DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Chd64 and IQGAP1

DIOPT Version :9

Sequence 1:	NP_647860.1	Gene:	Chd64 / 38490	FlyBaseID:	FBgn0035499	Length:	188	Species:	Drosophila melanogaster
Sequence 2:	NP_003861.1	Gene:	IQGAP1 / 8826	HGNCID:	6110	Length:	1657	Species:	Homo sapiens

Alignment Length:	158	Identity:	37/158 - (23%)
Similarity:	78/158 - (49%)	Gaps:	20/158 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 EAQRKINSKYSEELA--QESLEWIKAVTEEPINTSGDTDNFFEVLKDGVILCKLANALQPG--SI 74
            :.:|:.|..| |.|.  :|:..|::|...|.:..:.:.:   |.|::||.|.||.|...|.  |:
Human    32 DERRRQNVAY-EYLCHLEEAKRWMEACLGEDLPPTTELE---EGLRNGVYLAKLGNFFSPKVVSL 92

  Fly    75 KKINESK--------MAFKCMENISAFLACAKNFGVPTQETFQSVDLWERQNLNSVVICLQSLGR 131
            |||.:.:        :.|:..:|:..:|......|:|.....::.|:::|:|:...:.|:.:|
Human    93 KKIYDREQTRYKATGLHFRHTDNVIQWLNAMDEIGLPKIFYPETTDIYDRKNMPRCIYCIHAL-- 155

  Fly   132 KASNFNKPSIGPKEADKNVR-NFSDEQL 158
             :....|..:.|:..|...: :|::|::
Human   156 -SLYLFKLGLAPQIQDLYGKVDFTEEEI 182

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd64	NP_647860.1	CH_SF	22..131	CDD:412120	30/120 (25%)
Chd64	NP_647860.1	Calponin	165..187	CDD:395325
IQGAP1	NP_003861.1	CH	45..159	CDD:237981	27/119 (23%)
		WW	685..710	CDD:238122
		IQ	774..796	CDD:197470
		C1	956..1274
		RasGAP	992..1344	CDD:214617
		RasGAP_IQGAP1	1003..1382	CDD:213335
		C2	1276..1657
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1410..1448
		RasGAP_C	1452..1580	CDD:281787
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2278
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940