DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack and kin-32

DIOPT Version :9

Sequence 1:	NP_647859.1	Gene:	Ack / 38489	FlyBaseID:	FBgn0028484	Length:	1073	Species:	Drosophila melanogaster
Sequence 2:	NP_740841.1	Gene:	kin-32 / 172135	WormBaseID:	WBGene00002213	Length:	867	Species:	Caenorhabditis elegans

Alignment Length:	421	Identity:	123/421 - (29%)
Similarity:	197/421 - (46%)	Gaps:	67/421 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SETAWLEDLLREVQLEQFLDRIRDDLQVTRLA-HFDYVLPDDL-------------ERCGLGK-P 62
            |.|:..|.::|.:.|  .|:.::.|:::.:.: ...:..|.:|             |||...: .
Worm   204 SATSPNESIIRSLAL--LLEVVKFDVELFKASLGAGWTKPVELVVGPHTGLSYRLNERCDSSRLL 266

  Fly    63 AIRRLMEAVRKKKAHQWRKNILSKLIGGGKQPSSKKQSSAARESSQG-----NGTQL-------- 114
            .:|.:.|...:|..:...|.::...:.|..:|.....|:  .|.||.     :|.|:
Worm   267 ELRTIAEITIRKMENGSEKTLMQLNLSGAAKPVLITLST--EELSQSLAHLLDGYQMLYNQRDSV 329

  Fly   115 ----------TCLIHEKD-------------------ITMGLKLGDGSFGVVRRGEWSASPAGKV 150
                      |..:||..                   ||:...:|.|.||.|.:..:......:.
Worm   330 FKLKGIERCETLTMHEATIRPKTPNNIDSNIRLRRELITLKELIGGGQFGNVYKAVYHDLEKDER 394

  Fly   151 IPVAVKVLKSDNLTQPGIIDDFFREVQAMHALDHANLVRLYGVVLSQPMMMITELAERGSLLDTL 215
            |.|||||.|:|  .:|.......:|...|....|:|:::|.||.:.|||.::.|||.:|.|.:.|
Worm   395 IAVAVKVCKTD--AEPADTQLILQESSLMRNFRHSNIIQLIGVCVDQPMWLVLELAPKGELREYL 457

  Fly   216 RKQCRHTSLTIIWNWSVQIVTGMAYLEQKRFLHRDLACRNVLLAAGNKIKIGDFGLMRALPQEDD 280
            :::.....|.|:..:..||...:.||...||:|||:|.||:|:.:...:|:.||||.|||  :.|
Worm   458 QQEKDWLPLRILTLFCSQICDSLVYLHSTRFVHRDIAARNILVCSPQCVKLADFGLSRAL--DYD 520

  Fly   281 CYVMSEHKKVPFPWCAPESLRFRQFSHASDTWMFGVTLWEMFSFGEDPWVGLNGSQILRKIDREG 345
            ....:...|:|..|.||||:.:||||.|||.|||||.:||:||.|..||.|:..|.::..|: :|
Worm   521 AVYTASRGKLPIKWLAPESVNYRQFSMASDVWMFGVCMWEIFSLGVKPWAGVTNSDVIMHIE-QG 584

  Fly   346 ERLHQPDACPPDVYAMM-LQCWDKTPAERPT 375
            .|...|:.||..:|..: .:.|...|.:|||
Worm   585 SRPPCPEKCPTALYNFIRSKMWAIEPHKRPT 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack	NP_647859.1	SAM_TNK-like	14..75	CDD:188938	13/75 (17%)
		PTKc_Ack_like	128..385	CDD:270636	94/249 (38%)
		UBA_TNK1	1031..1070	CDD:270513
kin-32	NP_740841.1	B41	5..230	CDD:214604	7/27 (26%)
		FERM_C_FAK1	226..336	CDD:270011	18/111 (16%)
		PKc_like	360..631	CDD:304357	96/261 (37%)
		STYKc	367..623	CDD:214568	96/254 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910