DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ack and tnk2b

DIOPT Version :9

Sequence 1:	NP_647859.1	Gene:	Ack / 38489	FlyBaseID:	FBgn0028484	Length:	1073	Species:	Drosophila melanogaster
Sequence 2:	XP_021336227.1	Gene:	tnk2b / 559119	ZFINID:	ZDB-GENE-110411-165	Length:	1118	Species:	Danio rerio

Alignment Length:	1224	Identity:	392/1224 - (32%)
Similarity:	553/1224 - (45%)	Gaps:	298/1224 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LGSE------TAWLEDLLREVQLEQFLDRIRDDLQVTRLAHFDYVLPDDLERCGLGKPAIRRLME 69
            |||.      |.||.:||.||||:|:..||||:|.:|||:|||||..:|||:.|:|:|..|||.|
Zfish    23 LGSSMQCEEGTEWLLELLMEVQLQQYFLRIRDELNITRLSHFDYVKNEDLEKIGMGRPGQRRLWE 87

  Fly    70 AVRKKKAHQWRKNILSKLIGGGKQPS---SKKQSSAARESS------QGNGTQLTCLIHEKDITM 125
            ||:::|....||:.:||:. .||:|.   :.:.:|..|:.|      .|....|||||.|||:.:
Zfish    88 AVKRRKTMCKRKSWMSKVF-SGKRPEGDFNPQPASTFRKLSPTPPLVDGQQQALTCLISEKDLAL 151

  Fly   126 GLKLGDGSFGVVRRGEWSASPAGKVIPVAVKVLKSDNLTQPGIIDDFFREVQAMHALDHANLVRL 190
            ..||||||||||:|||| .:|.|||:.||||.||:|.|.||..:|||.|||.|||:|||.||:||
Zfish   152 FEKLGDGSFGVVKRGEW-FTPNGKVLNVAVKCLKTDVLNQPDALDDFIREVNAMHSLDHQNLIRL 215

  Fly   191 YGVVLSQPMMMITELAERGSLLDTLRKQCRHTSLTIIWNWSVQIVTGMAYLEQKRFLHRDLACRN 255
            |||||:.||.|:||||..||:||.|||...|..::.:..:::||..||.|||.|||:|||||.||
Zfish   216 YGVVLTHPMKMVTELAPLGSMLDRLRKTLGHFLISTLCQYTIQISNGMGYLESKRFIHRDLAARN 280

  Fly   256 VLLAAGNKIKIGDFGLMRALPQEDDCYVMSEHKKVPFPWCAPESLRFRQFSHASDTWMFGVTLWE 320
            :|||:..::||||||||||||:.||.|||.||:||||.|||||||:.|.||||:|||||||||||
Zfish   281 ILLASSEQVKIGDFGLMRALPKNDDHYVMQEHRKVPFAWCAPESLKTRTFSHATDTWMFGVTLWE 345

  Fly   321 MFSFGEDPWVGLNGSQILRKIDREGERLHQPDACPPDVYAMMLQCWDKTPAERPTFAALKEYLAS 385
            ||::|::||:||||||||.|||:|||||.:|:.||.|:|.:|:|||.:.|.:||||.||:|:|..
Zfish   346 MFTYGQEPWLGLNGSQILHKIDKEGERLPKPEDCPQDLYNVMMQCWAQKPDDRPTFVALREFLVE 410

  Fly   386 MSPPVMRASRSHHESKGLQIEPGDTIAIIDGRHELKLIKGQNQRTFDIGIFPRNLLEQRKVGAAG 450
            ..|..|||.:...|...|||:..|.|.||:||.|....:|||:||..:|.||||.:......:|.
Zfish   411 TMPTDMRALQDFDEPDKLQIQMDDVITIIEGRAENYWWRGQNKRTLKVGQFPRNTVTSVAGLSAH 475

  Fly   451 DV---VMRSSVGNGSSSSPFGFCWG--------------------------GAAAMANGDDRQRK 486
            |:   :..|.:..|...:....|||                          .......|..::..
Zfish   476 DISRPLKNSFIHTGHGDTNPHRCWGFPDRIDDLYLGNPMDPPDVLGLDLNSARPTQLPGRAKKEP 540

  Fly   487 CASMTNQPHAKERKSTSSKQF------------------AYNKLVND--SATGLQRRNAVKHKGV 531
            .......|...:.|...|.||                  .|:.:..|  ......||.::|.||:
Zfish   541 PPRPPQPPLLVKSKCGPSVQFKHCSCPLCSLLAPLIKEPCYDAVAEDEEQTYSALRRLSLKKKGL 605

  Fly   532 VVGP----------------QRPPPPQFQQEGILIDI---------SPDMRPIAEAGTGG-AKGA 570
            .:.|                .|.|......|..|||.         ||.  |:||..... ||.|
Zfish   606 KLKPAAWVSATRLGDRSSYGARTPGGSTPTEVSLIDFGEEYPSATSSPS--PVAEIQIPTLAKLA 668

  Fly   571 GDSSSLQADSSFCILD-APIDVPTYAGSSGSGDLNVSPTYYNEQPQFDFDPAKMTASPGRLQPPP 634
            .|:.:        ||| .|...|:          ...|...:..|..|:|        .|..||
Zfish   669 LDAEN--------ILDRTPPQSPS----------RTLPRPLHPTPVVDWD--------ARPLPP- 706

  Fly   635 YQMPPTYSNTMEFVQKRDLHQQQLATPVRERDPFDTTNVETTVALYSNFNQSLEAASPPAPI--- 696
               ||.|.:.                 .::.|.|:.:::.      |......|..||.||.
Zfish   707 ---PPAYDDV-----------------AQDEDDFEVSSIN------SAERADGEPCSPHAPCTPT 745

  Fly   697 -YNSPSVRKSLFGGSK--------SNKENIPALESAAMQ-----LNLSNLTLERH---------D 738
             .:.|.|..:||...:        .:.|....|:...|:     :|.::..||.|         |
Zfish   746 GESKPHVEDNLFLPCRLSNACTFSQSAEIFQELQQECMRHLKVPVNSTSPGLEPHRQIVLTFSED 810

  Fly   739 ATCIQPVEPVPAPPGDGVLLDKSFIAELEKDMYSNGQNRAQEEYQRNS---TQMYASKDMVYK-Q 799
            ...|.|..|:|..|                      ..||..:|.|.|   :.::.::|...: .
Zfish   811 KPQIPPRIPIPPRP----------------------VKRAGGDYSRLSGDLSPVFGNEDDKERPP 853

  Fly   800 NLTPLKNGAAPGSVHSNHSSPSSTASPKQNNVEAAAAAAATTQSVVNRIWYEQVASTQSEYYAQP 864
            .:.|....:.|||     .:||......|......:||:....|.::....:.:.:|||  :|..
Zfish   854 QIPPRDPFSQPGS-----RTPSPHVGSPQTRSSLCSAASIYGSSYLSTSPAKLMPTTQS--FASD 911

  Fly   865 PTEQAEEQIYQNHRHQQQQQQELNHSFVAISNRVVAPKNNAYSSTASLYDAVAASTAGSTYYGQV 929
            |...|.:.|....:.::..:.......|....:|                       .:|:|
Zfish   912 PKYAAPKVIQAQGKDKEPTKGPCILPIVRDGKKV-----------------------SNTHY--- 950

  Fly   930 PNGSGAVLYDEVTQDDYLRPTRPAPL---------APPPLSAQQIQRRMEKMRLQQQQQL----- 980
                            ||.|.||..|         |......:|:.....|..:.|..:|
Zfish   951 ----------------YLLPERPPYLDRYDKFFREAECGEEKKQVNTATVKPMVHQHGELKSNFS 999

  Fly   981 ---------------------------DGAHQLYAPVPSDYGREQEKLQQLMQELGSSAVEQDVR 1018
                                       ||:   :....|::.|     .:|:||.......::..
Zfish  1000 SNNNSSLTASGFRGGLKSSFSLCRVSSDGS---FNKADSNHDR-----VRLVQEAVHGVTIEECL 1056

  Fly  1019 NALRAASGDVGLATRHYKIDQLARLGVAGRPQCEQALQQTNWSLEVAAELLLNA 1072
            .||:..|.:|..|..:.|::||..||:..|.:|:|.|:..:|:||:|:..:|::
Zfish  1057 TALQNHSWNVQKAVHYLKVEQLFCLGLKTRLECQQILEMYDWNLELASTQMLDS 1110

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack	NP_647859.1	SAM_TNK-like	14..75	CDD:188938	35/66 (53%)
		PTKc_Ack_like	128..385	CDD:270636	169/256 (66%)
		UBA_TNK1	1031..1070	CDD:270513	14/38 (37%)
tnk2b	XP_021336227.1	SAM_TNK-like	32..93	CDD:188938	35/60 (58%)
		PTKc_Ack_like	153..410	CDD:270636	169/257 (66%)
		SH3	416..464	CDD:214620	22/47 (47%)
		GTPase_binding	470..537	CDD:312537	8/66 (12%)
		Atrophin-1	<609..750	CDD:331285	39/195 (20%)
		Inhibitor_Mig-6	851..925	CDD:314449	17/80 (21%)
		UBA_ACK1	1039..1082	CDD:270460	12/47 (26%)
		UBA_TNK1	1069..1108	CDD:270513	14/38 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	366	1.000	Domainoid score	I873
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	551	1.000	Inparanoid score	I1100
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1008736at2759
OrthoFinder	1	1.000	-	-		FOG0002936
OrthoInspector	1	1.000	-	-		otm26481
orthoMCL	1	0.900	-	-		OOG6_106253
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3854
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.970