DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ens and Map7d3

DIOPT Version :9

Sequence 1:	NP_001097498.1	Gene:	ens / 38491	FlyBaseID:	FBgn0264693	Length:	1241	Species:	Drosophila melanogaster
Sequence 2:	XP_006528151.1	Gene:	Map7d3 / 320923	MGIID:	2445051	Length:	935	Species:	Mus musculus

Alignment Length:	1061	Identity:	206/1061 - (19%)
Similarity:	357/1061 - (33%)	Gaps:	356/1061 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   263 PPKRFSLSIAGSEINIDGPANPHPPPT----SKQTANAHRPTNLTTTTATSTTTAGHNNFNNNNS 323
            |.||..|.:|..|          |||.    |.:.|:   ||...|:::||
Mouse    31 PKKRRRLRLAAQE----------PPPVVLNYSLKMAD---PTFAATSSSTS-------------- 68

  Fly   324 YRKEDSVDSSPMVFRSVYRRKTDLMPTIPSPR------DGHYGSRGSLSSTPARTPGRAYSMNRL 382
                         ||.::.|...:...:...|      :...|:....||||   .|.....:..
Mouse    69 -------------FRGLHERLVAMTQELAEERRHKRGINSSAGANKRSSSTP---DGSVLKNDVK 117

  Fly   383 DQLAQPIRRNGEHM------RAILERERR-----ERELE----MLDETASLGGGGGRRGAGSSAR 432
            .|||:..|...:..      :.:||:|::     |::||    .|.|...   ...||.|  ||.
Mouse   118 QQLAKERREQQKRQQEANKEKQLLEKEQKAKLQYEKQLEEKHRKLKEQKE---KDQRRQA--SAE 177

  Fly   433 ARRAGSAGSGSSSAAGIMSRSMTHLAGGGGQRERGKYSLGGGISTSFRPLASGAGGQRDSTSKSM 497
            .:|.......:.....::||::.. .....||:: ::|..||:..     |..:|...:..|.|:
Mouse   178 EKRKQKQAEDTEKFKAVVSRTLER-CNRIDQRQK-RWSWEGGVMN-----ADKSGKLENKRSSSL 235

  Fly   498 TQISSWSVYGSTAPQQPPPNHLHHLRQSTLGLQTAATKKYLQSSFASASSFNSASFRANATGRGR 562
            ::..:         :..|...:.|: .:|.|:     .||: ..:.:|..|:|...:::|
Mouse   236 SRKDN---------RLHPRGDMQHV-DNTPGM-----TKYV-FRYVTAPVFSSDEIKSSA----- 279

  Fly   563 QQQYAISTNPHRFLDLDPNSLLLMNSASLLVNAGSRSGNATPGGHFNNSRPGSAMSTSTNMSTSG 627
                         :...|::...:  |:.|....::..:|:..||..          ..:|....
Mouse   280 -------------MFCKPSAKTPV--AAKLEKITTKKLDASLRGHVE----------GLSMMNIE 319

  Fly   628 LVPRRPATAPRKPR--PASIAGTGM---SLEEINKLKRD--QKPPVKTTAASPSAQTTPKRTANL 685
            :.|:.....|..|:  .:|.|...:   ::::|:|:|.|  ||..:|.......|: .||.....
Mouse   320 IPPKITIEVPSPPKLEESSEADAEVRLQTMDDISKVKEDASQKVDIKVPTDENIAR-HPKPNVEE 383

  Fly   686 MSTSLIVTSSSSRLSSAEKKTPSKREPPVPKAASASKALPSRTASSERISRLTKEPKTKDTSAMT 750
            :|...:.||||..|||.           |...:|.|.:..|.:..|..||
Mouse   384 LSPVSVDTSSSVELSSI-----------VSVNSSPSLSTGSFSFGSVEIS--------------- 422

  Fly   751 RSMIVTSSSTSTITKPAPAPVAPTSAPVPEQNGVAKEVEKTTADEPVPEAEVPTEAPVVVPSVSK 815
                               ||....|.:......:.|:...:.:..| .:|:.||||:
Mouse   423 -------------------PVVSIDASLETNIDTSPELSMDSGNTKV-ASEIKTEAPL------- 460

  Fly   816 AEKEALNTEKTEEGARQEEEQILAVESVPEALVTSINVEEKSDEGN----EKEVPK--------P 868
                         .||.|.....:||..|||.|.......:.|:.|    .|:.|.        |
Mouse   461 -------------QARGESRLEASVEGQPEANVEGSPKNPEIDKRNINLTTKKQPLCHIPCYRWP 512

  Fly   869 QEQA---APKKPSRSKENSEVRELTP-PEGADLMTASMMAKKIT--------------------- 908
            ...|   .|..|.::.:..::|..:| |..:.|.|.:.::.|||
Mouse   513 SSSALGCRPPSPLKALQTRKIRPPSPIPVSSKLSTKTSLSYKITPVQNVLYVPNSLGVIATKKET 577

  Fly   909 ----------------TEEEAKAALAERRRLARE----EAER-QAELERQRLE------AERLAE 946
                            :.|..|.|..:.|..|.|    |.|| |.|..:||:.      ||:|.:
Mouse   578 IQKYPIKKEFGNRSMPSAEAIKKAFIQIRHAAYEQSKNEKERLQKEETKQRIARKPEIMAEKLDK 642

  Fly   947 IKA------QEEEAERQ--RLFEEESTRLAEEQRRGEEERLRKAIEEAQQREEEEKRRREEEE-- 1001
            :.|      |:|:.::.  :.|.|.......|.::|:...::       .|:..|:|::|:|.
Mouse   643 VPAEGSLPCQDEQQDKNPTKTFLESPEVQKAELQKGDSAMMK-------SRDSAEQRKKEQENIL 700

  Fly  1002 ---KQRVEREEA-------EKKAKEEAEKQ-RVEV--------AERLKREEKEREERRKRVEAIM 1047
               ::|:||.:|       |.:|.:|.|.: .:|:        :.:||:..|..:.:.:::..:.
Mouse   701 QHWQERLERRKASEISFSSEDEADDEGESEDSLEIFPSGGKMLSMKLKKFHKYAKTKPQKLVFLQ 765

  Fly  1048 LRT-----------------------------RKGG------AATTPSKDANDKAAPAATAPENN 1077
            ..|                             .||.      ..|.|.:....|....|..|..:
Mouse   766 SGTDEVDTNKNVYFNGDMKAVKQKDPKYSMIQGKGSKLSAKKPPTRPIRSRKTKEGSTAIRPTQS 830

  Fly  1078 SSSNSSVTGSSNNSAEGSPSAADSTPAP----TATETVQEAP--------NSQAMYEQSVLDKEN 1130
            :|||.       |.........|....|    |.|::.:|:|        ..||..:.....|..
Mouse   831 ASSNP-------NHKWVCDKVIDFNQTPFLKTTLTKSNKESPADSKIACQGPQAHLDHRKRTKSV 888

  Fly  1131 S--LINSFSTMIIDENAKNLQ 1149
            |  |.|..|.:.|...|.||:
Mouse   889 SVPLTNVLSHLHITGRASNLE 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ens	NP_001097498.1	MAP7	920..1060	CDD:283355	41/214 (19%)
Map7d3	XP_006528151.1	Edc3_linker	44..114	CDD:374658	20/102 (20%)
		tolA	114..>193	CDD:236545	18/83 (22%)
		MAP7	<614..711	CDD:368554	25/103 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833963
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15073
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.990