DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ack and Egfr

DIOPT Version :10

Sequence 1:NP_647859.1 Gene:Ack / 38489 FlyBaseID:FBgn0028484 Length:1073 Species:Drosophila melanogaster
Sequence 2:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster


Alignment Length:621 Identity:174/621 - (28%)
Similarity:258/621 - (41%) Gaps:142/621 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    95 SSKKQSSAARESSQGNGTQLTCLIHEKDITMGLKLGDGSFGVVRRGEWSASPAGKVIPVAVK-VL 158
            |..:.|...|.|:.|.......::.:.::..|..||.|:||.|.:|.|........||||:| :|
  Fly   910 SGCEDSEPLRPSNIGANLCKLRIVKDAELRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIKELL 974

  Fly   159 KSDNLTQPGIIDDFFREVQAMHALDHANLVRLYGVVLSQPMMMITELAERGSLLDTLRKQCRHTS 223
            ||   |.....::|.||...|.:::|.||::|..|.:|..||:||:|...|.|||.:|.......
  Fly   975 KS---TGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQMMLITQLMPLGCLLDYVRNNRDKIG 1036

  Fly   224 LTIIWNWSVQIVTGMAYLEQKRFLHRDLACRNVLLAAGNKIKIGDFGLMRALPQEDDCYVMSEHK 288
            ...:.|||.||..||:|||:||.:|||||.||||:...:.:||.||||.:.|..:.     :|:|
  Fly  1037 SKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDS-----NEYK 1096

  Fly   289 ----KVPFPWCAPESLRFRQFSHASDTWMFGVTLWEMFSFGEDPWVGLNGSQILRKIDREGERLH 349
                |:|..|.|.|.:|.|.|:..||.|.||||:||:.:||:.|...:....|...|: .|.:|.
  Fly  1097 AAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIE-VGLKLE 1160

  Fly   350 QPDACPPDVYAMMLQCWDKTPAERPTFAALKEYLASMSPPVMRASRSHHESKGLQIEPGDTIAII 414
            ||:.|..|:|..:|.||....|.||||..|....|..:.                 :||..:||.
  Fly  1161 QPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFAR-----------------DPGRYLAIP 1208

  Fly   415 -DGRHELKLIKGQNQRTFDIGIFPRNLLEQRKVGAAGDVVMRSSVGNGSSSSPFGFCWGGAAAMA 478
             |....|.....|::         ::|:  ||:....|                     |:.|:|
  Fly  1209 GDKFTRLPAYTSQDE---------KDLI--RKLAPTTD---------------------GSEAIA 1241

  Fly   479 NGDD-RQRKCASMTNQPHAKERKSTSSKQFAYNKLVND-----SATGLQRRNAVKHKGVVVGPQR 537
            ..|| .|.|.|     |....|...:.:....|:...|     |:||....:: ..:.|.||..|
  Fly  1242 EPDDYLQPKAA-----PGPSHRTDCTDEIPKLNRYCKDPSNKNSSTGDDETDS-SAREVGVGNLR 1300

  Fly   538 PPPPQFQQEGILIDISPDMRPIAE-------------AGTGGAKGAGDSSSLQADSSFCILDAPI 589
            ...|..:.:.::    |..:|...             |..|.|.|..|           ::..|:
  Fly  1301 LDLPVDEDDYLM----PTCQPGPNNNNNINNPNQNNMAAVGVAAGYMD-----------LIGVPV 1350

  Fly   590 DV--PTY---AGSSGSGDLNVSPTYYNEQPQFDFDPAKMTASPGRLQ---PPPYQMPPT-----Y 641
            .|  |.|   |.:.|.|:..: ||.....|        :...||.::   |.|...|.:     |
  Fly  1351 SVDNPEYLLNAQTLGVGESPI-PTQTIGIP--------VMGVPGTMEVKVPMPGSEPTSSDHEYY 1406

  Fly   642 SNTMEFVQKRDLHQQQLATPVRERDPFDTTNVETTV 677
            ::|...:|  .||:.:              |.||.|
  Fly  1407 NDTQRELQ--PLHRNR--------------NTETRV 1426

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AckNP_647859.1 SAM_TNK-like 14..75 CDD:188938
PTKc_Ack_like 128..385 CDD:270636 105/261 (40%)
UBA_TNK1 1031..1070 CDD:270513
EgfrNP_476759.1 Recep_L_domain 128..239 CDD:460032
Furin-like 253..401 CDD:395614
Recep_L_domain 419..547 CDD:460032
GF_recep_IV 572..684 CDD:464344
FU 662..716 CDD:214589
GF_recep_IV 740..>834 CDD:464344
PTKc_EGFR_like 930..1208 CDD:270648 110/303 (36%)
Blue background indicates that the domain is not in the aligned region.

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