Protein Alignment Fit1 and Fermt1

DIOPT Version :10

• Sequence 1: NP_647858.2
• Gene: Fit1 / 38488
• FlyBaseID: FBgn0035498
• Length: 708
• Species: Drosophila melanogaster
• Sequence 2: NP_001099985.1
• Gene: Fermt1 / 296179
• RGDID: 1306816
• Length: 677
• Species: Rattus norvegicus
• Alignment Length: 734
• Identity: 331/734 - (45%)
• Similarity: 465/734 - (63%)
• Gaps: 87/734 - (11%)

  Fly     1 MIHVGENT---WNLRILI----TDLQVEKTLRVKGDQHIGGVMLNLVDP-ELPKDWSDHALWWPA 57
            |:..|:.|   |.|.:.:    .:.|.:.||||.||.|||||||.||:. .:.:||||.||||..
  Rat     1 MLSSGDFTSASWELVVRVDHANEEQQTDITLRVSGDLHIGGVMLKLVEQMNIAQDWSDFALWWEQ 65

  Fly    58 KNIWLTRTRSTLDQAGVQSDSFLHFTPMHKTLRVQMPDLRYLDYRVNFSAKTFGAVVSLCKDLDI 122
            |..||.:|..|||:.|||:|:.|.|||.||.||:::|:.|.:..||:|||..|.||..:||.|:|
  Rat    66 KRCWLLKTHWTLDKCGVQADAKLLFTPQHKMLRLRLPNTRTVRLRVSFSAVVFKAVADICKVLNI 130

  Fly   123 RYPEELSFCKPLEPEHLKKNFSKLPQRKIPVAEANGIAYVQPALDTNSFVPITGAYNGSNGSLDR 187
            |.|||||..|| ..::.||...|....|.||        ::..|:..|       .:.|:||
  Rat   131 RRPEELSLLKP-SGDYCKKKKKKEKNSKEPV--------IEDILNLES-------SSTSSGS--- 176

  Fly   188 SHNGNLLCAPASPYTRRAATAP------GTPISSPTGTWKHNSTGYASYDSNSSFGD---LQEN- 242
                     |.||........|      |||..| |.||               |||   .::|
  Rat   177 ---------PVSPGLYSKTMTPTYDPINGTPALS-TMTW---------------FGDSPLTEQNC 216

  Fly   243 --LAMSPRSPSPDVRARLVRPKSRVEKARLNVGWLDSSLSIMEQGVREYDTLCLRFKYFTFFDLN 305
              ||.|...|||:|.|.:.:|:|.|:||::|.||||||.|:|||.::|.:.|.|||||:||||||
  Rat   217 SVLAFSQPPPSPEVLAEMFQPRSLVDKAKMNAGWLDSSRSLMEQSIQEDEQLLLRFKYYTFFDLN 281

  Fly   306 PKYDQVRINQLYEQAKWSILNEELEPTEEETLMFAALQFQVNHQTDLHPPGIDSGIDTSSQETGG 370
            ||||.||||||||||:|::|.||::.||||.|:|||||:.::.        :....:.....|..
  Rat   282 PKYDAVRINQLYEQARWAVLLEEIDCTEEEMLIFAALQYHISK--------LSLCAEIQDFATKS 338

  Fly   371 E-DDIDSALNELQITLEGPGGGKDQGNITRIPELSDYLKFLKPQRFTLKGYKRYFFTYRDLHLHL 434
            | |::::||:.|::||||........:||.||:|:||||..||::..||.:|:|:|.::|..:..
  Rat   339 EVDEVEAALSSLEVTLEGGKADNTLEDITDIPKLADYLKLFKPKKLMLKAFKQYWFVFKDTSIAY 403

  Fly   435 YKSQDESRRGAPTISINLKGCEVTPDVNLAQGKFAIRLEVPSEIRNGPNSEVWVRCDNEEQYAKW 499
            :|:| |..:|.|...:|::|||:.||||:|..||.|:|.:|  :.:|.| ||::|||:|:|||:|
  Rat   404 FKNQ-ELEQGEPIEKLNIRGCEIVPDVNVAGRKFGIKLLIP--VADGMN-EVYLRCDHEDQYARW 464

  Fly   500 MAACRLAAKGRSLADSSYDSEVSSIRSLLQMQKPAQGAPLTVNPRSVEPMD-----YLSPKMMRK 559
            ||||.||:||:::|||||..||.||.|.|:| |....:||..:  |:|.||     .:||:..:|
  Rat   465 MAACILASKGKTMADSSYQPEVVSILSFLKM-KNRNSSPLVAS--SLESMDMNPECLVSPRCAKK 526

  Fly   560 LSSKAV-QRILEAHANVRQLSLMDAKMKYIQAWQSLPDFGVTLFIIKFDGHKKEELLGVANNRIM 623
            ..||.: .||||||.||.|:.|::||:::||||||||:||:|.::::|.|.||:::|||:.||::
  Rat   527 HKSKQLAARILEAHHNVAQMPLVEAKLQFIQAWQSLPEFGLTYYLVRFKGSKKDDILGVSYNRLI 591

  Fly   624 RMDLNTGDHIKTWRYNTMKAWNVNWGIKCMMIQL-QDENIVFSVQSADCKVVHEFIGGYIFMSMR 687
            |||..||..:.|||:..||.|||||.|:.:.|:. |:.:|.|:..||.||:|||:||||||:|.|
  Rat   592 RMDAVTGIPVTTWRFANMKQWNVNWEIRQVAIEFDQNVSIAFTCLSAGCKIVHEYIGGYIFLSTR 656

  Fly   688 SKENNQTLNEEMFHKLTGG 706
            ||:.|:||:|::|||||||
  Rat   657 SKDQNETLDEDLFHKLTGG 675

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fit1	NP_647858.2	FERM_F0_kindlins	8..86	CDD:340615	42/85 (49%)
		FERM_F1_kindlins	87..299	CDD:340616	81/223 (36%)
		B41	<274..>363	CDD:214604	50/88 (57%)
		PH_fermitin	401..529	CDD:269943	63/127 (50%)
		FERM_M	<490..602	CDD:459788	62/117 (53%)
		FERM_C_fermitin	596..686	CDD:270026	45/90 (50%)
Fermt1	NP_001099985.1	FERM_F0_KIND1	11..94	CDD:340700	41/82 (50%)
		Ubl1_cv_Nsp3_N-like	95..275	CDD:475130	81/223 (36%)
		B41	<250..>322	CDD:214604	50/71 (70%)
		PH_fermitin	370..494	CDD:269943	63/127 (50%)
		FERM_M	<453..570	CDD:459788	63/119 (53%)
		FERM_C_fermitin	564..655	CDD:270026	45/90 (50%)