DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ens and map7d1b

DIOPT Version :9

Sequence 1:	NP_001097498.1	Gene:	ens / 38491	FlyBaseID:	FBgn0264693	Length:	1241	Species:	Drosophila melanogaster
Sequence 2:	XP_005173803.1	Gene:	map7d1b / 796270	ZFINID:	ZDB-GENE-080215-23	Length:	770	Species:	Danio rerio

Alignment Length:	1092	Identity:	232/1092 - (21%)
Similarity:	343/1092 - (31%)	Gaps:	463/1092 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 ISASEDDSQASKDREEKLKYARDRQNEERHRKIEELRAQAEAAQRYREQKEEERRRRIEEIRTRD 126
            :|:.:...||.|.|||:.||...|..|:..:|.:.|..: |.|:|.||.:.|||||::||.|.:.
Zfish    90 VSSEQRQKQAKKRREERAKYLEQRTQEQAAKKAQWLEKE-EKARRLRESQLEERRRKLEEQRLKT 153

  Fly   127 TEKRHQVEERKKAIFEAEKERREYILKKNQERESRIEVKKRDRNSIGFAFGSSTPRLLDVPADYG 191
            .::|..:||:::...|..|||.|..:|::.::.
Zfish   154 EKRRALLEEKQRQKLEKNKERYESAIKRSTKKT-------------------------------- 186

  Fly   192 LVSPSAFWGQRRSTSISNVAGASLTRRSSERELADSGAKKRASSSTDRQDDHRRKSSSMYEVFNW 256
                   |.:.|....|...|.:.|   |.||       .|.|:||
Zfish   187 -------WAEIRQQRWSWAGGLNQT---SRRE-------SRCSAST------------------- 215

  Fly   257 GYSNDEPPKRFSLSIAGSEINIDGPANPHPPPTSKQTANAHRPTNLTTTTATSTTTAGHNNFNNN 321
                               :|:        |..::...|    ..|:.::||..
Zfish   216 -------------------VNL--------PRQTEPVIN----NRLSKSSATLW----------- 238

  Fly   322 NSYRKEDSVDSSPMVFRSVYRRKTDLMPTIPSPRDGHYGSRGSLSSTPARTPGRAYSMNRLDQLA 386
            ||..:..|:..||...|.|.|..|   ||:
Zfish   239 NSPCRTRSLRLSPWESRIVERLMT---PTL----------------------------------- 265

  Fly   387 QPIRRNGEHMRAILERERRERELEMLDETASLGGGGGRRGAGSSARARRAGSAGSGSSSAAGIMS 451
                       :.|.|.|                                        |.|.:.:
Zfish   266 -----------SFLARSR----------------------------------------SVATLQN 279

  Fly   452 RSMTHLAGGGGQRERGKYSLGGGISTSFRPLASGAGGQRDSTSKSMTQISSWSVYGSTAPQQPPP 516
            .|..|      |..|         |.|..||...:.........:    ..|.|..||    |..
Zfish   280 SSDPH------QCSR---------SASVSPLTPCSHHHHPHQHSA----ERWRVSAST----PDI 321

  Fly   517 NHLHHLRQSTLGLQTAATKKYLQSSFASASSFNSASFRANATGRGRQQQYAISTNPHRFLDLDPN 581
            ....|.|.||    ....||..:......:....::.......:.||.|....|.    .:..||
Zfish   322 TQRQHRRNST----PFEKKKKEKKDKERENEKEKSALSKEKVEKKRQSQSVTRTK----TEASPN 378

  Fly   582 SLLLMNSASLLVNAGSR-SGNATPGGHFNNSRPGSAMSTSTNMSTSGLVPRRPATAPRKPRPASI 645
                       |.|.:| |..|||     .|||              |.| .||.:   |:|:|.
Zfish   379 -----------VKAKNRASSPATP-----RSRP--------------LSP-NPAVS---PKPSSS 409

  Fly   646 AGTGMSLEEINKLKRDQKPPVKTTAASPSAQTTPKRTANLMSTSLIVTSSSSRLSSAEKKTPSKR 710
            :|               :.|       |..:|.|||.                      :||::.
Zfish   410 SG---------------RTP-------PGTKTRPKRA----------------------QTPARV 430

  Fly   711 EPPVPKAASASKALPSRTASSERISRLTKEPKTKDTSAMTRSMIVTSSSTSTITKPAPAPVAPTS 775
            :.|...|.:.....|          |..:.||...|:::...:.|:|:..:.::..||..|||
Zfish   431 QAPAVAAVTVETKEP----------RQPEPPKDTKTASIVPDITVSSAPATPLSPSAPITVAP-- 483

  Fly   776 APVPEQNGVAKEVEKTTADEPVPEAEVPTEAPVVVPSVSKAEKEALNTEKTEEGARQEEEQILAV 840
                                         :.|.||.:.|.:.:..
Zfish   484 -----------------------------QTPEVVNAASTSSRSL-------------------- 499

  Fly   841 ESVPEALVTSINVEEKSDEGNEKEVPKPQEQAAPKKPSRSKENSEVRELTPPEGADLMTASMMAK 905
                                      .|:...|..||:..
Zfish   500 --------------------------SPEPNTAISKPTAG------------------------- 513

  Fly   906 KITTEEEAKAALAERRRLAREEAERQAELERQRLEAER-LAEIKAQEEEAERQRLFEEESTRLAE 969
             .|..|||...|||:||.|||:.|::.:..|::.:..| |.|...:.||.||:|. :||:..:||
Zfish   514 -TTDPEEAARVLAEKRRQAREQREKEEQERREQEQRSRALREEHLRREEEERRRR-DEEAKLMAE 576

  Fly   970 EQRRGEEERLRKAIEEAQQREEEEKRRREEEEKQRV--EREEAEKKAKEEAEKQRVEVAERLKRE 1032
            :||..||            :|.:|:.|.|.||..|:  :|||||.||||||||||:|..:..::|
Zfish   577 QQRLQEE------------KEAQERARAEHEENLRLQKQREEAESKAKEEAEKQRIEREKHFQKE 629

  Fly  1033 EKEREERRKRVEAIMLRTRKGGAATTPSKDANDKAAPAATAPENNSSSNSSV----------TGS 1087
            |:||.||:||:|.||.||||..|..  .||..       |:.:.|.....||          ||:
Zfish   630 EQERLERKKRLEEIMKRTRKSDAGA--QKDVK-------TSTQVNGRVTDSVIKKNPSEALHTGA 685

  Fly  1088 SNNSAEGSPSAADSTP----APTATETVQEAPNSQAMYEQSVLDKENSLINS 1135
            :|.|...|.| .|:.|    ||........:.|..|...:.::...|...||
Zfish   686 TNQSPMSSVS-WDAAPVINGAPPTKHQNGLSSNGDAADFEEIIKLSNHSGNS 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ens	NP_001097498.1	MAP7	920..1060	CDD:283355	62/142 (44%)
map7d1b	XP_005173803.1	GBP_C	<94..173	CDD:303769	29/79 (37%)
		SWIRM-assoc_2	<357..>423	CDD:293105	28/125 (22%)
		MAP7	504..657	CDD:283355	72/193 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576676
Domainoid	1	1.000	91	1.000	Domainoid score	I7653
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15073
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.030