DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ack and tnk1

DIOPT Version :9

Sequence 1:	NP_647859.1	Gene:	Ack / 38489	FlyBaseID:	FBgn0028484	Length:	1073	Species:	Drosophila melanogaster
Sequence 2:	NP_001073486.2	Gene:	tnk1 / 565029	ZFINID:	ZDB-GENE-030131-7427	Length:	733	Species:	Danio rerio

Alignment Length:	749	Identity:	285/749 - (38%)
Similarity:	386/749 - (51%)	Gaps:	112/749 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ETAWLEDLLREVQLEQFLDRIRDDLQVTRLAHFDYVLPDDLERCGLGKPAIRRLMEAVRKKKAHQ 78
            :|.||..||.:||||:|..|:||.|.|||:.|..||...|||:.|:.||..|||.|||::.|.:.
Zfish     5 DTQWLYQLLADVQLERFYLRMRDGLNVTRMEHLSYVKEADLEQIGISKPGQRRLWEAVKRYKTNM 69

  Fly    79 WRKNILSKLIGGGKQPSSKKQSSAARESSQGNGTQLTCLIHEKDITMGLKLGDGSFGVVRRGEWS 143
            ..::.:.|.. .|:.|....||:|| .|.||....|||||.::::..|.:||.|||||||:.||.
Zfish    70 RARSWMVKAT-NGRAPEGNDQSNAA-GSGQGPVRALTCLIQDRELLFGDRLGSGSFGVVRKAEWH 132

  Fly   144 ASPAGKVIPVAVKVLKSDNLTQPGIIDDFFREVQAMHALDHANLVRLYGVVLSQPMMMITELAER 208
             :|.|:|:|||||.|:|.   |..::.||.:||.:|.:|||.|::.||||||:.|:.|:||||..
Zfish   133 -TPTGRVLPVAVKTLRSG---QVDLVSDFLQEVTSMQSLDHPNIIHLYGVVLTHPLKMVTELAPL 193

  Fly   209 GSLLDTLRKQCRHTSLTIIWNWSVQIVTGMAYLEQKRFLHRDLACRNVLLAAGNKIKIGDFGLMR 273
            |||.||||.:.....|:.:|.:|.||..||.|||.:||:|||||.|||||||..::|||||||||
Zfish   194 GSLYDTLRLRHGEYPLSRLWLFSTQIAAGMEYLESRRFIHRDLAARNVLLAAREQVKIGDFGLMR 258

  Fly   274 ALPQEDDCYVMSEHKKVPFPWCAPESLRFRQFSHASDTWMFGVTLWEMFSFGEDPWVGLNGSQIL 338
            .|...|. |:|:.|:::||.||||||||...||||||.|||||||||||::.|:||:||:|.|||
Zfish   259 GLDDRDH-YIMTAHRRIPFAWCAPESLRTGSFSHASDVWMFGVTLWEMFTYCEEPWLGLSGRQIL 322

  Fly   339 RKIDREGERLHQPDACPPDVYAMMLQCWDKTPAERPTFAALKEYLASMSPPVMRASRSHHESKGL 403
            .:::||||||.:|..||.::||:|.:||.....||||||.|...::...|..:|:.:...|.:.|
Zfish   323 YRVEREGERLERPPDCPQELYAVMRKCWACNSTERPTFAQLTTMVSEAQPMEVRSVKDIAEPRRL 387

  Fly   404 QIEPGDTIAIIDGRHELKLI--KGQNQRTFDIGIFPRNLLE---QRKVGAAGDVVMRSSV----- 458
            .::..|.:.:||  |.|.:.  |||||||..:|.||..|..   ...|.|:|..::.|.|
Zfish   388 SLQANDLVTVID--HGLDMCEWKGQNQRTLSVGWFPPALTAPALTAVVPASGPTLISSPVRGSLH 450

  Fly   459 --GNGSSSSPFGFCWGGAAAMANGDDRQRKCASMTNQPHAKERKSTSSKQFAYNKL--------- 512
              |:|.:..  |..||....:   ||.:|     ...|.|||::.::.|:.|....
Zfish   451 HTGHGDTDP--GRSWGTPERI---DDNRR-----WRVPLAKEKEGSNLKKMAGMSRSLESVLGGP 505

  Fly   513 --------VNDSATGLQRRNAVKHK----------GVVVGPQRPPPPQFQQEGILIDISPDMRPI 559
                    ||.:....||||...:.          .||:.|.|||||..:      .|.|.|. :
Zfish   506 QDKGRGFGVNAAQRSDQRRNMQNNNVIQDPRRFSDAVVIPPPRPPPPNIK------SIKPQMM-M 563

  Fly   560 AEAGTGGAKGAGDSSSLQADSSFCILDAPIDVPTYAGSSGSGDLNVSPTYYNEQPQFD------- 617
            .......|..:|.|...||...|        .|...| .|:.:|..........||.|
Zfish   564 MFLDRRAANPSGWSPQTQAQPQF--------QPQQQG-LGTSNLTRMTHLAKSSPQLDDVIEKDK 619

  Fly   618 ----FDPAKMTASPGRLQPPP---------YQMPPTYSNTMEFVQKRDLH---------QQQLAT 660
                ....:.....|:.:.||         ......:..|.|.|||. ||         :|||.|
Zfish   620 EREKEQEREREREKGKERYPPLVDKEAVIAQVQAAVHGVTNEEVQKA-LHRCDWNPTKAEQQLKT 683

  Fly   661 PVRERDPFDTTNV---ETTVALYSNFNQSLEAAS 691
                 |.....|.   |....:.|.:|..|:.||
Zfish   684 -----DQLYYMNQCTREECQKVLSRYNWDLQIAS 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack	NP_647859.1	SAM_TNK-like	14..75	CDD:188938	32/60 (53%)
		PTKc_Ack_like	128..385	CDD:270636	145/256 (57%)
		UBA_TNK1	1031..1070	CDD:270513
tnk1	NP_001073486.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0199
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1008736at2759
OrthoFinder	1	1.000	-	-		FOG0002936
OrthoInspector	1	1.000	-	-		otm26481
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3854
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.880