Protein Alignment Fit1 and Fit2

DIOPT Version :10

• Sequence 1: NP_647858.2
• Gene: Fit1 / 38488
• FlyBaseID: FBgn0035498
• Length: 708
• Species: Drosophila melanogaster
• Sequence 2: NP_648947.1
• Gene: Fit2 / 39907
• FlyBaseID: FBgn0036688
• Length: 715
• Species: Drosophila melanogaster
• Alignment Length: 716
• Identity: 541/716 - (75%)
• Similarity: 624/716 - (87%)
• Gaps: 9/716 - (1%)

  Fly     1 MIHVGENTWNLRILITDLQVEKTLRVKGDQHIGGVMLNLVDPELPKDWSDHALWWPAKNIWLTRT 65
            |||||||:|||||.||||.:|||:||:|||||||:||.|||||.|||||||||||||:|:||:||
  Fly     1 MIHVGENSWNLRIFITDLALEKTMRVRGDQHIGGIMLQLVDPENPKDWSDHALWWPARNVWLSRT 65

  Fly    66 RSTLDQAGVQSDSFLHFTPMHKTLRVQMPDLRYLDYRVNFSAKTFGAVVSLCKDLDIRYPEELSF 130
            :.||||.|||:||.||||||||.||||:|||||||.||::|.|||.|||:|||.||||||||||.
  Fly    66 KLTLDQCGVQADSLLHFTPMHKILRVQLPDLRYLDSRVDYSVKTFSAVVNLCKQLDIRYPEELSL 130

  Fly   131 CKPLEPEHLKKNFSKLP-QRKIPVAEANGIAYVQPALDTNSFVPITGAYN---GSNGSLDR-SHN 190
            |||||.||||:||:::| |:::|:||.:|..|:|||.||||||||:.:::   ||.||||: |..
  Fly   131 CKPLEAEHLKRNFAQVPHQKRVPIAEPDGTTYLQPAADTNSFVPISTSFHGEGGSTGSLDKPSAP 195

  Fly   191 GNLLCAPASPYTRRAATAPGTPISSPTGTWKHNSTGYASYD-SNSSFGDLQENLAMSPRSPSPDV 254
            |:..|||.||:..| |.:|...:|...||||.:..|||:|| |:||.||.|||||.||.:|..||
  Fly   196 GSFFCAPLSPHNHR-ARSPVRTVSPFPGTWKQSQLGYATYDSSSSSLGDFQENLASSPPTPCADV 259

  Fly   255 RARLVRPKSRVEKARLNVGWLDSSLSIMEQGVREYDTLCLRFKYFTFFDLNPKYDQVRINQLYEQ 319
            ||..:||||.|||||||||||||||||||||:|||||||||||||||||||||.|||||||||||
  Fly   260 RALQLRPKSLVEKARLNVGWLDSSLSIMEQGIREYDTLCLRFKYFTFFDLNPKCDQVRINQLYEQ 324

  Fly   320 AKWSILNEELEPTEEETLMFAALQFQVNHQTDLHPPG--IDSGIDTSSQETGGEDDIDSALNELQ 382
            ||||:|||||:.||||:||||||||||||..|..|.|  :||||:|||||...||:|||||.|||
  Fly   325 AKWSVLNEELDCTEEESLMFAALQFQVNHHVDHTPQGAAVDSGIETSSQENDNEDEIDSALKELQ 389

  Fly   383 ITLEGPGGGKDQGNITRIPELSDYLKFLKPQRFTLKGYKRYFFTYRDLHLHLYKSQDESRRGAPT 447
            ||||||..|.|..||||||||||||::||||||||:|||||:||||||||||:|:.::|||.||.
  Fly   390 ITLEGPDYGGDSRNITRIPELSDYLRYLKPQRFTLRGYKRYYFTYRDLHLHLFKNAEDSRRVAPA 454

  Fly   448 ISINLKGCEVTPDVNLAQGKFAIRLEVPSEIRNGPNSEVWVRCDNEEQYAKWMAACRLAAKGRSL 512
            ||||||||||||||||:|||:||||||..:..:|.||||||||:||:||||||||||||||||||
  Fly   455 ISINLKGCEVTPDVNLSQGKYAIRLEVSPDGGHGINSEVWVRCENEQQYAKWMAACRLAAKGRSL 519

  Fly   513 ADSSYDSEVSSIRSLLQMQKPAQGAPLTVNPRSVEPMDYLSPKMMRKLSSKAVQRILEAHANVRQ 577
            |||||:|||.||.||||||:||.|..:.::|||||.:||||||::||||:||||||||||||||:
  Fly   520 ADSSYESEVDSILSLLQMQRPAHGVHVNIDPRSVEAVDYLSPKIIRKLSNKAVQRILEAHANVRE 584

  Fly   578 LSLMDAKMKYIQAWQSLPDFGVTLFIIKFDGHKKEELLGVANNRIMRMDLNTGDHIKTWRYNTMK 642
            |:.:|:|:||||||:|||||||:|||||||||:||||||||:||||||||::|||||||||||||
  Fly   585 LNALDSKLKYIQAWRSLPDFGVSLFIIKFDGHRKEELLGVAHNRIMRMDLSSGDHIKTWRYNTMK 649

  Fly   643 AWNVNWGIKCMMIQLQDENIVFSVQSADCKVVHEFIGGYIFMSMRSKENNQTLNEEMFHKLTGGW 707
            ||||||.|||||||.:|||:|||..||||||||||||||||||||||:.|||||||:||||||||
  Fly   650 AWNVNWNIKCMMIQFEDENVVFSCHSADCKVVHEFIGGYIFMSMRSKDTNQTLNEELFHKLTGGW 714

  Fly   708 S 708
            |
  Fly   715 S 715

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fit1	NP_647858.2	FERM_F0_kindlins	8..86	CDD:340615	60/77 (78%)
		FERM_F1_kindlins	87..299	CDD:340616	142/217 (65%)
		B41	<274..>363	CDD:214604	76/90 (84%)
		PH_fermitin	401..529	CDD:269943	102/127 (80%)
		FERM_M	<490..602	CDD:459788	85/111 (77%)
		FERM_C_fermitin	596..686	CDD:270026	78/89 (88%)
Fit2	NP_648947.1	FERM_F0_kindlins	8..86	CDD:340615	60/77 (78%)
		FERM_F1_kindlins	87..304	CDD:340616	142/217 (65%)
		B41	259..>351	CDD:214604	81/91 (89%)
		PH_fermitin	408..536	CDD:269943	102/127 (80%)
		FERM_M	<507..609	CDD:459788	77/101 (76%)
		FERM_C_fermitin	603..693	CDD:270026	78/89 (88%)