTLAMRMLSSCCKMHNIMEEG 54

  Fly    66 ITLVEDINKKREPLPTMDAIYLITPSDESVRGLIRDFENPARPMYRYAHVFFTEVCPEELFNDLC 130
            ||:|||:||:||||||::|||||.|:.||:..||:|:  .||.:|:.|||||||.|.::||:.|.
 Worm    55 ITIVEDLNKRREPLPTLEAIYLIAPTAESIDKLIQDY--CARNLYKCAHVFFTEACSDQLFSTLS 117

  Fly   131 KSCAAGKIKTLKEINIAFLPYECQVFSLDSPDTFQCLYSPAFASIRSKHIERIAEQIATLCATLG 195
            ||.||..|||||||||||.|||.|||:|||||||...|:.......:.::|||||||||:|||||
 Worm   118 KSAAARFIKTLKEINIAFTPYESQVFNLDSPDTFFLYYNAQKQGGLTSNLERIAEQIATVCATLG 182

  Fly   196 EYPNVRYRSDWDRNIDLAASVQQKLDAYKADDATMGEGPEKARSQLLILDRGFDCVSPLLHELTL 260
            |||::|||:|::||::|...|:||||||||||.:||||.:||||||:|:|||:|.::||||||||
 Worm   183 EYPSLRYRADFERNVELGHLVEQKLDAYKADDPSMGEGADKARSQLIIIDRGYDAITPLLHELTL 247

  Fly   261 QAMAYDLLPIVNDVYRYTPGPNQP--DKEVLLDENDDLWVELRHEHIAVVSTQVTQNLKKFTDSK 323
            |||.||||.|.||||:|..|.:..  :||||||||||||||:||:||||||.:||:|||||::||
 Worm   248 QAMCYDLLGIENDVYKYETGGSDENLEKEVLLDENDDLWVEMRHKHIAVVSQEVTKNLKKFSESK 312

  Fly   324 -RMGSADKSSMRDLSQMIKKMPQYQKELSKYSTHLHLAEDCMKSYQNYVDKLCRVEQDLAMGTDA 387
             ..|:.|..|::|||.:||:|||::|||:|:|||:.|||:|||.||..|||||:|||||:.|.||
 Worm   313 GNKGTMDSKSIKDLSMLIKRMPQHKKELNKFSTHISLAEECMKQYQQGVDKLCKVEQDLSTGIDA 377

  Fly   388 EGEKIKDHMRNIVPILLDANVSNYDKVRIIALYVMIKNGISEENLTKLFTHAQLSPKDQDMVRNL 452
            |||:::|.|:.:||:|:|..|...|::|:|.||::.||||::|||.||..||.:|..|::.:.|.
 Worm   378 EGERVRDAMKLMVPLLIDPAVRCEDRLRLILLYILSKNGITDENLNKLLQHANISMADKETITNA 442

  Fly   453 SCLGINVIADS-RKKQYSVPRKERTTESTYQMSRWTPVIKDIMEDCIEDKLDLRHFPFLEGRAQN 516
            :.||:|::.|: |||.::..:|||..|..||.|||.||||||:||.|:::||.:|||||.||..|
 Worm   443 AYLGLNIVTDTGRKKTWTPTKKERPHEQVYQSSRWVPVIKDIIEDAIDERLDTKHFPFLAGRQVN 507

  Fly   517 TNYHAPTSARYGHWHKDKG-QAQVKNVPRLIVFIVGGVSMSEMRCAYEVTNAVRNWEVLVGSSHI 580
            ..|.||.|||||.|||::| |:..::.||||::|:|||:.||||..||||.|.:.|||::||..|
 Worm   508 QGYRAPASARYGQWHKERGQQSNYRSGPRLIIYIIGGVTFSEMRACYEVTAARKPWEVVIGSDRI 572

  Fly   581 LSPEIFLSDLGSLSK 595
            ::|:.||::|..|:|
 Worm   573 ITPDKFLTNLRDLNK 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rop	NP_001261404.1	Sec1	40..583	CDD:395791	325/547 (59%)
unc-18	NP_001024606.1	Sec1	30..575	CDD:279352	325/546 (60%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156562
Domainoid	1	1.000	669	1.000	Domainoid score	I66
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2382
Inparanoid	1	1.050	684	1.000	Inparanoid score	I361
Isobase	1	0.950	-	0	Normalized mean entropy	S1338
OMA	1	1.010	-	-		QHG53928
OrthoDB	1	1.010	-	-		D289675at33208
OrthoFinder	1	1.000	-	-		FOG0000914
OrthoInspector	1	1.000	-	-		oto19032
orthoMCL	1	0.900	-	-		OOG6_100816
Panther	1	1.100	-	-	LDO	PTHR11679
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2284
SonicParanoid	1	1.000	-	-		X527
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.890