DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fit1 and fermt3b

DIOPT Version :9

Sequence 1:	NP_647858.2	Gene:	Fit1 / 38488	FlyBaseID:	FBgn0035498	Length:	708	Species:	Drosophila melanogaster
Sequence 2:	NP_957198.2	Gene:	fermt3b / 393878	ZFINID:	ZDB-GENE-040426-1366	Length:	642	Species:	Danio rerio

Alignment Length:	710	Identity:	308/710 - (43%)
Similarity:	432/710 - (60%)	Gaps:	87/710 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 WNLRILITDLQVEK---TLRVKGDQHIGGVMLNLVDPE-LPKDWSDHALWWPAKNIWLTRTRSTL 69
            |:|.:.:.||..:.   .:.|..|.|||||:|.:|:.. |.||||||||||..|..||.||..||
Zfish     4 WDLNVTVEDLGPDAPPLQISVTSDLHIGGVILKIVEKTMLKKDWSDHALWWEQKQQWLLRTGWTL 68

  Fly    70 DQAGVQSDSFLHFTPMHKTLRVQMPDLRYLDYRVNFSAKTFGAVVSLCKDLDIRYPEELSFCKPL 134
            |:.||.:|:.|.|||.||.||:.:|:...|..|..||:..|..|:.:|:.|:||:|||||..:|:
Zfish    69 DKCGVHADARLVFTPQHKPLRLGLPNGATLKMRACFSSPVFRCVMGICRVLNIRHPEELSLLRPV 133

  Fly   135 EPEHLKKNFSKLPQRKIPVAEANGIAYVQPALDTNSFVPITGAYNGSNGSLDRSHNGNLLCAPAS 199
            |.:..||:.....:                 |...:.||:|.      ||:...:||    .||
Zfish   134 EEKKKKKDKDSSEE-----------------LYDLTDVPLTA------GSVQALYNG----MPA- 170

  Fly   200 PYTRRAATAPGTPISSPTGTWKHNSTGYASYDSNSSFGDLQENLAMSPRSPSPDVRARLVRPKSR 264
                ..|.:|.|.               |.|          :.|:.|..||:|:..|:|.||.|.
Zfish   171 ----HFADSPKTE---------------AVY----------KMLSFSLPSPAPEAIAKLYRPASV 206

  Fly   265 VEKARLNVGWLDSSLSIMEQGVREYDTLCLRFKYFTFFDLNPKYDQVRINQLYEQAKWSILNEEL 329
            |:|..::..|||||.|:|:||::|.|.|.|||||:||.|::||||.||:.||||||:|::|.|::
Zfish   207 VDKTHIHTRWLDSSRSLMQQGIQENDKLWLRFKYYTFHDMDPKYDAVRLTQLYEQARWAVLLEDI 271

  Fly   330 EPTEEETLMFAALQFQVNHQTDLHPPGIDSGIDTSSQETG----GEDDIDSALNELQITLEGPGG 390
            :.||||.::|.|||:.:             |..::|||.|    |.||::|||..|::.:.|.|.
Zfish   272 DCTEEEMMLFGALQYHI-------------GKLSTSQEIGSSCQGMDDLESALKSLEVKMVGEGD 323

  Fly   391 GKDQ--GNITRIPELSDYLKFLKPQRFTLKGYKRYFFTYRDLHLHLYKSQDESRRGAPTISINLK 453
            ....  .|:|. |||:||||..:|:|.||||||:|:..::|..:..|||. |.|.|.|...:|||
Zfish   324 STTDMLDNMTP-PELNDYLKIFRPKRLTLKGYKQYWCKFQDTSISYYKSM-EDRYGEPIQQLNLK 386

  Fly   454 GCEVTPDVNLAQGKFAIRLEVPSEIRNGPNSEVWVRCDNEEQYAKWMAACRLAAKGRSLADSSYD 518
            ||||.||||:|..||.|:|.:|:.  .|.| |:::||:||:||::|||.|:||:||.:|.||||.
Zfish   387 GCEVAPDVNIAGQKFCIKLLIPAP--EGMN-EIYLRCENEKQYSEWMAGCKLASKGLTLLDSSYQ 448

  Fly   519 SEVSSIRSLLQMQKPAQGAPLTVNPRSVEPMDYLSPKMMRKLSSKAV-QRILEAHANVRQLSLMD 582
            :||.:|::.|.||:............|:.....:||:..:|...|.: .|||||..||.||||..
Zfish   449 NEVKNIQTFLSMQRSNSSTAAAQTDDSINTHSLVSPRYQKKYKPKQLTPRILEAFQNVAQLSLTS 513

  Fly   583 AKMKYIQAWQSLPDFGVTLFIIKFDGHKKEELLGVANNRIMRMDLNTGDHIKTWRYNTMKAWNVN 647
            |.:|::|.||:|||||::.|:::|.|.:|:|:||:||||::|:||..||.:||||||.|:.||||
Zfish   514 AILKFLQIWQALPDFGISYFMVRFKGSRKDEVLGIANNRLIRIDLGVGDVVKTWRYNNMRQWNVN 578

  Fly   648 WGIKCMMIQLQDE-NIVFSVQSADCKVVHEFIGGYIFMSMRSKENNQTLNEEMFHKLTGG 706
            |.|:.:.|:.... ||.||..:||||||||:||||||||.||::.:.|||||:|||||||
Zfish   579 WDIRQVAIEFDGNINIAFSCVNADCKVVHEYIGGYIFMSTRSRQQSDTLNEELFHKLTGG 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fit1	NP_647858.2	FERM_B-lobe	305..>348	CDD:298919	23/42 (55%)
		PH_fermitin	401..529	CDD:269943	66/127 (52%)
		PH	401..508	CDD:278594	56/106 (53%)
		FERM_M	<538..602	CDD:278785	26/64 (41%)
		FERM_C_fermitin	596..686	CDD:270026	52/90 (58%)
fermt3b	NP_957198.2	B41	<208..>288	CDD:214604	44/79 (56%)
		FERM_M	248..>317	CDD:278785	35/81 (43%)
		PH_fermitin	335..459	CDD:269943	66/127 (52%)
		PH	343..438	CDD:278594	49/98 (50%)
		FERM_M	<471..533	CDD:278785	26/61 (43%)
		FERM_C_fermitin	527..618	CDD:270026	52/90 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591974
Domainoid	1	1.000	297	1.000	Domainoid score	I1426
eggNOG	1	0.900	-	-		E1_KOG3727
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	630	1.000	Inparanoid score	I825
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132272at33208
OrthoFinder	1	1.000	-	-		FOG0001455
OrthoInspector	1	1.000	-	-		mtm6417
orthoMCL	1	0.900	-	-		OOG6_103097
Panther	1	1.100	-	-	O	PTHR16160
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X911
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.760