Protein Alignment Ack and Btk

DIOPT Version :10

• Sequence 1: NP_647859.1
• Gene: Ack / 38489
• FlyBaseID: FBgn0028484
• Length: 1073
• Species: Drosophila melanogaster
• Sequence 2: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Alignment Length: 274
• Identity: 108/274 - (39%)
• Similarity: 157/274 - (57%)
• Gaps: 23/274 - (8%)

  Fly   118 IHEKDITMGLKLGDGSFGVVRRGEWSASPAGKVIPVAVKVLKSDNLTQPGIIDDFFREVQAMHAL 182
            ||..::.:..:||.|.|||||||:|..|     |..|||::|...:::    |||..|.:.|..|
  Fly   521 IHPMELMLMEELGSGQFGVVRRGKWRGS-----IDTAVKMMKEGTMSE----DDFIEEAKVMTKL 576

  Fly   183 DHANLVRLYGVVLS-QPMMMITELAERGSLLDTLRKQCRHTSLTIIWNWS------VQIVTGMAY 240
            .|.|||:||||... :|:.::||..:.||||:.||   ||.. |:|.|..      :|:..||.|
  Fly   577 QHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLR---RHEK-TLIGNMGLLLDMCIQVSKGMTY 637

  Fly   241 LEQKRFLHRDLACRNVLLAAGNKIKIGDFGLMRALPQEDDCYVMSEHKKVPFPWCAPESLRFRQF 305
            ||:..::|||||.||.|:.:.|.:|:.||||.|.:  .||.|..|...|.|..|..||.|.:.:|
  Fly   638 LERHNYIHRDLAARNCLVGSENVVKVADFGLARYV--LDDQYTSSGGTKFPIKWAPPEVLNYTRF 700

  Fly   306 SHASDTWMFGVTLWEMFSFGEDPWVGLNGSQILRKIDREGERLHQPDACPPDVYAMMLQCWDKTP 370
            |..||.|.:||.:||:|:.|:.|:..|..::::.::.| |..|.:|.:|..::|.:|..||...|
  Fly   701 SSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQR-GIILEKPKSCAKEIYDVMKLCWSHGP 764

  Fly   371 AERPTFAALKEYLA 384
            .|||.|..|.:.||
  Fly   765 EERPAFRVLMDQLA 778

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ack	NP_647859.1	SAM_TNK-like	14..75	CDD:188938
		PTKc_Ack_like	128..385	CDD:270636	106/264 (40%)
		UBA_TNK1	1031..1070	CDD:270513
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702
		SH2_Tec_family	403..505	CDD:198188
		PTKc_Tec_like	521..778	CDD:173637	106/272 (39%)