DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ack and ark-1

DIOPT Version :9

Sequence 1:	NP_647859.1	Gene:	Ack / 38489	FlyBaseID:	FBgn0028484	Length:	1073	Species:	Drosophila melanogaster
Sequence 2:	NP_001255654.1	Gene:	ark-1 / 178218	WormBaseID:	WBGene00000186	Length:	1043	Species:	Caenorhabditis elegans

Alignment Length:	1053	Identity:	275/1053 - (26%)
Similarity:	414/1053 - (39%)	Gaps:	230/1053 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 GSETAWLEDLLREVQLEQFLDRIRDDLQVTRLAHFDYVLPDDLERCGLGKPAIRRLMEAVRKKKA 76
            |:..|.|..||:...|..:...:|..|::...|...||...||...|:.:|..:||    ||:..
Worm     8 GTADATLNKLLQAADLSGYESDLRRKLKLRNAADLQYVEEVDLLSVGMSRPEQKRL----RKEYT 68

  Fly    77 HQWRKNILSKLIGGGKQPSS---KKQSSAARESSQGNGTQLTCLIHEKDITMGLKLGDGSFGVVR 138
            ..:...|..|:....|:..|   |..:|.|.:....:.     :|..:.||:..:||.|.||.|.
Worm    69 KMFPSGIFGKVKKAFKRAESLDRKTSNSVANQDDNDHH-----VIPIEKITLCKELGQGEFGSVW 128

  Fly   139 RGEWSASPAGKVIPVAVKVLKSDNLTQPGIIDDFFREVQAMHALDHANLVRLYGVVL-SQPMMMI 202
            :..|..|....||.||||.:.||.|....  ..|.:|...|..:.|.::|||||||| ::.:|::
Worm   129 QAGWKNSAGSDVIQVAVKCVGSDKLLATS--SSFLQEAAIMTRMRHEHVVRLYGVVLDTKKIMLV 191

  Fly   203 TELAERGSLLDTLRKQCRHTS--LTIIWNWSVQIVTGMAYLEQKRFLHRDLACRNVLLAAGNKIK 265
            :|||..||||:.|.|.....|  :.::.:::.||..||:|||.:|.:|||||.||||:.:...:|
Worm   192 SELATCGSLLECLHKPALRDSFPVHVLCDYAEQIAMGMSYLELQRLIHRDLAARNVLVFSPKLVK 256

  Fly   266 IGDFGLMRALPQEDDCYVMSE---HKKVPFPWCAPESLRFRQFSHASDTWMFGVTLWEMFSFGED 327
            |.||||.|:|...:| |..||   :.|:|..|||||.:.|.:|:..||.|.:|||:|||||:||.
Worm   257 ISDFGLSRSLGIGED-YYRSEFTPNLKLPIAWCAPECINFLKFTSKSDVWAYGVTIWEMFSYGEM 320

  Fly   328 PWVGLNGSQILRKIDREGERLHQPDACPPDVYAMMLQCWDKTPAERPTFAALKEYLASMSPPVMR 392
            ||.|.:|:|||..:||:.|.|.:|.|||.|:|.|:.:.|.....:||||:.:...........:|
Worm   321 PWKGRSGAQILELVDRKKELLTRPKACPEDIYDMLKETWTHQVQDRPTFSDIVAKFPERRAQSVR 385

  Fly   393 A------SRSHHESKGLQIEPGDTIAII--------DGRHELKLIKGQNQRTF------------ 431
            |      |.:.|    |..:..|.|.:|        ||.:....::......|
Worm   386 AVVDCKDSAADH----LHFKKDDLIVVISRSPAQYPDGYYWFGSLRNGKLGLFRPTDTVAHLGSE 446

  Fly   432 ---DIGIFPRNLLEQRKVGAAGDVVMRSSVGNGSS---SSPFG----FCWGGAAAMANG---DDR 483
               ..|.......|:.|.|.......:.|......   |.|.|    .|..|....|.|   .|:
Worm   447 PPCSNGTIENGFSEKEKGGKKNKKAEKESERERKKLLISEPVGDVRHTCHVGIDGTAFGLLQLDK 511

  Fly   484 QRKCASMTNQPHAKERKSTSSKQFAYNKLVNDSATGLQRRNAVKHKGVVVGPQRPPPPQFQQEGI 548
            :..|.  |:...:..|.|.:|.  |.:...:.:.:.:..|..|...||.:          ::...
Worm   512 KAMCP--TSSSPSTSRGSQASP--APSHTSSSTTSSVHLRETVARNGVPI----------KETMS 562

  Fly   549 LIDISPDMRPIAEAGTGGAKGAGDSSSLQADSSFCILDAPIDVPTYAGSSGSGDLNVSPTYYNEQ 613
            |.|:.|..|              |:.:|:...|..:..||...|:|:                 |
Worm   563 LRDVGPLSR--------------DALNLRDTVSPPVARAPSQPPSYS-----------------Q 596

  Fly   614 PQFDFDPAKMTASPGRLQPPPYQMPPTYSNTMEFVQKRDLHQQQLATPVRERDPFDTTNVETTVA 678
            |                :|||..:....|.....||..|    |.::..|.|.....|....|.:
Worm   597 P----------------RPPPRSVSSVSSGNQHSVQVHD----QFSSLDRSRGSLTPTAPPLTAS 641

  Fly   679 LYSNFNQSLEAASPPAPIYN----------------SP---SVRKSLFGGSKSNKENIPALES-- 722
            ..::....|...|...|..|                ||   |...:|...|.|.|:.|||...
Worm   642 AANSLKDPLTGISLSIPSNNLISYMDDQEDDHRWTRSPGAISQSTTLTALSSSRKDPIPAPRGPV 706

  Fly   723 AAMQLNLSNLTLERHDATCIQPVEPVPAPPGDGVLLDKSFIAELEKDM--YSNGQNRAQEEYQRN 785
            ||:.....::              |.||...|..|.:|  |.:|.:|:  ||.|
Worm   707 AAVYARGKDI--------------PTPASKSDIALCEK--IEDLNRDLTNYSIG----------- 744

  Fly   786 STQMYASKDMVYKQNLTPLKNGAAPGSVHSNHSSPSSTASPKQNNVEAAAAAAATTQSVVNRIWY 850
             |....|:|       .||.:     |::...|| |:|..|...:.||..           |...
Worm   745 -TICDYSED-------RPLLD-----SMNRTISS-STTHQPPPQSSEARI-----------RFMT 784

  Fly   851 EQVASTQSEYYAQPPTEQAEEQIYQNHRHQQQQQQELNH----SFVAISNRVVAPKNNAYSSTAS 911
            ||.....:|..|:  ..:..|.:.:..|.::|:..|:..    :....|.|  .|:...:||.|.
Worm   785 EQEVRKINEKSAR--EHRKTEDLLREERQKEQKPGEIEEPQQPAESLYSTR--TPQQEGWSSAAQ 845

  Fly   912 LYDAVAASTAGSTYYGQV--------PNGSGAVLYDEVTQDDYLRPTRPAPLAPPPLSAQQIQRR 968
              :|........|...|.        |..|.....|..:    :.|..|.|:. ||||   ::..
Worm   846 --EAYKLLVECGTNLKQASVSPPPMSPTSSRLSTLDRSS----ISPAPPRPVT-PPLS---VRNE 900

  Fly   969 MEKMRLQQQQQLD 981
            ...||..||::::
Worm   901 TISMRKSQQEEME 913

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack	NP_647859.1	SAM_TNK-like	14..75	CDD:188938	18/60 (30%)
		PTKc_Ack_like	128..385	CDD:270636	114/262 (44%)
		UBA_TNK1	1031..1070	CDD:270513
ark-1	NP_001255654.1	SAM_superfamily	14..71	CDD:301707	17/60 (28%)
		TyrKc	113..376	CDD:197581	116/265 (44%)
		PTKc_Ack_like	117..378	CDD:270636	114/263 (43%)
		SH3	384..434	CDD:214620	10/53 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910