DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fit1 and fermt3

DIOPT Version :9

Sequence 1:	NP_647858.2	Gene:	Fit1 / 38488	FlyBaseID:	FBgn0035498	Length:	708	Species:	Drosophila melanogaster
Sequence 2:	XP_012816277.1	Gene:	fermt3 / 448215	XenbaseID:	XB-GENE-1013715	Length:	659	Species:	Xenopus tropicalis

Alignment Length:	708	Identity:	300/708 - (42%)
Similarity:	430/708 - (60%)	Gaps:	72/708 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ENTWNLRILITDLQVEK---TLRVKGDQHIGGVMLNLVDP-ELPKDWSDHALWWPAKNIWLTRTR 66
            :::|.|:|.:.|:..:.   |.||.|:.|||||:|..|:. .:.:||||||:||..|..||.:|.
Frog    13 DSSWELKIYVEDMGPDADPVTFRVTGETHIGGVILQAVEKIGISQDWSDHAIWWQQKCQWLLKTS 77

  Fly    67 STLDQAGVQSDSFLHFTPMHKTLRVQMPDLRYLDYRVNFSAKTFGAVVSLCKDLDIRYPEELSFC 131
            .|||:.||.:|:.|.||..||.:.:.:|:.|.|..||.||:.||.|...:||.|.|||||||||.
Frog    78 WTLDKYGVLADARLIFTSQHKPVILSLPNQRSLRIRVCFSSTTFSACAEVCKVLGIRYPEELSFL 142

  Fly   132 KPLEPEHLKKNFSKLPQRKIPVAEANGIAYVQPALDTNSFVPITGAYNGSNGSLDRSHNGNLLCA 196
            |..|.:..||      ::|.||        .|...|..|..|       |:||......|.:
Frog   143 KAPEDKEKKK------KKKDPV--------TQEIFDLTSLQP-------SDGSAVLLQQGGI--- 183

  Fly   197 PASPYTRRAATAPGTPISSPTGTWKHNSTGYASYDSNSSFGDLQENLAMSPRSPSPDVRARLVRP 261
                        |...::||..     ..||.:             |::...:.:|:...:..:|
Frog   184 ------------PAHFLASPEA-----QEGYRA-------------LSVCQTALTPEDIQKRYKP 218

  Fly   262 KSRVEKARLNVGWLDSSLSIMEQGVREYDTLCLRFKYFTFFDLNPKYDQVRINQLYEQAKWSILN 326
            .:..:|..::..||:||.|:|:|||:|.|.|.|.|||:||.||:||.|.||||.|:|||:|::|.
Frog   219 ITVTDKTLIHGRWLNSSKSLMQQGVQEGDRLWLHFKYYTFHDLDPKLDVVRINLLFEQARWAVLL 283

  Fly   327 EELEPTEEETLMFAALQFQVNHQTDLHPPGIDSGIDTSSQETGGEDDIDSALNELQITLEGPGGG 391
            ||.|.||||.::|||||:.||..:....| :|...|.:.|      |::.||:.|::.::.....
Frog   284 EETECTEEEMMVFAALQYHVNKLSVTSNP-MDLPQDPALQ------DLEEALSNLEVKMDANTPS 341

  Fly   392 KDQGNITRIPELSDYLKFLKPQRFTLKGYKRYFFTYRDLHLHLYKSQDESRRGAPTISINLKGCE 456
            :....|...|.|.:||:..:|::.||||||:.:...:|.:|..|||::|: ||.|.|...|||||
Frog   342 EALEGIQLEPGLQEYLRVFRPKKMTLKGYKQNWVLLKDTNLSCYKSKEET-RGEPLIMFGLKGCE 405

  Fly   457 VTPDVNLAQGKFAIRLEVPSEIRNGPNSEVWVRCDNEEQYAKWMAACRLAAKGRSLADSSYDSEV 521
            |.|:||::..||.|||.||:.  .|.| ||::|||:|:|||:|||.||||||||::.|:||:.||
Frog   406 VIPEVNISSQKFCIRLLVPTP--EGMN-EVYLRCDDEQQYARWMAGCRLAAKGRTMGDASYEGEV 467

  Fly   522 SSIRSLLQMQKPAQGAPLTVNPRSVEPMDYLSPKMMRKLSSKAV-QRILEAHANVRQLSLMDAKM 585
            .|:.|.|.:||.......|....|:.....:||:..:||..|.: .|||||:.|:.||||:|||.
Frog   468 QSVLSFLNLQKSTTTQSNTTASDSINVHALVSPRFQKKLKPKQLTPRILEAYQNIAQLSLIDAKQ 532

  Fly   586 KYIQAWQSLPDFGVTLFIIKFDGHKKEELLGVANNRIMRMDLNTGDHIKTWRYNTMKAWNVNWGI 650
            ::||||||||||||:.|:::|.|.:::|:||:|:||::|:||:.||.:|||.|:.||.|||||.|
Frog   533 RFIQAWQSLPDFGVSYFLVRFKGSRRDEILGIASNRLIRIDLSVGDIVKTWMYSNMKQWNVNWDI 597

  Fly   651 KCMMIQLQDE-NIVFSVQSADCKVVHEFIGGYIFMSMRSKE-NNQTLNEEMFHKLTGG 706
            :.:.|:..:. |:.|:..||.||||||:||||||||.|.|: .::|||||:|||||||
Frog   598 RQVSIEFTEHINVAFTCVSAPCKVVHEYIGGYIFMSTRGKDGGSKTLNEELFHKLTGG 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fit1	NP_647858.2	FERM_B-lobe	305..>348	CDD:298919	26/42 (62%)
		PH_fermitin	401..529	CDD:269943	66/127 (52%)
		PH	401..508	CDD:278594	55/106 (52%)
		FERM_M	<538..602	CDD:278785	32/64 (50%)
		FERM_C_fermitin	596..686	CDD:270026	48/90 (53%)
fermt3	XP_012816277.1	FERM_F0_KIND3	15..97	CDD:340702	36/81 (44%)
		FERM_F1_KIND3	98..256	CDD:340705	62/211 (29%)
		B41	<221..>303	CDD:214604	46/81 (57%)
		PH_fermitin	351..474	CDD:269943	66/126 (52%)
		FERM_M	<480..549	CDD:366056	32/68 (47%)
		FERM_C_fermitin	543..634	CDD:270026	48/90 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	296	1.000	Domainoid score	I1456
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	633	1.000	Inparanoid score	I827
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132272at33208
OrthoFinder	1	1.000	-	-		FOG0001455
OrthoInspector	1	1.000	-	-		mtm9477
Panther	1	1.100	-	-	O	PTHR16160
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X911
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160