DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Chd64 and CNN2

DIOPT Version :9

Sequence 1:	NP_647860.1	Gene:	Chd64 / 38490	FlyBaseID:	FBgn0035499	Length:	188	Species:	Drosophila melanogaster
Sequence 2:	NP_001290430.1	Gene:	CNN2 / 1265	HGNCID:	2156	Length:	330	Species:	Homo sapiens

Alignment Length:	210	Identity:	70/210 - (33%)
Similarity:	108/210 - (51%)	Gaps:	30/210 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NRAAKSGFAAEAQRKINSKYSEELAQESLEWIKAVTEEPINTSGDTDNFFEVLKDGVILCKLANA 68
            |:....|.:||.:.::.|||..:...|...||:.:|...|.     .:|.:.||||.|||.|.|.
Human     7 NKGPSYGLSAEVKNRLLSKYDPQKEAELRTWIEGLTGLSIG-----PDFQKGLKDGTILCTLMNK 66

  Fly    69 LQPGSIKKINESKMAFKCMENISAFLACAKNFGVPTQETFQSVDLWERQNLNSVVICLQSLGRKA 133
            |||||:.|||.|...:..:||:|.|:....::|:...:.|::.||:|..|:..|.:.|.:|..|.
Human    67 LQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMNPVDLFEANDLFESGNMTQVQVSLLALAGKG 131

  Fly   134 SN---------FNKP---------------SIGPKEADKNVRNFSDEQLRAGANVISLQYGSNKG 174
            .:         :::|               .||.|.::|..|||.|..::||..||.||.|:||.
Human   132 LDLGSLAALCWYSRPLSLTQAKTKGLQSGVDIGVKYSEKQERNFDDATMKAGQCVIGLQMGTNKC 196

  Fly   175 ATQSGIN-FGNTRHM 188
            |:|||:. :|..||:
Human   197 ASQSGMTAYGTRRHL 211

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd64	NP_647860.1	CH_SF	22..131	CDD:412120	39/108 (36%)
Chd64	NP_647860.1	Calponin	165..187	CDD:395325	11/22 (50%)
CNN2	NP_001290430.1	Calponin	19..211	CDD:332521	65/196 (33%)
CNN2	NP_001290430.1	Calponin	227..250	CDD:306832
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144831
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5199
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D488325at33208
OrthoFinder	1	1.000	-	-		FOG0000270
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2278
SonicParanoid	1	1.000	-	-		X194
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.780