DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ack and Shark

DIOPT Version :9

Sequence 1:	NP_647859.1	Gene:	Ack / 38489	FlyBaseID:	FBgn0028484	Length:	1073	Species:	Drosophila melanogaster
Sequence 2:	NP_524743.2	Gene:	Shark / 44353	FlyBaseID:	FBgn0015295	Length:	939	Species:	Drosophila melanogaster

Alignment Length:	436	Identity:	137/436 - (31%)
Similarity:	199/436 - (45%)	Gaps:	94/436 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 STSAVDGGLGSETAWLEDLLR--------EVQLEQFLDRIRDDLQVTRLAHFDYVLPDDLERCGL 59
            ||...||..||..|...::..        |:.|.....:..        |..:|....|:
  Fly   527 STFNADGVTGSGAAAAGEVYNVPRNNTPIEIDLPPIAQKTE--------AEVEYFTKSDV----- 578

  Fly    60 GKPAIRRLMEAVRKKKAHQWRKNILSKLIGGGKQPSSK---------KQSSAARESSQG------ 109
                      |:.:::|.||        ||.|.||:..         |..:.||.:|.|
  Fly   579 ----------AIERERAGQW--------IGNGYQPTMDVLSLLDQQIKAPAVARLNSLGPNASTE 625

  Fly   110 -----------NGT------------QLTCLIHEKDITMGLKLGDGSFGVVRRGEW--SASPAGK 149
                       :||            :|...|..:.:.:..::|.|.||.|..| |  ..|.||:
  Fly   626 SEMASYLHRKCSGTPSTPSATEVEAAKLRFFIEPEKLVLDREIGHGEFGSVHSG-WLLRKSGAGE 689

  Fly   150 V--IPVAVKVLKSDNLTQPGIIDDFFREVQAMHALDHANLVRLYGVVLSQPMMMITELAERGS-- 210
            .  :.||:|:|..::..:    .:|.||...|..|:|..:|||.|:...:.:||:.|||..||
  Fly   690 ESRLEVAIKMLSDEHSNK----QEFLREASVMMRLEHKCIVRLIGIAKGEMLMMVQELAPLGSML 750

  Fly   211 --LLDTLRKQCRHTSLTIIWNWSVQIVTGMAYLEQKRFLHRDLACRNVLLAAGNKIKIGDFGLMR 273
              :||...:...:..|.:   |:.||..||.|||.:.|:|||||.||:||.|.::.||.|||:.|
  Fly   751 QYILDHGHEITANAELKV---WASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSR 812

  Fly   274 ALPQEDDCYVMSEHKKVPFPWCAPESLRFRQFSHASDTWMFGVTLWEMFSFGEDPWVGLNGSQIL 338
            :|......|..::..:.|..|.||||.....||||||.|.||||:|||||.|..|:..::....:
  Fly   813 SLRPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAI 877

  Fly   339 RKIDREGERLHQPDACPPDVYAMMLQCWDKTPAERPTFAALKEYLA 384
            :.:| .||||.||:.||..:||:|..||.:.|.:||||..|.|:.|
  Fly   878 KLVD-SGERLPQPNLCPAYIYAVMQSCWKERPKDRPTFVYLTEFFA 922

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack	NP_647859.1	SAM_TNK-like	14..75	CDD:188938	7/68 (10%)
		PTKc_Ack_like	128..385	CDD:270636	107/265 (40%)
		UBA_TNK1	1031..1070	CDD:270513
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210
		Ank_2	<112..184	CDD:289560
		ANK	117..241	CDD:238125
		ANK repeat	124..151	CDD:293786
		ANK repeat	153..184	CDD:293786
		Ank_2	158..247	CDD:289560
		ANK repeat	186..217	CDD:293786
		ANK repeat	220..245	CDD:293786
		Ank_4	224..274	CDD:290365
		SH2_Cterm_shark_like	287..395	CDD:198211
		TyrKc	662..921	CDD:197581	106/267 (40%)
		PTKc_Syk_like	666..926	CDD:270650	107/266 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468378
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940