DRSC/TRiP Functional Genomics Resources

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Protein Alignment KRT2 and LamC

DIOPT Version :10

Sequence 1:NP_000414.2 Gene:KRT2 / 3849 HGNCID:6439 Length:639 Species:Homo sapiens
Sequence 2:NP_001260974.1 Gene:LamC / 36615 FlyBaseID:FBgn0010397 Length:640 Species:Drosophila melanogaster


Alignment Length:447 Identity:117/447 - (26%)
Similarity:202/447 - (45%) Gaps:109/447 - (24%)


- Green bases have known domain annotations that are detailed below.


Human   175 KAQEREQIKTLNNKFASFIDKVRFLEQQNQVLQTKWELLQQMNVGTRPINLEPIFQGYI------ 233
            :.||:|:::.||::.|.:||::|.||.:|..|..:..|.|. .|.....||:.:::..:      
  Fly    43 RQQEKEELQHLNDRLACYIDRMRNLENENSRLTQELNLAQD-TVNRETSNLKAVYEKELAAARKL 106

Human   234 ----------------------DSLKRYLDGLTAERT----------SQNSELNNM--QDLVEDY 264
                                  |.||..||..|.|.|          ::.:|:|..  |.|.:  
  Fly   107 LDETAKEKAKLEIDIKRLWEENDDLKPRLDKKTKEATVAENNARLYENRYNEVNGKYNQSLAD-- 169

Human   265 KKKYEDEINKRTAAENDFV-----TLKKDVDNAYMIKVELQSKVDLLNQEIEFLKVLYDAEISQI 324
            :||:||:. |..|.||:.:     .|:|.::...:.:|:|:::...|.:|:.|.        .|:
  Fly   170 RKKFEDQA-KELALENERLRRQLDDLRKQLEAETLARVDLENQNQSLREELAFK--------DQV 225

Human   325 H-QSVTDTNVILSMDNSRNLDLDSIIAEVKAQYEEIAQRS---------------KEEAEALYHS 373
            | |.:|:|.      :.|.:::..|...:..|||...|:|               :||.|.||.:
  Fly   226 HTQELTETR------SRRQIEISEIDGRLSRQYEAKLQQSLQELRDQYEGQMRINREEIELLYDN 284

Human   374 KYEELQVTVGR--HGDSL--KEIKI---EISELNRVIQRLQGEIAHVKKQCKNVQDAIADAEQRG 431
            :.:.|:....|  .|.:|  :|:::   :|..||..:|.|:...|.:..:.:.:::.:....||.
  Fly   285 EIQNLKAAANRAAQGSALATEEVRLMRTKIDGLNAKLQNLEDTNAGLNARIRELENLLDTERQRH 349

Human   432 EHALKDARNKLNDLEEALQQAKEDLARLLRDYQELMNVKLALDVEIATYRKLLEGEECRMSGDLS 496
            ...:.       .||..||:.::::|..|::||.||::|::||:|||.|.|||.|||.|::.:..
  Fly   350 NQYIA-------SLEAELQRMRDEMAHQLQEYQGLMDIKVSLDLEIAAYDKLLCGEERRLNIESP 407

Human   497 SNVTVSVTSSTISSNVASKAAFGGSGGRGSSSGGGYSSGSSSYGSGGRQSGSRGGSG 553
            ...|   |.|.||||             ||......||.|......||:|.:.|.||
  Fly   408 GRPT---TDSGISSN-------------GSHLTASASSRSGRVTPSGRRSATPGISG 448

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KRT2NP_000414.2 Head 1..177 0/1 (0%)
Keratin_2_head <150..174 CDD:465068
Filament 177..490 CDD:459643 98/380 (26%)
Coil 1A 178..213 12/34 (35%)
Linker 1 214..232 4/17 (24%)
Coil 1B 233..324 27/135 (20%)
Linker 12 325..348 5/23 (22%)
Coil 2 349..487 43/159 (27%)
Tail 488..639 20/66 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 514..559 11/40 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 574..639
LamCNP_001260974.1 Filament 45..401 CDD:459643 98/380 (26%)
PRK13922 154..>221 CDD:473155 18/69 (26%)
LTD 474..574 CDD:460003
Blue background indicates that the domain is not in the aligned region.

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