DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Fit1 and FERMT1

DIOPT Version :9

Sequence 1:NP_647858.2 Gene:Fit1 / 38488 FlyBaseID:FBgn0035498 Length:708 Species:Drosophila melanogaster
Sequence 2:NP_060141.3 Gene:FERMT1 / 55612 HGNCID:15889 Length:677 Species:Homo sapiens


Alignment Length:725 Identity:316/725 - (43%)
Similarity:460/725 - (63%) Gaps:86/725 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 TWNLRILI----TDLQVEKTLRVKGDQHIGGVMLNLVDP-ELPKDWSDHALWWPAKNIWLTRTRS 67
            :|.|.:.:    .:.|.:.||||.||.|:|||||.||:. .:.:||||.||||..|:.||.:|..
Human    11 SWELVVRVDHPNEEQQKDVTLRVSGDLHVGGVMLKLVEQINISQDWSDFALWWEQKHCWLLKTHW 75

  Fly    68 TLDQAGVQSDSFLHFTPMHKTLRVQMPDLRYLDYRVNFSAKTFGAVVSLCKDLDIRYPEELSFCK 132
            |||:.|||:|:.|.|||.||.||:::|:|:.:..||:|||..|.||..:||.|:||..||||..|
Human    76 TLDKYGVQADAKLLFTPQHKMLRLRLPNLKMVRLRVSFSAVVFKAVSDICKILNIRRSEELSLLK 140

  Fly   133 PLEPEHLKKNFSKLPQRKIPVAE----------ANGIAYVQPALDTNSFVPITGAYNGSNGSLDR 187
            | ..::.||...|....|.|:.|          |:| :.|.|.|.:.:..||....|        
Human   141 P-SGDYFKKKKKKDKNNKEPIIEDILNLESSPTASG-SSVSPGLYSKTMTPIYDPIN-------- 195

  Fly   188 SHNGNLLCAPASPYTRRAATAPGTPISSPTGTWKHNSTGYASYDSNSSFGDLQENLAMSPRSPSP 252
                                  |||.|| |.||..:|   ...:.|.|.      ||.|....||
Human   196 ----------------------GTPASS-TMTWFSDS---PLTEQNCSI------LAFSQPPQSP 228

  Fly   253 DVRARLVRPKSRVEKARLNVGWLDSSLSIMEQGVREYDTLCLRFKYFTFFDLNPKYDQVRINQLY 317
            :..|.:.:|:|.|:||:||.||||||.|:||||::|.:.|.|||||::|||||||||.|||||||
Human   229 EALADMYQPRSLVDKAKLNAGWLDSSRSLMEQGIQEDEQLLLRFKYYSFFDLNPKYDAVRINQLY 293

  Fly   318 EQAKWSILNEELEPTEEETLMFAALQFQVNHQTDLHPPGIDSGIDTSSQETGGE---DDIDSALN 379
            |||:|:||.||::.||||.|:|||||:.::..:          :...:|:..||   |:|::||:
Human   294 EQARWAILLEEIDCTEEEMLIFAALQYHISKLS----------LSAETQDFAGESEVDEIEAALS 348

  Fly   380 ELQITLEGPGGGKDQGNITRIPELSDYLKFLKPQRFTLKGYKRYFFTYRDLHLHLYKSQDESRRG 444
            .|::||||........:||.||:|:|.||..:|::...|.:|:|:|.::|..:..:|:: |..:|
Human   349 NLEVTLEGGKADSLLEDITDIPKLADNLKLFRPKKLLPKAFKQYWFIFKDTSIAYFKNK-ELEQG 412

  Fly   445 APTISINLKGCEVTPDVNLAQGKFAIRLEVPSEIRNGPNSEVWVRCDNEEQYAKWMAACRLAAKG 509
            .|...:||:||||.||||:|..||.|:|.:|  :.:|.| |:::|||:|.|||:|||||.||:||
Human   413 EPLEKLNLRGCEVVPDVNVAGRKFGIKLLIP--VADGMN-EMYLRCDHENQYAQWMAACMLASKG 474

  Fly   510 RSLADSSYDSEVSSIRSLLQMQKPAQGAPLTVNPRSVEPMD-----YLSPKMMRKLSSKAV-QRI 568
            :::|||||..||.:|.|.|:|:.....:.:.   .|:|.||     ::||:..::..||.: .||
Human   475 KTMADSSYQPEVLNILSFLRMKNRNSASQVA---SSLENMDMNPECFVSPRCAKRHKSKQLAARI 536

  Fly   569 LEAHANVRQLSLMDAKMKYIQAWQSLPDFGVTLFIIKFDGHKKEELLGVANNRIMRMDLNTGDHI 633
            ||||.||.|:.|::||:::||||||||:||:|.::::|.|.||:::|||:.||::::|..||..:
Human   537 LEAHQNVAQMPLVEAKLRFIQAWQSLPEFGLTYYLVRFKGSKKDDILGVSYNRLIKIDAATGIPV 601

  Fly   634 KTWRYNTMKAWNVNWGIKCMMIQLQDENI--VFSVQSADCKVVHEFIGGYIFMSMRSKENNQTLN 696
            .|||:..:|.|||||..:.::|:. |:|:  .|:..|||||:|||:||||||:|.|||:.|:||:
Human   602 TTWRFTNIKQWNVNWETRQVVIEF-DQNVFTAFTCLSADCKIVHEYIGGYIFLSTRSKDQNETLD 665

  Fly   697 EEMFHKLTGG 706
            |::|||||||
Human   666 EDLFHKLTGG 675

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fit1NP_647858.2 FERM_B-lobe 305..>348 CDD:298919 30/42 (71%)
PH_fermitin 401..529 CDD:269943 59/127 (46%)
PH 401..508 CDD:278594 48/106 (45%)
FERM_M <538..602 CDD:278785 31/69 (45%)
FERM_C_fermitin 596..686 CDD:270026 42/91 (46%)
FERMT1NP_060141.3 B41 <250..>343 CDD:214604 55/102 (54%)
PH_fermitin 370..493 CDD:269943 59/126 (47%)
FERM_M <514..570 CDD:306805 27/55 (49%)
FERM_C_fermitin 564..655 CDD:270026 42/91 (46%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165156364
Domainoid 1 1.000 298 1.000 Domainoid score I1454
eggNOG 1 0.900 - - E1_KOG3727
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 636 1.000 Inparanoid score I828
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG48345
OrthoDB 1 1.010 - - D132272at33208
OrthoFinder 1 1.000 - - FOG0001455
OrthoInspector 1 1.000 - - mtm8583
orthoMCL 1 0.900 - - OOG6_103097
Panther 1 1.100 - - LDO PTHR16160
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2884
SonicParanoid 1 1.000 - - X911
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.800

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