DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ack and TNK2

DIOPT Version :9

Sequence 1:NP_647859.1 Gene:Ack / 38489 FlyBaseID:FBgn0028484 Length:1073 Species:Drosophila melanogaster
Sequence 2:XP_011510619.1 Gene:TNK2 / 10188 HGNCID:19297 Length:1219 Species:Homo sapiens


Alignment Length:1194 Identity:396/1194 - (33%)
Similarity:539/1194 - (45%) Gaps:289/1194 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 TAWLEDLLREVQLEQFLDRIRDDLQVTRLAHFDYVLPDDLERCGLGKPAIRRLMEAVRKKKAHQW 79
            |.||.:||.||||:|:..|:||||.||||:||:||..:|||:.|:|:|..|||.|||:::||...
Human   171 TGWLLELLSEVQLQQYFLRLRDDLNVTRLSHFEYVKNEDLEKIGMGRPGQRRLWEAVKRRKALCK 235

  Fly    80 RKNILSKLIGGGK---------QPSSKKQSSAARESSQGNG--TQLTCLIHEKDITMGLKLGDGS 133
            ||:.:||:..|.:         ..|:.:::|.|.....|.|  ..|||||.|||:.:..||||||
Human   236 RKSWMSKVFSGKRLEAEFPPHHSQSTFRKTSPAPGGPAGEGPLQSLTCLIGEKDLRLLEKLGDGS 300

  Fly   134 FGVVRRGEWSASPAGKVIPVAVKVLKSDNLTQPGIIDDFFREVQAMHALDHANLVRLYGVVLSQP 198
            |||||||||.| |:||.:.||||.||.|.|:||..:|||.|||.|||:|||.||:|||||||:.|
Human   301 FGVVRRGEWDA-PSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPP 364

  Fly   199 MMMITELAERGSLLDTLRKQCRHTSLTIIWNWSVQIVTGMAYLEQKRFLHRDLACRNVLLAAGNK 263
            |.|:||||..|||||.|||...|..|..:..::||:..||.|||.|||:|||||.||:|||..:.
Human   365 MKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDL 429

  Fly   264 IKIGDFGLMRALPQEDDCYVMSEHKKVPFPWCAPESLRFRQFSHASDTWMFGVTLWEMFSFGEDP 328
            :|||||||||||||.||.|||.||:||||.|||||||:.|.||||||||||||||||||::|::|
Human   430 VKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEP 494

  Fly   329 WVGLNGSQILRKIDREGERLHQPDACPPDVYAMMLQCWDKTPAERPTFAALKEYLASMSPPVMRA 393
            |:||||||||.|||:|||||.:|:.||.|:|.:|:|||...|.:||||.||:::|....|..|||
Human   495 WIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRA 559

  Fly   394 SRSHHESKGLQIEPGDTIAIIDGRHELKLIKGQNQRTFDIGIFPRNLLEQRKVGAAGDV---VMR 455
            .:...|...|.|:..|.|.:|:||.|....:|||.||..:|.||||::......:|.|:   :..
Human   560 LQDFEEPDKLHIQMNDVITVIEGRAENYWWRGQNTRTLCVGPFPRNVVTSVAGLSAQDISQPLQN 624

  Fly   456 SSVGNGSSSSPFGFCWGGAAAMANGDDR--QRKCASMTNQPHAKERKSTSSKQFAYNKLVNDSAT 518
            |.:..|...|....|||       ..||  :....:..:.|.....:.::|:.            
Human   625 SFIHTGHGDSDPRHCWG-------FPDRIDELYLGNPMDPPDLLSVELSTSRP------------ 670

  Fly   519 GLQRRNAVKHKGVVVGPQRPPPPQFQQEGILIDISPDMRPIAEAGTGGAKGAGDSSSLQADSSFC 583
             .|....||.:    .|.|||.|.|..:      .|...|::|          |...|.:|....
Human   671 -PQHLGGVKRE----PPPRPPQPAFFTQ------KPTYDPVSE----------DQDPLSSDFKRL 714

  Fly   584 ILDAP------------IDVPTYAGSSGSGDLNVSPTYYNEQP-------------QFDFDPAKM 623
            .|..|            ..||....|.||| ..|:...:.|:|             |...|...:
Human   715 GLRKPGLPRGLWLAKPSARVPGTKASRGSG-AEVTLIDFGEEPVVPALRPCAPSLAQLAMDACSL 778

  Fly   624 -----TASPGRLQPPPYQMPPTYSNTMEFVQKRDLHQQQLATP------VRERDPFDTTNVETTV 677
                 ..||.|..|.|....|..          |...:.|..|      .::.|.|:..::.:|:
Human   779 LDETPPQSPTRALPRPLHPTPVV----------DWDARPLPPPPAYDDVAQDEDDFEICSINSTL 833

  Fly   678 A----------LYSNFNQSLEAASPPAPIYNSPSVRKSLF----GGSK-----SNKENIPALESA 723
            .          ..:|:....|.|.||.|:      ..:||    ||.|     ...|...||:..
Human   834 VGAGVPAGPSQGQTNYAFVPEQARPPPPL------EDNLFLPPQGGGKPPSSAQTAEIFQALQQE 892

  Fly   724 AM-QLN------LSNLTLERHDATCIQPVEPV------------PAPPGDGVLLDKSFIAELEKD 769
            .| ||.      ..:.:....|...:.|..|:            |||||:            |:.
Human   893 CMRQLQAPAGSPAPSPSPGGDDKPQVPPRVPIPPRPTRPHVQLSPAPPGE------------EET 945

  Fly   770 MYSNGQNRAQEEYQRNSTQMYASKDMVYKQNLTPLKNGAAPGSVHSNHSSPSSTASPKQNNVEAA 834
            ....|.........|.......|:      ..:||   ..||   |:...|..::||        
Human   946 SQWPGPASPPRVPPREPLSPQGSR------TPSPL---VPPG---SSPLPPRLSSSP-------- 990

  Fly   835 AAAAATTQSVVNRIWY------------------------EQVASTQSEYYAQPPTEQAEEQIYQ 875
            .....||||..:...|                        ::|:||  .||..|......|: ||
Human   991 GKTMPTTQSFASDPKYATPQVIQAPGPRAGPCILPIVRDGKKVSST--HYYLLPERPSYLER-YQ 1052

  Fly   876 NHRHQQQQQQELNHSFVAISNRVVAPKNNAYSSTASLYDAVAASTAGSTYYGQVPNGSGAVLYDE 940
            ....:.|..:|.....|.:   ::.|.:.         .|.||.||                   
Human  1053 RFLREAQSPEEPTPLPVPL---LLPPPST---------PAPAAPTA------------------- 1086

  Fly   941 VTQDDYLRPTRPAPLA-------------------PPPLSAQQIQRRMEKMRLQQQQQLDGAHQL 986
                    ..||.|.|                   |||.:..::.:|                  
Human  1087 --------TVRPMPQAALDPKANFSTNNSNPGARPPPPRATARLPQR------------------ 1125

  Fly   987 YAPVPSD---YGREQEKLQQLMQELGSSAVEQDVRNALRAASGDVGLATRHYKIDQLARLGVAGR 1048
              ..|.|   .||..:|: |::|.:......::.:.||:.....|..|.::.|::||..||:..|
Human  1126 --GCPGDGPEAGRPADKI-QMLQAMVHGVTTEECQAALQCHGWSVQRAAQYLKVEQLFGLGLRPR 1187

  Fly  1049 PQCEQALQQTNWSLEVAAELLLNA 1072
            .:|.:.|:..:|:||.|...||.:
Human  1188 GECHKVLEMFDWNLEQAGCHLLGS 1211

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AckNP_647859.1 SAM_TNK-like 14..75 CDD:188938 35/59 (59%)
PTKc_Ack_like 128..385 CDD:270636 173/256 (68%)
UBA_TNK1 1031..1070 CDD:270513 13/38 (34%)
TNK2XP_011510619.1 SAM_TNK-like 170..231 CDD:188938 35/59 (59%)
STYKc 290..549 CDD:214568 172/259 (66%)
PTKc_Ack_like 294..551 CDD:270636 173/257 (67%)
SH3_9 559..608 CDD:291278 20/48 (42%)
GTPase_binding 611..678 CDD:286160 13/86 (15%)
Inhibitor_Mig-6 953..1017 CDD:288414 15/83 (18%)
UBA_ACK1 1140..1183 CDD:270460 10/43 (23%)
UBA_TNK1 1170..1209 CDD:270513 13/38 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165151987
Domainoid 1 1.000 368 1.000 Domainoid score I921
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 545 1.000 Inparanoid score I1170
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1008736at2759
OrthoFinder 1 1.000 - - FOG0002936
OrthoInspector 1 1.000 - - oto91204
orthoMCL 1 0.900 - - OOG6_106253
Panther 1 1.100 - - LDO PTHR24418
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R7181
SonicParanoid 1 1.000 - - X3854
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1211.930

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