Protein Alignment Fit1 and fermt2

DIOPT Version :10

• Sequence 1: NP_647858.2
• Gene: Fit1 / 38488
• FlyBaseID: FBgn0035498
• Length: 708
• Species: Drosophila melanogaster
• Sequence 2: XP_005158972.1
• Gene: fermt2 / 553051
• ZFINID: ZDB-GENE-050506-132
• Length: 695
• Species: Danio rerio
• Alignment Length: 732
• Identity: 340/732 - (46%)
• Similarity: 479/732 - (65%)
• Gaps: 82/732 - (11%)

  Fly     6 ENTWNLRILITDLQVEKTLRVKGDQHIGGVMLNLVDP-ELPKDWSDHALWWPAKNIWLTRTRSTL 69
            :.||.|::.:|||..:.:|||.|:.|||||||.||:. ::.||||||||||..|..||.:|..||
Zfish    15 DGTWELKMHVTDLNRDVSLRVTGEIHIGGVMLKLVEKLDVKKDWSDHALWWEKKKTWLLKTHWTL 79

  Fly    70 DQAGVQSDSFLHFTPMHKTLRVQMPDLRYLDYRVNFSAKTFGAVVSLCKDLDIRYPEELSFC-KP 133
            |:.|:|:|:.|.|||.||.||:|:|:::::..:||||.:.|.||..:||..:||:|||||.. ||
Zfish    80 DKYGIQADARLLFTPQHKLLRLQLPNMKHMRVKVNFSDRVFKAVSDICKTFNIRHPEELSLLRKP 144

  Fly   134 LEPEHLKKNFSKLPQRKIPVAEANGIAYVQPALDTNS------FVPITGAYNGSNGSLDRSHNGN 192
            .:|:..||        |:..||...:....|.|...|      ..|:.|:...|.|...::
Zfish   145 RDPKKKKK--------KLEDAEEETLELEGPLLTPGSASDVLYIGPVKGSIYSSPGLYSKT---- 197

  Fly   193 LLCAPASPYTRRAATAPGTPISSPTGTWKHNSTGYASYDSNSSFGD--LQEN----LAMSPRSPS 251
                    .|....:..|:|: |||..|               |||  |.|.    ||:|....|
Zfish   198 --------MTPTYDSRDGSPL-SPTSAW---------------FGDSPLSEGNPSILAVSQPITS 238

  Fly   252 PDVRARLVRPKSRVEKARLNVGWLDSSLSIMEQGVREYDTLCLRFKYFTFFDLNPKYDQVRINQL 316
            ||:..::.:|:|.::||::|.||||||.|:|||.|:|.:.|.|||||.:|||||||||.:|:|||
Zfish   239 PDILVKMYKPQSLLDKAKINQGWLDSSRSLMEQDVKENEVLLLRFKYHSFFDLNPKYDAIRVNQL 303

  Fly   317 YEQAKWSILNEELEPTEEETLMFAALQFQVNHQTDLHPPGIDSGIDTSSQETGGEDDIDSALNEL 381
            ||||||:||.||:|.||||.:||||||:.:|   .|.....|:.::.|.:|.   |::|:||::|
Zfish   304 YEQAKWAILLEEIECTEEEMMMFAALQYHIN---KLSIMSSDNHMNNSEKEV---DEVDAALSDL 362

  Fly   382 QITLEGPGGGKDQGNITRIPELSDYLKFLKPQRFTLKGYKRYFFTYRDLHLHLYKSQDESRRGAP 446
            :|||||.......|:||.||||:||:|..||::.||||||:|:.|::|:.:..|||::|: .|.|
Zfish   363 EITLEGGKTSNTLGDITSIPELADYVKVFKPKKLTLKGYKQYWCTFKDITISCYKSREEA-HGTP 426

  Fly   447 TISINLKGCEVTPDVNLAQGKFAIRLEVPSEIRNGPNSEVWVRCDNEEQYAKWMAACRLAAKGRS 511
            ...:||:|||||||||::..||.|:|.:|  :.:|.| |:|:|||.|:|||:||||||||:||::
Zfish   427 AHQMNLRGCEVTPDVNISGQKFNIKLLIP--VADGMN-EIWLRCDTEKQYAQWMAACRLASKGKT 488

  Fly   512 LADSSYDSEVSSIRSLLQMQKPAQGAPLTVNPRSVEPMD-------YLSPKMMRKLSSK------ 563
            :|||||:.||.:|.|.|:||.      :..:|:.:||:.       .:||:.::|..:|
Zfish   489 MADSSYNLEVQNILSFLKMQH------MNPDPQIIEPITTDINPECLVSPRYLKKYKNKQPGFVR 547

  Fly   564 --AVQRILEAHANVRQLSLMDAKMKYIQAWQSLPDFGVTLFIIKFDGHKKEELLGVANNRIMRMD 626
              ...||||||.||.|:||::|||::||||||||:||:|.|:.||.|.||:||:|:..||::|||
Zfish   548 DLISARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFLAKFQGGKKDELIGITYNRLIRMD 612

  Fly   627 LNTGDHIKTWRYNTMKAWNVNWGIKCMMIQLQDE-NIVFSVQSADCKVVHEFIGGYIFMSMRSKE 690
            ..|||.|||||::.||.|||||.||.:.::..|| ::.|.....||||||||||||||:|.|:|:
Zfish   613 AGTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEPSLAFICAEVDCKVVHEFIGGYIFLSTRAKD 677

  Fly   691 NNQTLNEEMFHKLTGGW 707
            .|::|:||||:|||.||
Zfish   678 QNESLDEEMFYKLTSGW 694

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fit1	NP_647858.2	FERM_F0_kindlins	8..86	CDD:340615	43/78 (55%)
		FERM_F1_kindlins	87..299	CDD:340616	76/224 (34%)
		B41	<274..>363	CDD:214604	54/88 (61%)
		PH_fermitin	401..529	CDD:269943	69/127 (54%)
		FERM_M	<490..602	CDD:459788	60/126 (48%)
		FERM_C_fermitin	596..686	CDD:270026	51/90 (57%)
fermt2	XP_005158972.1	FERM_F0_KIND2	17..96	CDD:340701	43/78 (55%)
		FERM_F1_KIND2	97..286	CDD:340704	76/224 (34%)
		B41	<253..>333	CDD:214604	55/79 (70%)
		PH_fermitin	382..506	CDD:269943	69/127 (54%)
		FERM_M	<464..588	CDD:459788	62/129 (48%)
		PH-like	582..673	CDD:473070	51/90 (57%)