DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fit1 and Fermt1

DIOPT Version :9

Sequence 1:	NP_647858.2	Gene:	Fit1 / 38488	FlyBaseID:	FBgn0035498	Length:	708	Species:	Drosophila melanogaster
Sequence 2:	NP_001099985.1	Gene:	Fermt1 / 296179	RGDID:	1306816	Length:	677	Species:	Rattus norvegicus

Alignment Length:	734	Identity:	331/734 - (45%)
Similarity:	465/734 - (63%)	Gaps:	87/734 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIHVGENT---WNLRILI----TDLQVEKTLRVKGDQHIGGVMLNLVDP-ELPKDWSDHALWWPA 57
            |:..|:.|   |.|.:.:    .:.|.:.||||.||.|||||||.||:. .:.:||||.||||..
  Rat     1 MLSSGDFTSASWELVVRVDHANEEQQTDITLRVSGDLHIGGVMLKLVEQMNIAQDWSDFALWWEQ 65

  Fly    58 KNIWLTRTRSTLDQAGVQSDSFLHFTPMHKTLRVQMPDLRYLDYRVNFSAKTFGAVVSLCKDLDI 122
            |..||.:|..|||:.|||:|:.|.|||.||.||:::|:.|.:..||:|||..|.||..:||.|:|
  Rat    66 KRCWLLKTHWTLDKCGVQADAKLLFTPQHKMLRLRLPNTRTVRLRVSFSAVVFKAVADICKVLNI 130

  Fly   123 RYPEELSFCKPLEPEHLKKNFSKLPQRKIPVAEANGIAYVQPALDTNSFVPITGAYNGSNGSLDR 187
            |.|||||..|| ..::.||...|....|.||        ::..|:..|       .:.|:||
  Rat   131 RRPEELSLLKP-SGDYCKKKKKKEKNSKEPV--------IEDILNLES-------SSTSSGS--- 176

  Fly   188 SHNGNLLCAPASPYTRRAATAP------GTPISSPTGTWKHNSTGYASYDSNSSFGD---LQEN- 242
                     |.||........|      |||..| |.||               |||   .::|
  Rat   177 ---------PVSPGLYSKTMTPTYDPINGTPALS-TMTW---------------FGDSPLTEQNC 216

  Fly   243 --LAMSPRSPSPDVRARLVRPKSRVEKARLNVGWLDSSLSIMEQGVREYDTLCLRFKYFTFFDLN 305
              ||.|...|||:|.|.:.:|:|.|:||::|.||||||.|:|||.::|.:.|.|||||:||||||
  Rat   217 SVLAFSQPPPSPEVLAEMFQPRSLVDKAKMNAGWLDSSRSLMEQSIQEDEQLLLRFKYYTFFDLN 281

  Fly   306 PKYDQVRINQLYEQAKWSILNEELEPTEEETLMFAALQFQVNHQTDLHPPGIDSGIDTSSQETGG 370
            ||||.||||||||||:|::|.||::.||||.|:|||||:.::.        :....:.....|..
  Rat   282 PKYDAVRINQLYEQARWAVLLEEIDCTEEEMLIFAALQYHISK--------LSLCAEIQDFATKS 338

  Fly   371 E-DDIDSALNELQITLEGPGGGKDQGNITRIPELSDYLKFLKPQRFTLKGYKRYFFTYRDLHLHL 434
            | |::::||:.|::||||........:||.||:|:||||..||::..||.:|:|:|.::|..:..
  Rat   339 EVDEVEAALSSLEVTLEGGKADNTLEDITDIPKLADYLKLFKPKKLMLKAFKQYWFVFKDTSIAY 403

  Fly   435 YKSQDESRRGAPTISINLKGCEVTPDVNLAQGKFAIRLEVPSEIRNGPNSEVWVRCDNEEQYAKW 499
            :|:| |..:|.|...:|::|||:.||||:|..||.|:|.:|  :.:|.| ||::|||:|:|||:|
  Rat   404 FKNQ-ELEQGEPIEKLNIRGCEIVPDVNVAGRKFGIKLLIP--VADGMN-EVYLRCDHEDQYARW 464

  Fly   500 MAACRLAAKGRSLADSSYDSEVSSIRSLLQMQKPAQGAPLTVNPRSVEPMD-----YLSPKMMRK 559
            ||||.||:||:::|||||..||.||.|.|:| |....:||..:  |:|.||     .:||:..:|
  Rat   465 MAACILASKGKTMADSSYQPEVVSILSFLKM-KNRNSSPLVAS--SLESMDMNPECLVSPRCAKK 526

  Fly   560 LSSKAV-QRILEAHANVRQLSLMDAKMKYIQAWQSLPDFGVTLFIIKFDGHKKEELLGVANNRIM 623
            ..||.: .||||||.||.|:.|::||:::||||||||:||:|.::::|.|.||:::|||:.||::
  Rat   527 HKSKQLAARILEAHHNVAQMPLVEAKLQFIQAWQSLPEFGLTYYLVRFKGSKKDDILGVSYNRLI 591

  Fly   624 RMDLNTGDHIKTWRYNTMKAWNVNWGIKCMMIQL-QDENIVFSVQSADCKVVHEFIGGYIFMSMR 687
            |||..||..:.|||:..||.|||||.|:.:.|:. |:.:|.|:..||.||:|||:||||||:|.|
  Rat   592 RMDAVTGIPVTTWRFANMKQWNVNWEIRQVAIEFDQNVSIAFTCLSAGCKIVHEYIGGYIFLSTR 656

  Fly   688 SKENNQTLNEEMFHKLTGG 706
            ||:.|:||:|::|||||||
  Rat   657 SKDQNETLDEDLFHKLTGG 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fit1	NP_647858.2	FERM_B-lobe	305..>348	CDD:298919	29/42 (69%)
		PH_fermitin	401..529	CDD:269943	63/127 (50%)
		PH	401..508	CDD:278594	51/106 (48%)
		FERM_M	<538..602	CDD:278785	34/69 (49%)
		FERM_C_fermitin	596..686	CDD:270026	45/90 (50%)
Fermt1	NP_001099985.1	B41	<250..>322	CDD:214604	50/71 (70%)
		FERM_M	281..>322	CDD:278785	29/40 (73%)
		PH_fermitin	370..494	CDD:269943	63/127 (50%)
		PH	378..473	CDD:278594	45/98 (46%)
		FERM_M	<515..570	CDD:278785	28/54 (52%)
		FERM_C_fermitin	564..655	CDD:270026	45/90 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350298
Domainoid	1	1.000	290	1.000	Domainoid score	I1485
eggNOG	1	0.900	-	-		E1_KOG3727
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	625	1.000	Inparanoid score	I826
OMA	1	1.010	-	-		QHG48345
OrthoDB	1	1.010	-	-		D132272at33208
OrthoFinder	1	1.000	-	-		FOG0001455
OrthoInspector	1	1.000	-	-		mtm9058
orthoMCL	1	0.900	-	-		OOG6_103097
Panther	1	1.100	-	-	LDO	PTHR16160
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X911
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770