DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fit1 and Fermt3

DIOPT Version :9

Sequence 1:	NP_647858.2	Gene:	Fit1 / 38488	FlyBaseID:	FBgn0035498	Length:	708	Species:	Drosophila melanogaster
Sequence 2:	NP_001121015.1	Gene:	Fermt3 / 309186	RGDID:	1310168	Length:	665	Species:	Rattus norvegicus

Alignment Length:	721	Identity:	290/721 - (40%)
Similarity:	435/721 - (60%)	Gaps:	92/721 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ENTWNLRILITDLQVEK---TLRVKGDQHIGGVMLNLVDP-ELPKDWSDHALWWPAKNIWLTRTR 66
            :::|.||:.:.:...|.   ||||.|:.|||||:|.:|:. ...:||||||:||..|..||.:|.
  Rat    13 DSSWELRVFVGEEDPEAQSVTLRVTGESHIGGVLLKIVEEINRKQDWSDHAIWWEQKKQWLLQTH 77

  Fly    67 STLDQAGVQSDSFLHFTPMHKTLRVQMPDLRYLDYRVNFSAKTFGAVVSLCKDLDIRYPEELSFC 131
            .|||:.|:.:|:.|.|.|.|:.:.:::|:.|.|..|.:||...|..|.::|:.|.||:|||||..
  Rat    78 WTLDKYGILADARLFFGPQHRPVILRLPNRRVLRLRASFSKPLFQTVAAICRLLSIRHPEELSLL 142

  Fly   132 KPLEPEHLKKNFSKLPQRKIPVAEANGIAYVQPALDTNSFVPITGAYNGSNGSLDRSHNGNLLCA 196
            :..|.:..||      :.|.|..|.:.:..|                              :|..
  Rat   143 RAPEKKEKKK------KEKEPEEEVHDLTRV------------------------------VLAG 171

  Fly   197 PASPYTRRAATAPGTPISSPTGTWKHNSTGYASYDSNSSFGDLQENLAMSPR-SPSPDVRARLVR 260
            ..:|...|                     |..::.|:|:..:...::...|: :|.|.:..||.|
  Rat   172 GVAPTLFR---------------------GMPAHFSDSAQTEACYHMLSRPQPAPDPLLLQRLPR 215

  Fly   261 PKSRVEKARLNVGWLDSSLSIMEQGVREYDTLCLRFKYFTFFDLNPKYDQVRINQLYEQAKWSIL 325
            |.|.::|.:|:..|||||..:|:||::..|.|.|||||::||||:||.|.||:.||||||:|.:|
  Rat   216 PSSLLDKTQLHSRWLDSSRCLMQQGIKAGDVLWLRFKYYSFFDLDPKTDPVRLTQLYEQARWDLL 280

  Fly   326 NEELEPTEEETLMFAALQFQVNHQTDLHPPGIDSGIDTSSQETGGEDDIDSALNELQITLEGPGG 390
            .||::.||||.::|||||:.:|..|      :...:...:....|.||:|:|||.|::.|:|...
  Rat   281 TEEIDCTEEEMMVFAALQYHINKVT------LSGDVGELASGDPGLDDLDAALNNLEVKLKGSAP 339

  Fly   391 GKDQGNITRIPELSDYLKFLKPQRFTLKGYKRYFFTYRDLHLHLYKSQDESRRGAPTISINLKGC 455
            .....::|.||||.|:|:..:|::.|||||::::..::|..|..||||||: .|.|...:|||||
  Rat   340 SDMLDSLTTIPELKDHLRIFRPRKLTLKGYRQHWVIFKDTTLSYYKSQDEA-PGDPIQQLNLKGC 403

  Fly   456 EVTPDVNLAQGKFAIRLEVPSEIRNGPN--SEVWVRCDNEEQYAKWMAACRLAAKGRSLADSSYD 518
            ||.||||::..||.|:|.|||     |.  ||:::||.:|:|||:||||||||:|||::|||||.
  Rat   404 EVVPDVNVSGQKFCIKLLVPS-----PEGMSEIYLRCQDEQQYAQWMAACRLASKGRTMADSSYA 463

  Fly   519 SEVSSIRSLLQMQ-----------KPAQGAPLTVNPRSVEPMDYLSPKMMRKLSSKAV-QRILEA 571
            |||.:|.:.|.:|           || ||  |..:...:.|...::|:..||..:|.: .|||||
  Rat   464 SEVQAILAFLSLQRAGGTNGGSGNKP-QG--LEASAEGLNPYGLVAPRFQRKFKAKQLTPRILEA 525

  Fly   572 HANVRQLSLMDAKMKYIQAWQSLPDFGVTLFIIKFDGHKKEELLGVANNRIMRMDLNTGDHIKTW 636
            |.||.||||.:|::::|||||||||||::..|::|.|.:|:|:||:||||::|:||..||.:|||
  Rat   526 HQNVAQLSLTEAQLRFIQAWQSLPDFGISYVIVRFKGSRKDEILGIANNRLIRIDLAVGDVVKTW 590

  Fly   637 RYNTMKAWNVNWGIKCMMIQLQDE-NIVFSVQSADCKVVHEFIGGYIFMSMRSKENNQTLNEEMF 700
            |::.|:.|||||.|:.:.|:..:. |:.||..||.|::|||:||||||:|.|.:...:.|:|::|
  Rat   591 RFSNMRQWNVNWDIRQVAIEFDEHINVAFSCVSASCRIVHEYIGGYIFLSTRERARGEELDEDLF 655

  Fly   701 HKLTGG 706
            .:||||
  Rat   656 LQLTGG 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fit1	NP_647858.2	FERM_B-lobe	305..>348	CDD:298919	24/42 (57%)
		PH_fermitin	401..529	CDD:269943	68/129 (53%)
		PH	401..508	CDD:278594	56/108 (52%)
		FERM_M	<538..602	CDD:278785	30/64 (47%)
		FERM_C_fermitin	596..686	CDD:270026	46/90 (51%)
Fermt3	NP_001121015.1	Ubiquitin_like_fold	15..97	CDD:421700	36/81 (44%)
		FERM_F1_KIND3	98..254	CDD:340705	54/212 (25%)
		B41	<221..>301	CDD:214604	45/79 (57%)
		PH_fermitin	350..474	CDD:269943	68/129 (53%)
		FERM_M	462..555	CDD:395297	41/95 (43%)
		FERM_C_fermitin	550..641	CDD:270026	46/90 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350300
Domainoid	1	1.000	290	1.000	Domainoid score	I1485
eggNOG	1	0.900	-	-		E1_KOG3727
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	625	1.000	Inparanoid score	I826
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132272at33208
OrthoFinder	1	1.000	-	-		FOG0001455
OrthoInspector	1	1.000	-	-		mtm9058
orthoMCL	1	0.900	-	-		OOG6_103097
Panther	1	1.100	-	-	O	PTHR16160
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X911
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760