Protein Alignment Ack and Ack-like

DIOPT Version :10

• Sequence 1: NP_647859.1
• Gene: Ack / 38489
• FlyBaseID: FBgn0028484
• Length: 1073
• Species: Drosophila melanogaster
• Sequence 2: NP_001260935.1
• Gene: Ack-like / 36442
• FlyBaseID: FBgn0263998
• Length: 1495
• Species: Drosophila melanogaster
• Alignment Length: 1249
• Identity: 306/1249 - (24%)
• Similarity: 486/1249 - (38%)
• Gaps: 305/1249 - (24%)

  Fly    18 LEDLLREVQLEQFLDRIRDDLQVTRLAHFDYVLPDDLERCGLGKPAIRRLMEAVRKKKAHQWRKN 82
            |.:.|.|.:|:|:.:.::::|::|..|.|.|...:||...||.:|.||||.:...|...|.:...
  Fly     8 LYEFLTESELQQYYNAVKNELKITNAAQFKYAADEDLRFIGLSRPEIRRLRKFYEKHFPHSYLSK 72

  Fly    83 ILSKLI-------------GGGKQPSSKKQSSAARES-SQGNGTQLTC-------LIHEKDITMG 126
            | .:|:             |||.|.:....|::|..| :..||.....       :|....|::.
  Fly    73 I-KRLLQAPGTMVKREEAPGGGSQVALDGSSASACSSLAAKNGASSPSKVPNNKHIIPADSISVN 136

  Fly   127 LKLGDGSFGVVRRGEWSASPAGKVIPVAVKVLKSDNLTQPGIIDDFFREVQAMHALDHANLVRLY 191
            .:||.|.||:|::|.|  |...:.|.||:|.|..:.:....:  :|.:|...||:::|.|:||||
  Fly   137 KQLGTGEFGIVQQGVW--SNGNERIQVAIKCLCRERMQSNPM--EFLKEAAIMHSIEHENIVRLY 197

  Fly   192 GVVL-SQPMMMITELAERGSLLDTLRKQ-CRHTSLTI--IWNWSVQIVTGMAYLEQKRFLHRDLA 252
            |||| :..:|::||||...|||:.|:.. .|.:.|||  :..:::||..||.||||||.:|||||
  Fly   198 GVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLA 262

  Fly   253 CRNVLLAAGNKIKIGDFGLMRALPQEDDCYV--MSEHKKVPFPWCAPESLRFRQFSHASDTWMFG 315
            .||:|:.:.:|:||.||||.|||....|.|.  .:.:.|:|..|||||.:.:.:|::|||.|.||
  Fly   263 ARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFG 327

  Fly   316 VTLWEMFSFGEDPWVGLNGSQILRKIDREG-ERLHQPDACPPDVYAMMLQCWDKTPAERPTFAAL 379
            |.||||||:|..||..|.|.|||..||... :||.|||.||.:.|.:|::||....|:||.|..:
  Fly   328 VCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEI 392

  Fly   380 KEYLASMSPPVMRA-------SRSH-------------------------HESKGLQIEPGDTIA 412
            .:.|..|.|..::|       .:.|                         ...|.....|.:|:|
  Fly   393 YDQLPDMKPEQLKAVVNCTEPKKDHLLYRQGDIISVLDRNTGTPFWKGVLSTGKTGYFNPSNTVA 457

  Fly   413 IIDG----------------------RHELKLIKGQN--QRTFDIGI------------------ 435
            .::|                      |.|: :.|.||  :.|..:||
  Fly   458 FLEGLPSSTRDSFSRVSDHRISKRKLRTEM-ISKPQNDFKHTGHVGIDGATFGDIAFLGSSQNYN 521

  Fly   436 -FPRNL---------LEQRKV---------------------GAAGDVVMRSSVG---------- 459
             .|:.:         :||..:                     ||.....|.:|:.
  Fly   522 HVPKQIVTPYKPSEDIEQTPLLLPPTPTSPDSLQTASGYFPEGANSGGAMGTSMNPTFIPSAEHT 586

  Fly   460 ------NGSSSSPFGFCWGGAAAM--ANGDDR---------------------QRKCASMTNQPH 495
                  ||.||  |.|..|.....  ..|||.                     :....|:.:.||
  Fly   587 PKLIATNGQSS--FDFASGSTNPFFPNRGDDELEFGLHNYGADGKSVHSETGWRPTSRSIVDDPH 649

  Fly   496 AKERKSTSSKQFAYNKL---------VN------DSATGLQRRNAVKHKGVVVGPQRPPPPQFQQ 545
              |....|..:.|.:||         :|      .:|||       .|      |:.|.......
  Fly   650 --EYHEISDDEIAADKLDFGPSLLDEINSMFGSISAATG-------SH------PKSPGFDHVNN 699

  Fly   546 EGILIDISPDMRPIAEAGTGGAKGAGDSSSLQADSSF-----------CILDAPIDVPTYAGSSG 599
            :..:.::|..:...:....|...|.|...:|....|.           .||:..|::.....:..
  Fly   700 KNEITEMSAKLGQKSGDTNGNKHGHGLLPTLSKKKSSGTVKPISVKDEKILNHAIEIANEISARS 764

  Fly   600 SGDL--NVSPTYYNEQPQFDFDPAKMTAS-----PGRLQPPPYQMPPTYSNTMEFVQKRDLHQQQ 657
            ..||  :.:|..::.:.:|.|....::.:     .|.|........||:.|...|.:|::..::.
  Fly   765 MIDLVSDQTPVIHSPKRKFSFRFPHLSNNGSGDKSGGLGTSGSAHTPTHGNASPFPKKKNFTEEL 829

  Fly   658 LATP--VRERDPFDTTN-VETTVALYSN------FNQSLEAASPPAPIYNSPSVRKSLFGGSKSN 713
            .:.|  .|.|...:..| .:..|.::..      |.:|.|..|.|..:.......:.    .||.
  Fly   830 QSIPDIQRFRSLSEIKNSTDLRVPIFDKESSDFLFQKSREILSRPLNLERECGDEQP----PKSI 890

  Fly   714 KENIPALESAAMQLNLSNL----TLERHDA--TCIQPVEPVPAPPGDGVLLDKSFIAELEKDMYS 772
            .:||..:|:....|||..:    .|::.|:  |.:....|..|...||:   .|....|:..:||
  Fly   891 DDNIMDIENTLKALNLDFMHTYTELDKSDSNDTILNDQLPHMASLDDGI---SSATGSLKSAVYS 952

  Fly   773 NGQNRAQEEYQRNSTQMYASKDMVYKQNLTPLKNGAAPGSVHSNHSSPSSTASPKQNNVEAAAAA 837
            . .|..|..:..|:...:..|.:.|..|...| :.|||       ..|......:.:..:...|:
  Fly   953 Y-SNGVQTMFDFNAATSHLDKHLQYMHNQAQL-SAAAP-------VDPKPMDDKRSSTPDTGFAS 1008

  Fly   838 AATTQSVVNRIWYEQVASTQSEY---------YAQPPTEQA-------EEQIYQNHRHQQQQQQE 886
            ..|..|:..|...:...|.|..:         ::.||...:       :|..|:...:...:|..
  Fly  1009 RDTNISLSRRSSQKSSYSPQESFHFPLKGEPLFSAPPVVMSGGYASLKDELGYERFGNGATKQML 1073

  Fly   887 LNHSFVAISNRVVAPKNNAYSSTASLYDAVAASTAGSTYYGQVPNGSGAVLYDEVTQDDYLRPTR 951
            .:.|          |..:.....||         :||.|.|.......:..::|     ...|..
  Fly  1074 ASAS----------PIKSGVGLNAS---------SGSVYMGSKGYRQRSTSFNE-----SFHPIS 1114

  Fly   952 PAPLAPPPLSAQQIQRRMEKMRLQQQQQLDGAHQLYAPVPSDYGREQEKL--QQLMQELGSSAVE 1014
            |....||......|||   ::||:|||.|......|.| .|...|...:|  ..:..:..||:.|
  Fly  1115 PVLSEPPQRERGVIQR---QVRLEQQQPLPRRSASYKP-RSIRARTLRRLSYNPMTLDSSSSSGE 1175

  Fly  1015 QDVRNALRAASGDV 1028
            :.|:.:|..:..|:
  Fly  1176 EPVKPSLARSECDI 1189

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ack	NP_647859.1	SAM_TNK-like	14..75	CDD:188938	20/56 (36%)
		PTKc_Ack_like	128..385	CDD:270636	118/263 (45%)
		UBA_TNK1	1031..1070	CDD:270513
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	20/56 (36%)
		PTKc_Ack_like	137..398	CDD:270636	118/264 (45%)
		SH3	400..454	CDD:214620	5/53 (9%)
		CRIB	486..525	CDD:238077	7/39 (18%)