Protein Alignment Ack and Ack-like

DIOPT Version :10

• Sequence 1: NP_647859.1
• Gene: Ack / 38489
• FlyBaseID: FBgn0028484
• Length: 1073
• Species: Drosophila melanogaster
• Sequence 2: XP_061505911.1
• Gene: Ack-like / 1269516
• VectorBaseID: AGAMI1_009429
• Length: 1541
• Species: Anopheles gambiae
• Alignment Length: 1343
• Identity: 320/1343 - (23%)
• Similarity: 506/1343 - (37%)
• Gaps: 360/1343 - (26%)

  Fly    18 LEDLLREVQLEQFLDRIRDDLQVTRLAHFDYVLPDDLER-CGLGKPAIRRLMEAVRKKKAHQWRK 81
            |.:.|.|.:|:|:.:.::::|::|.:.|..|...:||.: .||.:|.||||.:...|...|.:..
Mosquito    15 LYEFLAEAELQQYYNSLKNELKITNVTHLKYATDEDLRQVSGLSRPEIRRLRKYYEKYYPHGYLN 79

  Fly    82 NILSKLIGGGKQPSSKKQSSAARE--------SSQGNGTQLTCLIHEKDITMGLKLGDGSFGVVR 138
            .|...|....|..::....:::.|        |...|...   :|....|.:..:||.|.||:|:
Mosquito    80 KIRRLLQTPRKDENNPNSPTSSVEPIKACPSPSKIPNNKH---IIPPDAICVNKQLGTGEFGIVQ 141

  Fly   139 RGEWSASPAGKVIPVAVKVLKSDNLTQPGIIDDFFREVQAMHALDHANLVRLYGVVL-SQPMMMI 202
            :|.|  :...:.|.||:|.|..:.:....:  :|.:|...||:::|.|:|||||||| ::.:|::
Mosquito   142 QGVW--TNGSERIQVAIKCLCRERMQSNPM--EFLKEAAMMHSIEHENIVRLYGVVLDTESLMLV 202

  Fly   203 TELAERGSLLDTLRKQ-CRHTSLTI--IWNWSVQIVTGMAYLEQKRFLHRDLACRNVLLAAGNKI 264
            ||||...|||:.|:.. .|.:.||:  :..::.||..||.|||.|||:|||||.||:|:.:.||:
Mosquito   203 TELAHLRSLLECLKDPGLRVSFLTVPTLCEFASQICNGMMYLENKRFIHRDLAARNILVFSKNKV 267

  Fly   265 KIGDFGLMRALPQEDDCYV--MSEHKKVPFPWCAPESLRFRQFSHASDTWMFGVTLWEMFSFGED 327
            ||.||||.|||....|.|.  .:.:.|:|..|||||.:.|.:|:||||.|.|||.|||:||:|..
Mosquito   268 KISDFGLSRALGVGKDYYQTNFNVNLKLPIAWCAPECINFLRFTHASDVWAFGVCLWEIFSYGFQ 332

  Fly   328 PWVGLNGSQILRKIDR-EGERLHQPDACPPDVYAMMLQCWDKTPAERPTFAALKEYLASMSPPVM 391
            ||..|.|.|||..||. ..:||.:|:.||.:.||:||:||....|:||.|:.:...|..:.|..:
Mosquito   333 PWAALTGHQILEAIDEPHYQRLEKPECCPKEYYALMLKCWQHDAAKRPKFSDIFLMLPDIKPEQL 397

  Fly   392 R--ASRSHHESKGLQIEPGDTIAIIDGRHELKLIKG----------------------------- 425
            :  .:.|.|:...|....|:.|.::|..:.....||
Mosquito   398 KTIVAYSEHKKDYLMYRQGEIITVLDKNNNAPYWKGVLNSGKTGLFNPANTVAYLDSLPSSVNRD 462

  Fly   426 ----------------------QN--QRTFDIGI------------FPRNL-------------L 441
                                  ||  :.|..:||            .|:||             |
Mosquito   463 SFCRTAERSSKRKIRTDMISRPQNDLKHTGHVGIDGVSFGDVAFLSSPQNLPRQIVTPYKPSEDL 527

  Fly   442 EQRKV---------------------------------------------GAAGDVVMRSSVGNG 461
            ||..:                                             |.|..||      :|
Mosquito   528 EQTPLLLPPTPTSPDSIQTASGYFSETLQLAGHQSFINAGENHHHIIDHGGTASTVV------DG 586

  Fly   462 SSSSPFGFCWGG---AAAMANGDDRQRKCASMTNQPHAKERKSTSSK----QFAYNKLVNDS-AT 518
            .::|.|.|...|   :....|.||.....|:..|...|     |||:    |..|:::.:|. ||
Mosquito   587 LTTSAFDFRNSGFKDSNPFINADDNGDNAAAYNNTAVA-----TSSRDGQNQHEYHEISDDDIAT 646

  Fly   519 G----------------LQRRNAVKHKGVVVGPQRPPPPQFQQEGILIDISPDM----RPIAEAG 563
            .                .:..:.:..:||   |..|..........|.::|..|    .....||
Mosquito   647 EKVFDQGPSLMDEMEHVFKSMSTISEQGV---PLSPDAENTNMRNELAELSSKMSRKTSSSTSAG 708

  Fly   564 TGGAKGA----GDSSSLQADS--SFCILDAPIDVPTYAGSSGSGDL-------NVSP-------- 607
            |.|:||:    ..:|:::..|  ...:|:..|::.....:....||       .:||
Mosquito   709 TLGSKGSKAKPKKASTVKPISMKDEKLLNQVIEMANEISAKSMTDLVTDANHQTLSPKRKFSFRF 773

  Fly   608 ------------------TYYNEQPQFDFDPAKMTASPGR-LQPPPY-------QMPPTYSNTM- 645
                              :....||......|..::..|| ||...:       |..|..|||:
Mosquito   774 PHIHNVVGGDGLRGSSNSSIAGNQPHVSGLSAGSSSHAGRGLQDKDHGILSGAGQHHPHSSNTLT 838

  Fly   646 -EFVQKRDLHQQQLATPVRERDPFDT-----TNVETTVALYSN------------------FNQS 686
             .:.:||:..|:....|..:|....|     .|.:..:.|:..                  ||.:
Mosquito   839 NSYREKRNFSQEVNNVPDLQRYRSLTGIENCQNNDIRIPLFDKESSDFCFKKSRELLSKQPFNMT 903

  Fly   687 LEAASPPAPIYNSPSVRK---SLFGGSKSNKENIPALESAAMQLNLSNL----TLERHDAT---- 740
            .:.:|..|.:..|.::.|   .|.|      ||:..:|.....|||..|    .||:.|:.
Mosquito   904 TDLSSVTAKLNGSKTLDKKTRDLIG------ENLLDIEKTLNALNLDFLQTYHELEKADSAETLF 962

  Fly   741 --CIQPV----EPVPAPPGDGVLLDKSFIAELEKDMYSNGQ-NRAQEEYQRNSTQMYASKDMVYK 798
              |...:    .|....|..|.|:..|.|..      ||.: |.|..|...:.:.....|
Mosquito   963 VECYSSMMCSSSPFQKSPPSGSLIRNSSIES------SNSRVNCALSEKGSSGSSSVTGK----- 1016

  Fly   799 QNLTPLK---NGAAPGSVHS-----------NHSSPSSTASPKQNN-----------VEAAAAAA 838
               :|..   .|:|.|:|.:           |.:||........||           .:|.....
Mosquito  1017 ---SPPSIGLGGSAAGNVPTSGGVSRCFSELNGTSPKPVMQQDHNNKYGIRDFKFRSFDARPKER 1078

  Fly   839 ATTQSVVNRIWYEQVASTQSEYYAQPPTEQAEEQIYQNHRHQQQQQQELNHSFVAISNRVVAP-- 901
            :...::.|....|.....||:........|....:    ..:|||.|::|..:...:..:...
Mosquito  1079 SDYYNIKNEYLSELTRKQQSQVLGSASVLQQTGAV----GSKQQQSQKINQLYQIYNTPMQGRKY 1139

  Fly   902 KNNAYSSTASLYDAVAASTAGST-YYGQVP----NGSGAVLYDEVTQDDYLRPTRPAPLAPPPLS 961
            |:::.|.||....||...:...| .|...|    |.||.::   .||.:      ..|..||.|:
Mosquito  1140 KDSSASITAPSSSAVRQRSLSFTENYELKPSLTSNKSGTIV---KTQSE------SQPSVPPLLT 1195

  Fly   962 AQQ--IQRRMEKMRLQQQQQLDGAHQLYAPVPSDYGREQEKLQQLMQELGSSAVEQDVRNALRAA 1024
            ..:  |..:...:|.:..::|.     |.|:............:|.:.|..|  |.|:|..|...
Mosquito  1196 TARNVITYKPRSIRARNLRRLS-----YNPINMVDSSSSSSESELDRNLAHS--ECDIRTRLHTT 1253

  Fly  1025 SGDVGLATRHYKIDQLARLGVAGRPQCEQALQQTNWSLEVAAE 1067
                  |||..:...:.|...:.....:..|..:|.|::.|.:
Mosquito  1254 ------ATRRRRHHYMTRKSNSNSASSQDKLYGSNASIKSAPQ 1290

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ack	NP_647859.1	SAM_TNK-like	14..75	CDD:188938	19/57 (33%)
		PTKc_Ack_like	128..385	CDD:270636	118/263 (45%)
		UBA_TNK1	1031..1070	CDD:270513	8/37 (22%)
Ack-like	XP_061505911.1	None