DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ens and MAP7D1

DIOPT Version :9

Sequence 1:	NP_001097498.1	Gene:	ens / 38491	FlyBaseID:	FBgn0264693	Length:	1241	Species:	Drosophila melanogaster
Sequence 2:	NP_060537.3	Gene:	MAP7D1 / 55700	HGNCID:	25514	Length:	841	Species:	Homo sapiens

Alignment Length:	1090	Identity:	250/1090 - (22%)
Similarity:	377/1090 - (34%)	Gaps:	432/1090 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SLGGQHGNISTNPEVENTAKRPESREGS--AERKAHAFAPAKISGCSAGATLHWFAQVGGQISAS 65
            |..||.|.....|:.|:.:...:||..:  |.....|..|.:.|..|..|.         ..|.|
Human    70 SPSGQVGPRPAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTAV---------PASDS 125

  Fly    66 EDDSQASKDREEKLKYARDRQNEERHRKIEELRA----QAEAAQRYREQKEEERRRRIEEIRTRD 126
            ....|..|...|:.|.|::|: |||.:.:...:|    :.|.|:..||::.:|||||:||.|.:.
Human   126 PPTKQEVKKAGERHKLAKERR-EERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKA 189

  Fly   127 TEKRHQVEERKKAIFEAEKERREYILKKNQERESRIEVKKRDRNSIGFAFGSSTPRLLDVPADYG 191
            .::|..:|||::...|..|||.|..:::: .:::..|:::: |.|...|...|:|
Human   190 EQRRAALEERQRQKLEKNKERYEAAIQRS-VKKTWAEIRQQ-RWSWAGALHHSSP---------- 242

  Fly   192 LVSPSAFWGQRRSTSISNVAGASLTRRSSERELADSGAKKRASSSTDRQDDHRRKSSSMYEVFNW 256
                    |.:.|.|..:|:..:|.:.      .||...||.|.|          |::::
Human   243 --------GHKTSGSRCSVSAVNLPKH------VDSIINKRLSKS----------SATLW----- 278

  Fly   257 GYSNDEPPKRFSLSIAGSEINIDGPANPHPPPTSKQTANAHRPTNLTTTTATSTTTAGHNNFNNN 321
                :.|.:..||.::..|.:|
Human   279 ----NSPSRNRSLQLSAWESSI------------------------------------------- 296

  Fly   322 NSYRKEDSVDSSPMVFRSVYRRKTDLMPTIPSPRDGHYGSRGSLSSTPARTP--GRAYSMNRLDQ 384
                 .|.:.:..:.|.:..|....|      ||:|....||   ..|.|.|  |||
Human   297 -----VDRLMTPTLSFLARSRSAVTL------PRNGRDQGRG---CDPGRGPTWGRA-------- 339

  Fly   385 LAQPIRRNGEHMRAILERERRERELEMLDETASLGGGGGRRGAGSSARARRAGSAGSGSSSAAGI 449
                                          .|||..|........||.......:.|.|......
Human   340 ------------------------------GASLARGPQPDRTHPSAAVPVCPRSASASPLTPCS 374

  Fly   450 MSRSMTHLAGGGGQRERGKYSLGGG-ISTSFRPLASGA--GGQRDSTSKSMTQISSWSVYGSTAP 511
            ::||:...|..|.:.||.|.:.||. .....||.||..  ..::|...::..:.|:.:...|...
Human   375 VTRSVHRCAPAGERGERRKPNAGGSPAPVRRRPEASPVQKKEKKDKERENEKEKSALARERSLKK 439

  Fly   512 QQPPPNHLHHLRQSTLGLQTAATKKYLQSSFASASSFNSASFRANATGRGRQQQYAISTNPHRFL 576
            :|..|               |:.:..|.:|.||
Human   440 RQSLP---------------ASPRARLSASTAS-------------------------------- 457

  Fly   577 DLDPNSLLLMNSASLLVNAGSRSGNATPGGHFNNSRPGSAMSTSTNMSTSGLVPRRPATAPRKPR 641
            :|.|.|                           .:||.|.       |||...|..|..:|
Human   458 ELSPKS---------------------------KARPSSP-------STSWHRPASPCPSP---- 484

  Fly   642 PASIAGTGMSLEEINKLKRDQKPP-VKTTAASPSAQTTPKRTANLMSTSLIVTSSSSRLSSAEKK 705
                 |.|.:|        ..||| .:.|.|||..:...|..|                    |:
Human   485 -----GPGHTL--------PPKPPSPRGTTASPKGRVRRKEEA--------------------KE 516

  Fly   706 TPSKREPPVPKAASASKALPSRTASSERISRLTKEPKTKDTSAMTRSMIVTSSSTSTITKPAPAP 770
            :||...|       ..|:...|.||:|           |:::|.              ..|||:|
Human   517 SPSAAGP-------EDKSQSKRRASNE-----------KESAAP--------------ASPAPSP 549

  Fly   771 VAPTSAPVPEQNGVAKEVEKTTADEPVPEAEVPTEAPVVVPSVSKAEKEALNTEKTEEGARQEEE 835
             ||:..|.|.|    ||         .|.||.||:|
Human   550 -APSPTPAPPQ----KE---------QPPAETPTDA----------------------------- 571

  Fly   836 QILAVESVPEALVTSINVEEKSDEGNEKEVPKPQEQAAPKKPSRSKENSEVRELTPPEGADLMTA 900
                      |::||                 |...|.|..||:           |..|.
Human   572 ----------AVLTS-----------------PPAPAPPVTPSK-----------PMAGT----- 593

  Fly   901 SMMAKKITTEEEAKAALAERRRLAREEAERQAELERQRLEAERLAEIKAQEEEAERQRLFEEEST 965
                   |..|||...|||:||.|||:.||: |.|| ||:|||            .:|:.||:..
Human   594 -------TDREEATRLLAEKRRQAREQRERE-EQER-RLQAER------------DKRMREEQLA 637

  Fly   966 RLAEEQRRGEEERLRKAIEEAQQREEEEKRRR---EEEEKQRV--EREEAEKKAKEEAEKQRVEV 1025
            |  |.:.|.|.|      .||::|||:|.|.:   |:||::|:  ::||||.:::||||:||:|.
Human   638 R--EAEARAERE------AEARRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLER 694

  Fly  1026 AERLKREEKEREERRKRVEAIMLRTRKGGAATTPSKDANDKAAPAATAPE 1075
            .:..:::|:||:|||||:|.||.||||...:.|..|..:.:|....::||
Human   695 EKHFQQQEQERQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPE 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ens	NP_001097498.1	MAP7	920..1060	CDD:283355	61/144 (42%)
MAP7D1	NP_060537.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..151		25/90 (28%)
		NAM-associated	83..209	CDD:291001	38/135 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	184..208		7/23 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	316..813		177/741 (24%)
		MAP7	588..728	CDD:283355	69/184 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143734
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15073
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.990