DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ack and Tnk1

DIOPT Version :10

Sequence 1:NP_647859.1 Gene:Ack / 38489 FlyBaseID:FBgn0028484 Length:1073 Species:Drosophila melanogaster
Sequence 2:NP_114086.3 Gene:Tnk1 / 83813 MGIID:1930958 Length:666 Species:Mus musculus


Alignment Length:646 Identity:228/646 - (35%)
Similarity:317/646 - (49%) Gaps:87/646 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 SETAWLEDLLREVQLEQFLDRIRDDLQVTRLAHFDYVLPDDLERCGLGKPAIRRLMEAVRKKKAH 77
            :.:.||..|||:|||.||...|.::|.|||..|||:|.|:||:..|:|:||.|||.||:::.::.
Mouse     5 ASSLWLLRLLRDVQLAQFYRPILEELNVTRPEHFDFVRPEDLDNIGMGRPAQRRLNEALKRYRSG 69

  Fly    78 QWRKNILSKLIGG----GKQPSSKKQSSAARESSQGNGTQLTCLIHEKDITMGLKLGDGSFGVVR 138
            ...||.:.|::||    .|:...:..|.......:|.   |.|||.|..:..|..||.|.||||.
Mouse    70 VKSKNWVYKILGGFAPEQKEIPPRSDSPLCFHEPEGG---LKCLIPEGAVRRGELLGSGCFGVVH 131

  Fly   139 RGEWSASPAGKVIPVAVKVLKSDNLTQPGI-IDDFFREVQAMHALDHANLVRLYGVVLSQPMMMI 202
            ||.|:. |:|:.||||||.|:.......|. :.||.|||..|..|:|.:::||:|:||.||:.|:
Mouse   132 RGLWTL-PSGQSIPVAVKSLRVGPEGPMGTELGDFLREVSVMMKLEHPHVLRLHGLVLGQPLQMV 195

  Fly   203 TELAERGSLLDTLRKQCRHTSLT-----------IIWNWSVQIVTGMAYLEQKRFLHRDLACRNV 256
            .|||..|||         |..||           ::..:..|:...||||.....:|||||.||:
Mouse   196 MELAPLGSL---------HARLTAPAPTPPLPVALLCLFLRQLAGAMAYLGSCGLVHRDLATRNL 251

  Fly   257 LLAAGNKIKIGDFGLMRALPQEDDCYVMSEHKKVPFPWCAPESLRFRQFSHASDTWMFGVTLWEM 321
            |||:...||:.||||:|.|......|||...:.:|:.||||||||...||.|||.||||||||||
Mouse   252 LLASPRMIKVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRQGAFSSASDVWMFGVTLWEM 316

  Fly   322 FSFGEDPWVGLNGSQILRKIDREGERLHQPDACPPDVYAMMLQCWDKTPAERPTFAALKEYLASM 386
            ||.||:||.|:....||::::::..||.:|..|...:|::.|:||...||:||:|:.|:..|...
Mouse   317 FSGGEEPWAGVPPYLILQRLEKDRARLPKPPLCSRALYSLALRCWAPHPADRPSFSNLEGLLQEA 381

  Fly   387 SPPVMRASRSHHESKGLQIEPGDTIAIIDGRHELKLIKGQNQRTFDIGIFPRNLLEQRKVGAAGD 451
            .....|..|...|...|::||||.|.||:|..:....||||.||..:|.||.:.:....:|  |.
Mouse   382 WLSEGRCVREVTEPGALRMEPGDPITIIEGSLDTATWKGQNGRTLKVGNFPASAVTLADLG--GS 444

  Fly   452 VVM----RSSVGNGSSSSPFGFCWGGAAAMANGDDRQRKCASMTNQPHAK--------ERKSTSS 504
            .|.    |.|..:|..      |.||.       |..|:.|::.:.|.|:        :|....|
Mouse   445 PVTHPAHRGSPAHGEK------CRGGT-------DGDREKATLQDLPPARSHRTKMPLQRMRGIS 496

  Fly   505 KQFAYNKLVNDSATG-------LQRRNAVKHKGVVVGPQR-----PPPPQFQQEGILIDISPD-- 555
            |.......:....||       |:|..|:        |||     |.||.......:|..|..  
Mouse   497 KSLESVLSLGPRPTGGGSSPPELRRTRAM--------PQRLPDLPPRPPDLPPRPPIICNSSQPT 553

  Fly   556 ----MRPIAEAGTGGAKGAGDSSSLQADSSFCILDAPIDVPTYAGSSGSGDLNVSPTYYNE 612
                .||..|:......||..:|.....|.     .|:..|.:.......:|:|....|.|
Mouse   554 QPHKARPKRESSHNHRTGAPGASKATVPSG-----GPLSDPEWQRKVVEVELSVHGVTYQE 609

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AckNP_647859.1 SAM_TNK-like 14..75 CDD:188938 31/60 (52%)
PTKc_Ack_like 128..385 CDD:270636 119/268 (44%)
UBA_TNK1 1031..1070 CDD:270513
Tnk1NP_114086.3 SAM_TNK-like 16..67 CDD:188938 26/50 (52%)
Protein Kinases, catalytic domain 120..380 CDD:473864 119/269 (44%)
SH3 <395..436 CDD:473055 18/40 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 442..589 38/174 (22%)
UBA_like_SF 594..637 CDD:473871 4/16 (25%)
UBA_like_SF 624..663 CDD:473871
Blue background indicates that the domain is not in the aligned region.

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