DRSC/TRiP Functional Genomics Resources

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Protein Alignment KRT2 and Lam

DIOPT Version :10

Sequence 1:NP_000414.2 Gene:KRT2 / 3849 HGNCID:6439 Length:639 Species:Homo sapiens
Sequence 2:NP_476616.1 Gene:Lam / 33782 FlyBaseID:FBgn0002525 Length:622 Species:Drosophila melanogaster


Alignment Length:429 Identity:104/429 - (24%)
Similarity:200/429 - (46%) Gaps:84/429 - (19%)


- Green bases have known domain annotations that are detailed below.


Human   138 PGGFGPGGYPGGIHEVSVNQSLLQPLNVKVDPEIQNVKAQEREQIKTLNNKFASFIDKVRFLEQQ 202
            |...||...|...|    :|:...||:     ..::.:..|:.:::.||::.|::||:||.||.:
  Fly    23 PPSAGPQPPPPSTH----SQTASSPLS-----PTRHSRVAEKVELQNLNDRLATYIDRVRNLETE 78

Human   203 NQVLQTKWELLQQMNVGTRPINLEPIFQGYI----------------------------DSLKRY 239
            |..|..:.:..:. .|.....|::.||:..:                            :.||..
  Fly    79 NSRLTIEVQTTRD-TVTRETTNIKNIFEAELLETRRLLDDTARDRARAEIDIKRLWEENEELKNK 142

Human   240 LDGLTAERT----------SQNSELNNMQDLVEDYKKKYEDEINKR----TAAENDFVTLKKDVD 290
            ||..|.|.|          |:.:||||..:.....:||..:::|:.    ......|...:|:::
  Fly   143 LDKKTKECTTAEGNVRMYESRANELNNKYNQANADRKKLNEDLNEALKELERLRKQFEETRKNLE 207

Human   291 NAYMIKVELQSKVDLLNQEIEFLKVLYDAEIS------QIHQSVTDTNVILSMDNSRNLDLDSII 349
            ...:.:|:|::.:..|.:|:.|...::..||:      |...|..|..    :.:..:..|...:
  Fly   208 QETLSRVDLENTIQSLREELSFKDQIHSQEINESRRIKQTEYSEIDGR----LSSEYDAKLKQSL 268

Human   350 AEVKAQYEEIAQRSKEEAEALYHSKYEELQVTVGRHGDS-------LKEIKIEISELNRVIQRLQ 407
            .|::|||||..|.:::|.::||..|.:.||....|..:|       |:..::.|..||..|..|:
  Fly   269 QELRAQYEEQMQINRDEIQSLYEDKIQRLQEAAARTSNSTHKSIEELRSTRVRIDALNANINELE 333

Human   408 GEIAHVKKQCKNVQDAI-ADAEQRGEHALKDARNKLNDLEEALQQAKEDLARLLRDYQELMNVKL 471
            ...|.:..:.::::..: .|.|:.|:        :::.||:.|.:.:|::.:.|::||:||::|:
  Fly   334 QANADLNARIRDLERQLDNDRERHGQ--------EIDLLEKELIRLREEMTQQLKEYQDLMDIKV 390

Human   472 ALDVEIATYRKLLEGEECRMSGDLSSNVTVSVTSSTISS 510
            :||:|||.|.|||.|||.|:      |:|.:..::|:.|
  Fly   391 SLDLEIAAYDKLLVGEEARL------NITPATNTATVQS 423

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KRT2NP_000414.2 Head 1..177 8/38 (21%)
Keratin_2_head <150..174 CDD:465068 4/23 (17%)
Filament 177..490 CDD:459643 91/368 (25%)
Coil 1A 178..213 12/34 (35%)
Linker 1 214..232 4/17 (24%)
Coil 1B 233..324 24/138 (17%)
Linker 12 325..348 3/22 (14%)
Coil 2 349..487 44/145 (30%)
Tail 488..639 6/23 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 514..559
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 574..639
LamNP_476616.1 Filament 54..409 CDD:459643 91/367 (25%)
LTD 467..572 CDD:460003
Blue background indicates that the domain is not in the aligned region.

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