DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ens and map7d1a

DIOPT Version :9

Sequence 1:	NP_001097498.1	Gene:	ens / 38491	FlyBaseID:	FBgn0264693	Length:	1241	Species:	Drosophila melanogaster
Sequence 2:	XP_021322394.1	Gene:	map7d1a / 565172	ZFINID:	ZDB-GENE-060503-22	Length:	785	Species:	Danio rerio

Alignment Length:	1128	Identity:	232/1128 - (20%)
Similarity:	375/1128 - (33%)	Gaps:	464/1128 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 APAKISGCSAGATLHWFAQVGGQISASEDDSQASKDREEKLKYARDRQNEERHRKIEELRAQAEA 103
            :||:.||     :||  .:..| :...|...||.:.||||.||...|...:..:|.:.|..: |.
Zfish    74 SPARSSG-----SLH--PKKDG-MKYDERQKQAKERREEKAKYLEQRSQTQAAKKSQWLEKE-ER 129

  Fly   104 AQRYREQKEEERRRRIEEIRTRDTEKRHQVEERKKAIFEAEKERREYILKKNQERESRIEVKKRD 168
            |::.|||:.|||||::||.|.:...:|.::|:|:|...|..|||.|..:::: .:::..|::::.
Zfish   130 ARQVREQQLEERRRKLEEQRLKAERRRAELEDRQKQKLEKNKERYEAAIQRS-GKKTWAEIRQQR 193

  Fly   169 RNSIGFAFGSSTPRLLDVPADYGLVSPSAFWGQRRSTSISNVAGASLTRRSSERELADSGAKKRA 233
            .:..|...|:|:                      :|.|..:::..:|.:.      .||...||.
Zfish   194 WSWAGGLSGNSS----------------------QSQSRCSISAVNLPKH------VDSVINKRL 230

  Fly   234 SSSTDRQDDHRRKSSSMYEVFNWGYSNDE----------PPKRFSLSIAGSEINIDGPANPHPPP 288
            |.|:....:...::.|: ::..|..|..:          ...|.:.|:..:..:...|..|....
Zfish   231 SKSSATLWNTPSRTRSL-QLSPWESSIVDRLMTPTLSFLARSRSAASVLNNSRDAQSPLCPRSAS 294

  Fly   289 TSKQTANAHRPTNLTTTTATSTTTAGHNNFNNNNSYRKEDSVDSSPMVFRSVYRRKTDLMPTIPS 353
            .|..:..||||...:.....:|:|.                         .:.:|:.|
Zfish   295 ASPLSVCAHRPHRCSERWRVTTSTP-------------------------DITQRRRD------- 327

  Fly   354 PRDGHYGSRGSLSSTPARTPGRAYSMNRLDQLAQPIRRNGEHMRAILERERRERELEMLDETASL 418
                         |||                              |.::::::|
Zfish   328 -------------STP------------------------------LRKDKKDKE---------- 339

  Fly   419 GGGGGRRGAGSSARARRAGSAGSGSSSAAGIMSRSMTHLAGGGGQRERGKYSLGGGISTSFRPLA 483
                                                         ||..|
Zfish   340 ---------------------------------------------RENEK--------------- 344

  Fly   484 SGAGGQRDSTSKSMTQISSWSVYGSTAPQQPPPNHLHHLRQSTLGLQTAATKKYLQSSFASASSF 548
                 :::|.:|                                       :|.|:.
Zfish   345 -----EKNSITK---------------------------------------EKVLKK-------- 357

  Fly   549 NSASFRANATGRGRQQQYAISTNPHRFLDLDPNSLLLMNSASLLVNAGSRSGNATPGGHFNNSRP 613
                         ||...:|.|.    ::..|:.:..:.|||
Zfish   358 -------------RQSMPSIKTR----IESSPSPVFKLRSAS----------------------- 382

  Fly   614 GSAMSTSTNMSTSGLVPRRPATAPRKPRPASIAGTGMSLEEINKLKRDQKPPVKTTAASPSAQTT 678
                               |||.                              |...:|||...:
Zfish   383 -------------------PATP------------------------------KARVSSPSPAVS 398

  Fly   679 PKRTANLMSTSLIVTSSSSRLSSAEKKTPSKREPPVPKAASASKALPSRTASSERISRLTKEPKT 743
            ||..|                :.|...||..|    ||.|.....:.:||||...|.|: :||:.
Zfish   399 PKPPA----------------AQASPMTPKAR----PKRARTPARVETRTASPVAIDRV-REPRR 442

  Fly   744 KDTSAMTRSMIVTSSSTSTITKPAPAPVAPTSAPVPEQNGVAKEVEKTTADEPVPEAEVP-TEAP 807
            ..|....:.:|......|..        ||.|:|||      ..|..:..|.|      | |.||
Zfish   443 PATPEQPKILIFPPLRFSVF--------APASSPVP------SIVVSSVLDTP------PVTSAP 487

  Fly   808 VVVPSVSKAEKEALNTEKTEEGARQEEEQILAVESVPEALVTSINVEEKSDEGNEKEVPKPQEQA 872
            :|..|.|...:::                 ..|.::|:  |:|               |.|
Zfish   488 MVSVSASPVPEDS-----------------PLVSALPQ--VSS---------------PAP---- 514

  Fly   873 APKKPSRSKENSEVRELTPPEGADLMTASMMAKKITTEEEAKAALAERRRLAREEAERQAELERQ 937
            :|.||.....|                          .|||...|||:||.|||:.|::.|..|:
Zfish   515 SPGKPMAGTNN--------------------------PEEATRILAEKRRQAREQREKEEEERRE 553

  Fly   938 RLEAERLAEIKAQEEEAERQRLFEEESTRLAEEQRRGEEERLRKAIEEAQQREEEEKRRREEEEK 1002
            :||.||:...:...:|||.::..|||:..:||:::..||.|   .::|.:...|..|..:||.|:
Zfish   554 QLERERIQREERLVQEAEERKRREEEARLMAEQEKLREEAR---RLQEEEAALERAKIEQEENER 615

  Fly  1003 QRVEREEAEKKAKEEAEKQRVEVAERLKREEKEREERRKRVEAIMLRTRKGGAA-----TTPS-- 1060
            .:.::||||.||||||||||:|..:..::||:||.||:||:|.||.||||..||     |:|:
Zfish   616 LQKQKEEAETKAKEEAEKQRLEREKHFQKEEQERLERKKRLEEIMKRTRKTDAAEKKDSTSPAQV 680

  Fly  1061 --KDANDKAAPAATAPE--------NNSSSNSSVTGSSNNSAEGSPSAADSTPAPTATETVQEAP 1115
              ||:....|.|...|.        |.|.|...:.|...:..|...||....   :..|.:.:..
Zfish   681 NGKDSEMNKAAADYQPNTALKQDGVNESLSVPVLNGIQTSKHENGLSAKGEA---SQFEEILQLS 742

  Fly  1116 NSQAMYEQSVLDKENSLINSFST 1138
            |.....|:|..|:.:..|.:|.:
Zfish   743 NHNNGREKSESDRPDEPIMAFES 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ens	NP_001097498.1	MAP7	920..1060	CDD:283355	62/144 (43%)
map7d1a	XP_021322394.1	DUF3552	92..>179	CDD:330423	34/87 (39%)
		Atrophin-1	<287..519	CDD:331285	82/596 (14%)
		MAP7	513..673	CDD:310345	72/192 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576673
Domainoid	1	1.000	91	1.000	Domainoid score	I7653
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15073
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.030