DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ack and TNK1

DIOPT Version :9

Sequence 1:	NP_647859.1	Gene:	Ack / 38489	FlyBaseID:	FBgn0028484	Length:	1073	Species:	Drosophila melanogaster
Sequence 2:	NP_001238831.1	Gene:	TNK1 / 8711	HGNCID:	11940	Length:	666	Species:	Homo sapiens

Alignment Length:	805	Identity:	259/805 - (32%)
Similarity:	360/805 - (44%)	Gaps:	199/805 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 WLEDLLREVQLEQFLDRIRDDLQVTRLAHFDYVLPDDLERCGLGKPAIRRLMEAVRKKKAHQWRK 81
            ||..|||::||.||...|.::|.|||..|||:|.|:||:..|:|:||.|||.||:::.::....|
Human     9 WLLKLLRDIQLAQFYWPILEELNVTRPEHFDFVKPEDLDGIGMGRPAQRRLSEALKRLRSGPKSK 73

  Fly    82 NILSKLIGG----GKQPSSKKQSSAARESSQGNGTQLTCLIHEKDITMGLKLGDGSFGVVRRGEW 142
            |.:.|::||    .|:|:....|.......:|.   |.|||.|..:..|..||.|.||||.||.|
Human    74 NWVYKILGGFAPEHKEPTLPSDSPRHLPEPEGG---LKCLIPEGAVCRGELLGSGCFGVVHRGLW 135

  Fly   143 SASPAGKVIPVAVKVLKSDNLTQPGI-IDDFFREVQAMHALDHANLVRLYGVVLSQPMMMITELA 206
            :. |:||.:|||||.|:.......|. :.||.|||..|..|:|.:::||:|:||.||:.|:.|||
Human   136 TL-PSGKSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHVLRLHGLVLGQPLQMVMELA 199

  Fly   207 ERGSLLDTLRKQCRHTSLT-----------IIWNWSVQIVTGMAYLEQKRFLHRDLACRNVLLAA 260
            ..|||         |..||           ::..:..|:...||||..:..:|||||.||:|||:
Human   200 PLGSL---------HARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLAS 255

  Fly   261 GNKIKIGDFGLMRALPQEDDCYVMSEHKKVPFPWCAPESLRFRQFSHASDTWMFGVTLWEMFSFG 325
            ...||:.||||:|.|......|||...:.:|:.||||||||...||.|||.||||||||||||.|
Human   256 PRTIKVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRHGAFSSASDVWMFGVTLWEMFSGG 320

  Fly   326 EDPWVGLNGSQILRKIDREGERLHQPDACPPDVYAMMLQCWDKTPAERPTFAALKEYLASMSPPV 390
            |:||.|:....||:::: :..||.:|..|...:|::.|:||...||:||:|:.|:..|....|..
Human   321 EEPWAGVPPYLILQRLE-DRARLPRPPLCSRALYSLALRCWAPHPADRPSFSHLEGLLQEAGPSE 384

  Fly   391 MRASRSHHESKGLQIEPGDTIAIIDGRH-----ELKLIKGQNQRTFDIGIFPRNLLEQRKVGAAG 450
            ....|...|...|::|.||.|.:|:|..     :..:.||||.|||.:|.||.:.:   .:..||
Human   385 ACCVRDVTEPGALRMETGDPITVIEGSSSFHSPDSTIWKGQNGRTFKVGSFPASAV---TLADAG 446

  Fly   451 DVVMRSSVGNGSSSSPFGFCWGGAAAMANGD------DRQRKCASMTNQPHAKERKSTSSKQFAY 509
            .:.....|..|:.              |.||      |..||.|::.:.|.|:.
Human   447 GLPATRPVHRGTP--------------ARGDQHPGSIDGDRKKANLWDAPPARG----------- 486

  Fly   510 NKLVNDSATGLQRRNAVKHKGVVVGPQRPPPPQFQQEGILIDISPDMRPIAEAGTGGAKGAGDSS 574
                       ||||.               |..:.:||                        |.
Human   487 -----------QRRNM---------------PLERMKGI------------------------SR 501

  Fly   575 SLQADSSFCILDAPIDVPTYAGSSGSGDLNVSPTYYNEQPQFDFDPAKMTASPGRLQPPPYQMPP 639
            ||::..|.    .|  .||..|||              .|:.....|.....||.   ||  .||
Human   502 SLESVLSL----GP--RPTGGGSS--------------PPEIRQARAVPQGPPGL---PP--RPP 541

  Fly   640 TYSNTMEFVQKRDLHQQQLATPVRERDPFDTTNVETTVALYSNFNQSLEAASPP--APIYNSPSV 702
            ..|::           .|.:.|.|||.|:                   ....||  .|: ..|..
Human   542 LSSSS-----------PQPSQPSRERLPW-------------------PKRKPPHNHPM-GMPGA 575

  Fly   703 RK--SLFGGSKSNKENIPALESAAMQLNLSNLTLERHDATCIQPVEPVPAPPGDGVLLDKSFIAE 765
            ||  :|.||..|:    |.|:...|::.||     .|..|..:....:.|..||.|    |.|..
Human   576 RKAAALSGGLLSD----PELQRKIMEVELS-----VHGVTHQECQTALGATGGDVV----SAIRN 627

  Fly   766 LEKD--MYSNGQNRAQ-----EEYQ 783
            |:.|  .:.:.::||.     |.||
Human   628 LKVDQLFHLSSRSRADCWRILEHYQ 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack	NP_647859.1	SAM_TNK-like	14..75	CDD:188938	30/57 (53%)
		PTKc_Ack_like	128..385	CDD:270636	119/268 (44%)
		UBA_TNK1	1031..1070	CDD:270513
TNK1	NP_001238831.1	SAM_TNK-like	6..67	CDD:188938	30/57 (53%)
		STYKc	119..377	CDD:214568	119/268 (44%)
		PKc_like	120..379	CDD:304357	119/269 (44%)
		SH3	385..441	CDD:214620	19/58 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	446..493		16/97 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	506..579		28/128 (22%)
		UBA_like_SF	594..637	CDD:304366	13/51 (25%)
		UBA_TNK1	624..663	CDD:270513	8/29 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0199
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4151
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1008736at2759
OrthoFinder	1	1.000	-	-		FOG0002936
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.830