DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Chd64 and IQGAP3

DIOPT Version :9

Sequence 1:	NP_647860.1	Gene:	Chd64 / 38490	FlyBaseID:	FBgn0035499	Length:	188	Species:	Drosophila melanogaster
Sequence 2:	XP_024309041.1	Gene:	IQGAP3 / 128239	HGNCID:	20669	Length:	1643	Species:	Homo sapiens

Alignment Length:	151	Identity:	38/151 - (25%)
Similarity:	77/151 - (50%)	Gaps:	30/151 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RAAKSGFAA--------------EAQRKINSKYSEELA--QESLEWIKAVTEEPINTSGDTDNFF 53
            |||..|:||              :.||:.|..| :.|.  :|:..|::|..:|.:.:..:.:
Human     4 RAAGPGWAACECGEDERLTAEEMDEQRRQNVAY-QYLCRLEEAKRWMEACLKEELPSPVELE--- 64

  Fly    54 EVLKDGVILCKLANALQPG--SIKKINE--------SKMAFKCMENISAFLACAKNFGVPTQETF 108
            |.|::||:|.||.:...|.  .:|||.:        :.:.|:..:||:.:|:...:.|:|:....
Human    65 ESLRNGVLLAKLGHCFAPSVVPLKKIYDVEQLRYQATGLHFRHTDNINFWLSAIAHIGLPSTFFP 129

  Fly   109 QSVDLWERQNLNSVVICLQSL 129
            ::.|:::::|:..||.|:.:|
Human   130 ETTDIYDKKNMPRVVYCIHAL 150

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd64	NP_647860.1	CH_SF	22..131	CDD:412120	29/120 (24%)
Chd64	NP_647860.1	Calponin	165..187	CDD:395325
IQGAP3	XP_024309041.1	RasGAP_C	16..>209	CDD:332048	32/139 (23%)
		Myosin_head	<746..>969	CDD:332202
		RasGAP_C	<873..1643	CDD:332048
		RasGAP_IQGAP3	999..1348	CDD:213346
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2278
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940