DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ack and tnk2l

DIOPT Version :9

Sequence 1:	NP_647859.1	Gene:	Ack / 38489	FlyBaseID:	FBgn0028484	Length:	1073	Species:	Drosophila melanogaster
Sequence 2:	XP_031755475.1	Gene:	tnk2l / 101732042	XenbaseID:	XB-GENE-22064896	Length:	681	Species:	Xenopus tropicalis

Alignment Length:	693	Identity:	251/693 - (36%)
Similarity:	357/693 - (51%)	Gaps:	142/693 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LGSE--TAWLEDLLREVQLEQFLDRIRDDLQVTRLAHFDYVLPDDLERCGLGKPAIRRLMEAVRK 73
            :|:|  |.||..||||||||||..::||.|.:||..|||:|.|.||::.|:|:|..|||.||:|:
Frog     1 MGTEEGTDWLLALLREVQLEQFYSKLRDGLNITRPGHFDFVKPFDLDQIGMGRPGQRRLFEALRR 65

  Fly    74 KKAHQWRKNILSKLIGGGKQPSSKKQSSAARESSQGN------GTQLTCLIHEKDITMGLKLGDG 132
            :|.....|:.:.|:.     ||...:|....:|.:.:      .:.:.|||:|:|:::..:||||
Frog    66 RKPPVRPKSWMYKVF-----PSKNPESPEGPQSPEVSPLRMEPDSSMKCLINERDLSLFERLGDG 125

  Fly   133 SFGVVRRGEWSASPAGKVIPVAVKVLKSDNLTQPGIIDDFFREVQAMHALDHANLVRLYGVVLSQ 197
            .|||||||||..| :|:.:.||||.|:||..:.|..:.||.:||.:|:.|||.:|:||||||||:
Frog   126 CFGVVRRGEWRVS-SGRSVNVAVKYLRSDACSDPEALQDFLQEVNSMYVLDHPHLIRLYGVVLSK 189

  Fly   198 PMMMITELAERGSLLDTLRK---QCRHTSLTIIWNWSVQIVTGMAYLEQKRFLHRDLACRNVLLA 259
            |:.|:||:|..|||||.|..   .|...||.::|.:|:||.:||.|||..:|:|||||.|||||.
Frog   190 PLKMVTEIAPLGSLLDALHNSYGSCGSFSLPLLWKYSLQIASGMKYLESYKFIHRDLATRNVLLT 254

  Fly   260 AGNKIKIGDFGLMRALPQEDDCYVMSEHKKVPFPWCAPESLRFRQFSHASDTWMFGVTLWEMFSF 324
            :.:..|||||||||||....|.|:||.|:|:||.||.||||:...||:.||.|||||||||||::
Frog   255 SEDVAKIGDFGLMRALGGHSDHYIMSTHRKIPFAWCPPESLKIGAFSNQSDVWMFGVTLWEMFTY 319

  Fly   325 GEDPWVGLNGSQILRKIDREGERLHQPDACPPDVYAMMLQCWDKTPAERPTFAALKEYLASMSPP 389
            |::||:|.:|.|||.||||:.|.|.:||.||..:|.:|.:||...|.:|||||.|...|::..|.
Frog   320 GQEPWMGFSGKQILLKIDRDRETLERPDDCPQALYEVMKKCWIYEPDQRPTFANLMGLLSAARPQ 384

  Fly   390 VMRASRSHHESKGLQIEPGDTIAIIDGRHELKLIKGQNQRTFDIGIFPRNLLEQRKVGAAGDVVM 454
            .:|..|..::...||:|.||.:.:|:...::.|.:|||:||..:|.||.:::..|.:
Frog   385 EVRIQRDFNDPSCLQLESGDVVTVIEAGSDMPLWRGQNKRTLKVGRFPASIVVTRDL-------- 441

  Fly   455 RSSVGNGSSSSPFGFCWGGAAAMANGDDRQRKCASMTNQPHAKERKSTSSKQF--AYNKLVNDSA 517
                                                 .|.....|:|||..|.  ...:..||
Frog   442 -------------------------------------PQFQVSGRQSTSLMQLPGIEGESEND-- 467

  Fly   518 TGLQRRNAVKHKG------VVVGPQRPPPPQFQQEGILIDISPDMRPIAEAGTGGAKGAGDSSSL 576
                |||.:|.||      .::|.||                                  .|.||
Frog   468 ----RRNRIKDKGRKADRSNLLGMQR----------------------------------ISKSL 494

  Fly   577 QADSSFCILDAPIDVPTYAGSSGSGDLNVSPTYYNEQPQFDFDPAKMTASPGR------------ 629
            ::.|..|:   |.:.......:.:.||...||               .|||.|
Frog   495 ESISEPCV---PANRQQPPMRNRAHDLESHPT---------------NASPRRISDIPQIRNFAI 541

  Fly   630 LQPPPYQMPPTYSNTMEFV--QKRDLHQQQLATPVRERDPFDT 670
            ::||.:..|...::...|:  ...|...|.:...|..:.|..|
Frog   542 MRPPVFPKPKRPASKERFIPSPNADFPAQSVGGGVPRQSPGGT 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack	NP_647859.1	SAM_TNK-like	14..75	CDD:188938	35/62 (56%)
		PTKc_Ack_like	128..385	CDD:270636	144/259 (56%)
		UBA_TNK1	1031..1070	CDD:270513
tnk2l	XP_031755475.1	SAM_TNK-like	6..67	CDD:188938	34/60 (57%)
		PKc_like	120..380	CDD:419665	144/260 (55%)
		SH3	385..436	CDD:418401	17/50 (34%)
		UBA_like_SF	606..649	CDD:419673
		UBA_like_SF	636..675	CDD:419673
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1008736at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010