Protein Alignment Ack and Fak

DIOPT Version :10

• Sequence 1: NP_647859.1
• Gene: Ack / 38489
• FlyBaseID: FBgn0028484
• Length: 1073
• Species: Drosophila melanogaster
• Sequence 2: NP_001137718.1
• Gene: Fak / 37233
• FlyBaseID: FBgn0020440
• Length: 1500
• Species: Drosophila melanogaster
• Alignment Length: 1139
• Identity: 253/1139 - (22%)
• Similarity: 412/1139 - (36%)
• Gaps: 347/1139 - (30%)

  Fly    88 IGGGKQPSSKKQSSAARESS-----QGNGTQLTCLI--HEKD---ITMGLKLGDGSFGVVRRGEW 142
            :|..|..||:.:.....:.:     :|.|...|..:  :|.|   ||...|:|.|.||.|..|.:
  Fly   412 LGSNKSTSSQGKPMLTDDYAEIGLLEGEGDYSTPTVRNYELDRALITPSAKIGVGQFGDVYVGTY 476

  Fly   143 SASPAGK-----------------------VIPVAVKVLKSDNLTQPGIIDDFFREVQAMHALDH 184
            :....||                       ||.||:|..|:::  .|...::|..|...|...||
  Fly   477 TLPKLGKGKNLAGNGKNSNSDQRNADSRPDVIQVAIKTCKAND--DPEKTENFLAEAYIMQKFDH 539

  Fly   185 ANLVRLYGVVLSQPMMMITELAERGSLLDTLRKQCRHTSLTIIWNWSVQIVTGMAYLEQKRFLHR 249
            .:::||.|:....|:.::.|||:.|.|...|:......|...:..:..|:.|.::|||.|:|:||
  Fly   540 PHIIRLIGICSVMPIWIVMELAKLGELRAYLKTNSERLSHGTLLKYCYQLSTALSYLESKKFVHR 604

  Fly   250 DLACRNVLLAAGNKIKIGDFGLMRALPQEDDCYVMSEHKKVPFPWCAPESLRFRQFSHASDTWMF 314
            |:|.||||:::...:|:.||||.|.: .:...|..:....:|..|.:|||:.||:|:.|||.|||
  Fly   605 DIAARNVLVSSPTCVKLADFGLSRWV-SDQSYYHSTPTVALPIKWMSPESINFRRFTTASDVWMF 668

  Fly   315 GVTLWEMFSFGEDPWVGLNGSQILRKIDREGERLHQPDACPPDVYAMMLQCWDKTPAERPTFAAL 379
            ||.:||:...|..|:.|:..|.::.|:: .||||..|..|||.:|::|.|||...|.:||.|..:
  Fly   669 GVCIWEILMLGVKPFQGVKNSDVILKLE-NGERLPLPPNCPPRLYSLMSQCWAYEPLKRPNFKRI 732

  Fly   380 KEYL----------------------ASMS---------PPVMRASRSHHESKGLQIEPGDTIAI 413
            ||.|                      ||||         || .:.||..|:.....:.|..|
  Fly   733 KETLHEILIEDSINSSETLKREQRKVASMSWIGSDDIDIPP-SKPSRVMHDPDITGLMPETT--- 793

  Fly   414 IDGRHELKLIKGQNQRTFDIGIFPRNLLEQRKVGAAGDVVMRSSVGNGSSSSPFGFCWGGAAAMA 478
              |..:..:| .||.     .:..:.::|.:|.|          :...:.::|....  ...|:.
  Fly   794 --GLPQTYII-AQNP-----AVLAKLMMENQKRG----------INPAAYTTPASVF--NTLAVG 838

  Fly   479 NGDDRQRKCASMTNQPHA----------KER-KSTSSKQFAYNKLVNDSATGLQRRNAV-KHK-G 530
            ..|.........|..|.|          .|| :|..|...:.::|.|.....:....:: .|: |
  Fly   839 LDDSNPNVSLKTTKLPAADLLKLDPIAESERLRSQFSANSSASQLANPLTASVNPHESLNSHQAG 903

  Fly   531 VVVG--PQRPP----PPQFQQEGILIDIS-PDMRPIAEAGTGGAKGAGDSSSLQADSSFCILDAP 588
            :..|  |.:..    |||.::.....:|| |.:                 |.:...|.:..|:..
  Fly   904 MFTGSLPSKSSFVVCPPQTEEHMQAENISNPSV-----------------SKVSGYSLYGSLERH 951

  Fly   589 IDVPTYAGSSGSGDLN--------VSPTYYNEQPQFDFDPAKMTASPGRLQPPPYQMPPTYSNTM 645
            ...|..|..|..|.|.        .:..:||.:|                       ||..:||.
  Fly   952 QPPPAKAMHSKGGSLERHQSLMSAQNLVFYNTKP-----------------------PPNCTNTA 993

  Fly   646 EFVQKRDL--------HQQQLATPV------RERDPFDTTNVETTVALYSNFNQSLEAASPP--A 694
            |  :.|.:        ::||:.|.:      .|...|....::|.|:          |...|  :
  Fly   994 E--RSRSMERNTYFHAYRQQMKTSIECEALPEEIYDFGGIGLKTCVS----------ARQQPKFS 1046

  Fly   695 PIYNSPSVRKSLFGGSKSN-----KENIP--------------------ALESAAMQLNLSNLTL 734
            |:.|   ||.:..|..::.     ::|||                    .:|...|.....::|:
  Fly  1047 PMVN---VRPAELGQVQNTDCMGLQQNIPMDSFGVISPHNLDESLRHQREMERQWMTSGPQSITV 1108

  Fly   735 E-----RHDATCIQPVEPVPAPPGDG---VLLDKSFIAELEKDMYSNGQNRAQEEYQR------- 784
            .     ...|.|:..:: ..|....|   ||.:|  :.:.:||..|:.:...|||..|
  Fly  1109 NPNISISEGAACLATLQ-AEAMGNQGIHNVLGEK--LRQQQKDSNSDSEWLIQEELLRSCSIPQG 1170

  Fly   785 ----NSTQMY------------------ASKDMVYKQNLTPLKNGAAPGSVHSNHSSPSSTASPK 827
                :..||:                  :|:.|....||:.||         |||||....:|
  Fly  1171 SLNDHQAQMFKLDFMSAGPSSLPDCSNSSSRPMTPNANLSSLK---------SNHSSADHLSS-- 1224

  Fly   828 QNNVEAAAAAAATTQSVVNRIWYEQVASTQSEYYAQPPTEQAEEQIYQNHRHQQQQQQELNHSFV 892
                                                  ...||||:..|.|:...
  Fly  1225 --------------------------------------LTSAEEQMGSNARNLGS---------- 1241

  Fly   893 AISNRVVAPKNNA----YSSTASLYDAVAASTAG-----STYYGQVPNGSGAVLYDEVTQDDYLR 948
            |:.:|   |.|.|    |.:|..:..::.|.:.|     :..|.::....|..|.:.:|..|.:.
  Fly  1242 AVPSR---PPNRADDEVYCATTLVVKSIMALSQGVEKANTEGYLELVKNVGVKLRNLLTSVDKIS 1303

  Fly   949 PTRPAPLAPPPLSAQQIQRR-----MEKMRLQQQ------------QQLDGAHQLYAPVPSDYGR 996
            ...||........|.|:..:     :..|||.||            ..|..||.|.....:.:.
  Fly  1304 IIFPAQALKEVQMAHQVLSKDMHELVSAMRLAQQYSDTTLDCEYRKSMLSAAHVLAMDAKNLFD- 1367

  Fly   997 EQEKLQQLMQEL--GSSAVEQDVRNALRAASGDV 1028
            ..:.::|..|.|  .|:..|....::..:.||.:
  Fly  1368 VVDSIRQRYQHLFPPSATKETSCSSSFESTSGSI 1401

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ack	NP_647859.1	SAM_TNK-like	14..75	CDD:188938
		PTKc_Ack_like	128..385	CDD:270636	97/301 (32%)
		UBA_TNK1	1031..1070	CDD:270513
Fak	NP_001137718.1	B41	24..267	CDD:214604
		FERM_B-lobe	152..257	CDD:271216
		FERM_C_FAK1	263..394	CDD:270011
		PTKc_FAK	450..744	CDD:133187	101/297 (34%)
		Focal_AT	1250..1376	CDD:460992	24/126 (19%)