Protein Alignment Ack and Tnk2

DIOPT Version :10

• Sequence 1: NP_647859.1
• Gene: Ack / 38489
• FlyBaseID: FBgn0028484
• Length: 1073
• Species: Drosophila melanogaster
• Sequence 2: XP_006522395.1
• Gene: Tnk2 / 51789
• MGIID: 1858308
• Length: 1087
• Species: Mus musculus
• Alignment Length: 1174
• Identity: 394/1174 - (33%)
• Similarity: 544/1174 - (46%)
• Gaps: 234/1174 - (19%)

  Fly    11 LGSE-------TAWLEDLLREVQLEQFLDRIRDDLQVTRLAHFDYVLPDDLERCGLGKPAIRRLM 68
            |||.       |.||.:||.||||:|:..|:||||.:|||:||:||..:|||:.|:|:|..|||.
Mouse    28 LGSSSMQPEEGTGWLLELLSEVQLQQYFLRLRDDLNITRLSHFEYVKNEDLEKIGMGRPGQRRLW 92

  Fly    69 EAVRKKKAHQWRKNILSKLIGG----GKQPSSKKQSSAARESS-----QGNGT--QLTCLIHEKD 122
            |||:::||...||:.:||:..|    .:.||...||:..:.|.     .|.||  .|||||.|||
Mouse    93 EAVKRRKAMCKRKSWMSKVFSGKRLEAEFPSQHSQSTFRKPSPTPGSLPGEGTLQSLTCLIGEKD 157

  Fly   123 ITMGLKLGDGSFGVVRRGEWSASPAGKVIPVAVKVLKSDNLTQPGIIDDFFREVQAMHALDHANL 187
            :.:..|||||||||||||||.| ||||.:.||||.||.|.|:||..:|||.|||.|||:|||.||
Mouse   158 LRLLEKLGDGSFGVVRRGEWDA-PAGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNL 221

  Fly   188 VRLYGVVLSQPMMMITELAERGSLLDTLRKQCRHTSLTIIWNWSVQIVTGMAYLEQKRFLHRDLA 252
            :|||||||:.||.|:||||..|||||.|||...|..|..:..::||:..||||||.|||:|||||
Mouse   222 IRLYGVVLTLPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMAYLESKRFIHRDLA 286

  Fly   253 CRNVLLAAGNKIKIGDFGLMRALPQEDDCYVMSEHKKVPFPWCAPESLRFRQFSHASDTWMFGVT 317
            .||:|||..:.:|||||||||||||.||.|||.||:||||.|||||||:.|.|||||||||||||
Mouse   287 ARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVT 351

  Fly   318 LWEMFSFGEDPWVGLNGSQILRKIDREGERLHQPDACPPDVYAMMLQCWDKTPAERPTFAALKEY 382
            |||||::|::||:||||||||.|||:|||||.:|:.||.|:|.:|:|||...|.:||||.||:::
Mouse   352 LWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDF 416

  Fly   383 LASMSPPVMRASRSHHESKGLQIEPGDTIAIIDGRHELKLIKGQNQRTFDIGIFPRNLLEQRKVG 447
            |....|..|||.:...|...|.|:..|.|.:|:||.|....:|||.||..:|.||||::......
Mouse   417 LLEAQPTDMRALQDFEEPDKLHIQMNDVITVIEGRAENYWWRGQNTRTLCVGPFPRNVVTSVAGL 481

  Fly   448 AAGDV---VMRSSVGNGSSSSPFGFCWGGAAAMANGDDR--QRKCASMTNQPHAKERKSTSSKQF 507
            :|.|:   :..|.:..|...|....|||       ..||  :....:..:.|.....:.::|:
Mouse   482 SAQDISQPLQNSFIHTGHGDSDPRHCWG-------FPDRIDELYLGNPMDPPDLLSVELSTSR-- 537

  Fly   508 AYNKLVNDSATGLQRRNAVKHKGVVVGPQRPPPPQFQQEGILIDISPDMRPIAEAGTGGAKGAGD 572
                             ..:|.|.|   :|.|||:..|..|... .|...|::|          |
Mouse   538 -----------------PTQHLGRV---KREPPPRPPQPAIFTQ-KPTYDPVSE----------D 571

  Fly   573 SSSLQADSSFCILDAP------------IDVP-TYAGSSGSGDLNVSPTYYNEQP---------- 614
            ...|.:|.....|..|            ..|| |.|..|..|::.:..  :.|:|
Mouse   572 PDPLSSDFKRLGLRKPALPRGLWLAKPSARVPGTKADRSSGGEVTLID--FGEEPVVPTPRPCAP 634

  Fly   615 ---QFDFDPAKM-----TASPGRLQPPPYQMPPTYSNTMEFVQKRDLHQQQLATP------VRER 665
               |...|...:     ..||.|..|.|....|..          |...:.|..|      .::.
Mouse   635 SLAQLAMDACSLLDKTPPQSPTRALPRPLHPTPVV----------DWDARPLPPPPAYDDVAQDE 689

  Fly   666 DPFDTTNVETTVALYSNFNQSLEAASPPAPIYNS-------------PSVRKSLF----GGSK-- 711
            |.|:..::.:|:         :.|..|..|....             |::..:||    ||.|
Mouse   690 DDFEVCSINSTL---------VGAGLPAGPSQGETNYAFVPEQAQMPPALEDNLFLPPQGGGKPP 745

  Fly   712 ---SNKENIPALESAAM---QLNLSNLTLERHDATCIQPVEPVPAPPGDGVLLDKSFI------- 763
               ...|...||:...|   |:....||             |.|.|.||    ||..:
Mouse   746 SSVQTAEIFQALQQECMRQLQVPTGQLT-------------PSPTPGGD----DKPQVPPRVPIP 793

  Fly   764 -----AELEKDMYSNGQNRAQEEYQRNSTQMYASKDMVYKQNL---TPLKNGAAPGS---VHSNH 817
                 ..:|.....:|:..........|......::.:..|..   :||   ..|||   .|...
Mouse   794 PRPTRPRVELSPAPSGEEETSRWPGPASPPRVPPREPLSPQGSRTPSPL---VPPGSSPLPHRLS 855

  Fly   818 SSPSST--------ASPKQNNVEAAAAAAATTQSVVNRIWYEQVASTQSEYYAQPPTEQAEEQIY 874
            |||..|        :.||....:...|........:..|..:....:.:.||..|......|: |
Mouse   856 SSPGKTMPTTQSFASDPKYATPQVIQAPGPRAGPCILPIVRDGRKVSSTHYYLLPERPPYLER-Y 919

  Fly   875 QNHRHQQQQQQELNHSFVAISNRVVAPKNNAYSS-TASLYDAVAASTAGSTYYGQVPNGSGAVLY 938
            |....:.|..:|  .:.:.:...:..|...|.:: ||::.....|:......:....:..||
Mouse   920 QRFLREAQSPEE--PAALPVPPLLPPPSTPAPAAPTATVRPMPQAAPDPKANFSTNNSNPGA--- 979

  Fly   939 DEVTQDDYLRPTRPAPLAPPPLSAQQIQRRMEKMRLQQQQQLDGAHQLYAPVPSDYGREQEKLQQ 1003
                :...||.|...|....|...|:..|..:|:                              |
Mouse   980 ----RPPSLRATARLPQRGCPGDGQEAARPADKV------------------------------Q 1010

  Fly  1004 LMQELGSSAVEQDVRNALRAASGDVGLATRHYKIDQLARLGVAGRPQCEQALQQTNWSLEVAAEL 1068
            ::|.:......::.:.||::.|..|..|.::.|::||..||:..|.:|.:.|:..:|:||.|...
Mouse  1011 MLQAMVHGVTTEECQAALQSHSWSVQRAAQYLKVEQLFGLGLRPRVECHKVLEMFDWNLEQAGCH 1075

  Fly  1069 LLNA 1072
            ||.:
Mouse  1076 LLGS 1079

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ack	NP_647859.1	SAM_TNK-like	14..75	CDD:188938	34/67 (51%)
		PTKc_Ack_like	128..385	CDD:270636	175/256 (68%)
		UBA_TNK1	1031..1070	CDD:270513	13/38 (34%)
Tnk2	XP_006522395.1	SAM_TNK-like	38..99	CDD:188938	34/60 (57%)
		PTKc_Ack_like	162..419	CDD:270636	175/257 (68%)
		SH3_9	427..476	CDD:434066	20/48 (42%)
		GTPase_binding	481..546	CDD:430374	15/93 (16%)
		PHA03247	<626..1004	CDD:223021	76/426 (18%)
		Inhibitor_Mig-6	821..887	CDD:463294	15/68 (22%)
		UBA_ACK1	1008..1051	CDD:270460	11/72 (15%)
		UBA_TNK1	1038..1077	CDD:270513	13/38 (34%)