DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fit1 and FERMT3

DIOPT Version :9

Sequence 1:	NP_647858.2	Gene:	Fit1 / 38488	FlyBaseID:	FBgn0035498	Length:	708	Species:	Drosophila melanogaster
Sequence 2:	NP_001369291.1	Gene:	FERMT3 / 83706	HGNCID:	23151	Length:	667	Species:	Homo sapiens

Alignment Length:	724	Identity:	290/724 - (40%)
Similarity:	433/724 - (59%)	Gaps:	96/724 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ENTWNLRILI--TDLQVEK-TLRVKGDQHIGGVMLNLVDP-ELPKDWSDHALWWPAKNIWLTRTR 66
            :::|.||:.:  .|.:.|. ||||.|:.|||||:|.:|:. ...:||||||:||..|..||.:|.
Human    13 DSSWELRVFVGEEDPEAESVTLRVTGESHIGGVLLKIVEQINRKQDWSDHAIWWEQKRQWLLQTH 77

  Fly    67 STLDQAGVQSDSFLHFTPMHKTLRVQMPDLRYLDYRVNFSAKTFGAVVSLCKDLDIRYPEELSFC 131
            .|||:.|:.:|:.|.|.|.|:.:.:::|:.|.|..|.:||...|.||.::|:.|.||:|||||..
Human    78 WTLDKYGILADARLFFGPQHRPVILRLPNRRALRLRASFSQPLFQAVAAICRLLSIRHPEELSLL 142

  Fly   132 KPLEPEHLKKNFSKLPQRKI----PVAEANGIAYVQPALDTNSFVPITGAYNGSNGSLDRSHNGN 192
            :..|.:..||. .|.|:.::    .|..|.|:|   |||
Human   143 RAPEKKEKKKK-EKEPEEELYDLSKVVLAGGVA---PAL-------------------------- 177

  Fly   193 LLCAPASPYTRRAATAPGTPISSPTGTWKHNSTGYASYDSNSSFGDLQENLAMSPR-SPSPDVRA 256
                                           ..|..::.|:|:..:...::...|: .|.|.:..
Human   178 -------------------------------FRGMPAHFSDSAQTEACYHMLSRPQPPPDPLLLQ 211

  Fly   257 RLVRPKSRVEKARLNVGWLDSSLSIMEQGVREYDTLCLRFKYFTFFDLNPKYDQVRINQLYEQAK 321
            ||.||.|..:|.:|:..|||||..:|:||::..|.|.|||||::||||:||.|.||:.||||||:
Human   212 RLPRPSSLSDKTQLHSRWLDSSRCLMQQGIKAGDALWLRFKYYSFFDLDPKTDPVRLTQLYEQAR 276

  Fly   322 WSILNEELEPTEEETLMFAALQFQVNHQTDLHPPGIDSGIDTSSQETGGEDDIDSALNELQITLE 386
            |.:|.||::.||||.::|||||:.:|..:.....|..:|.|.      |.||:|.||:.|::.||
Human   277 WDLLLEEIDCTEEEMMVFAALQYHINKLSQSGEVGEPAGTDP------GLDDLDVALSNLEVKLE 335

  Fly   387 GPGGGKDQGNITRIPELSDYLKFL----KPQRFTLKGYKRYFFTYRDLHLHLYKSQDESRRGAPT 447
            |........::|.||||.|:|:..    :|::.|||||::::..:::..|..||||||: .|.|.
Human   336 GSAPTDVLDSLTTIPELKDHLRIFRIPRRPRKLTLKGYRQHWVVFKETTLSYYKSQDEA-PGDPI 399

  Fly   448 ISINLKGCEVTPDVNLAQGKFAIRLEVPSEIRNGPN--SEVWVRCDNEEQYAKWMAACRLAAKGR 510
            ..:|||||||.||||::..||.|:|.|||     |.  ||:::||.:|:|||:|||.||||:|||
Human   400 QQLNLKGCEVVPDVNVSGQKFCIKLLVPS-----PEGMSEIYLRCQDEQQYARWMAGCRLASKGR 459

  Fly   511 SLADSSYDSEVSSIRSLLQMQKPAQGAP------LTVNPRSVEPMDYLSPKMMRKLSSKAV-QRI 568
            ::|||||.|||.:|.:.|.:|:...|.|      ...:...:.|...::|:..||..:|.: .||
Human   460 TMADSSYTSEVQAILAFLSLQRTGSGGPGNHPHGPDASAEGLNPYGLVAPRFQRKFKAKQLTPRI 524

  Fly   569 LEAHANVRQLSLMDAKMKYIQAWQSLPDFGVTLFIIKFDGHKKEELLGVANNRIMRMDLNTGDHI 633
            ||||.||.||||.:|::::|||||||||||::..:::|.|.:|:|:||:||||::|:||..||.:
Human   525 LEAHQNVAQLSLAEAQLRFIQAWQSLPDFGISYVMVRFKGSRKDEILGIANNRLIRIDLAVGDVV 589

  Fly   634 KTWRYNTMKAWNVNWGIKCMMIQLQDE-NIVFSVQSADCKVVHEFIGGYIFMSMRSKENNQTLNE 697
            ||||::.|:.|||||.|:.:.|:..:. |:.||..||.|::|||:||||||:|.|.:...:.|:|
Human   590 KTWRFSNMRQWNVNWDIRQVAIEFDEHINVAFSCVSASCRIVHEYIGGYIFLSTRERARGEELDE 654

  Fly   698 EMFHKLTGG 706
            ::|.:||||
Human   655 DLFLQLTGG 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fit1	NP_647858.2	FERM_B-lobe	305..>348	CDD:298919	24/42 (57%)
		PH_fermitin	401..529	CDD:269943	66/133 (50%)
		PH	401..508	CDD:278594	54/112 (48%)
		FERM_M	<538..602	CDD:278785	30/70 (43%)
		FERM_C_fermitin	596..686	CDD:270026	45/90 (50%)
FERMT3	NP_001369291.1	FERM_F0_KIND3	15..97	CDD:340702	37/81 (46%)
		FERM_F1_KIND3	98..254	CDD:340705	57/216 (26%)
		B41	<218..>315	CDD:214604	48/96 (50%)
		PH_fermitin	350..478	CDD:269943	66/133 (50%)
		FERM_M	<467..557	CDD:395297	37/89 (42%)
		FERM_C_fermitin	552..643	CDD:270026	45/90 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156366
Domainoid	1	1.000	298	1.000	Domainoid score	I1454
eggNOG	1	0.900	-	-		E1_KOG3727
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	636	1.000	Inparanoid score	I828
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132272at33208
OrthoFinder	1	1.000	-	-		FOG0001455
OrthoInspector	1	1.000	-	-		mtm8583
orthoMCL	1	0.900	-	-		OOG6_103097
Panther	1	1.100	-	-	O	PTHR16160
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X911
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.760