DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fit1 and Fermt2

DIOPT Version :9

Sequence 1:	NP_647858.2	Gene:	Fit1 / 38488	FlyBaseID:	FBgn0035498	Length:	708	Species:	Drosophila melanogaster
Sequence 2:	XP_006251817.1	Gene:	Fermt2 / 289992	RGDID:	1311799	Length:	706	Species:	Rattus norvegicus

Alignment Length:	757	Identity:	339/757 - (44%)
Similarity:	472/757 - (62%)	Gaps:	121/757 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ENTWNLRILITDLQVEKTLRVKGDQHIGGVMLNLVDP-ELPKDWSDHALWWPAKNIWLTRTRSTL 69
            :.||.|.:.:|||..:.||||.|:.|||||||.||:. ::.||||||||||..|..||.:|..||
  Rat    15 DGTWELSVHVTDLNRDVTLRVTGEVHIGGVMLKLVEKLDVKKDWSDHALWWEKKKTWLLKTHWTL 79

  Fly    70 DQAGVQSDSFLHFTPMHKTLRVQMPDLRYLDYRVNFSAKTFGAVVSLCKDLDIRYPEELSFC-KP 133
            |:.|:|:|:.|.|||.||.||:|:|:::|:..:||||.:.|.||..:||..:||:|||||.. ||
  Rat    80 DKYGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDRVFKAVSDICKTFNIRHPEELSLLKKP 144

  Fly   134 LEPEHLKKNFSKLPQRK--------------------IPVAEANGIAYVQPALDTNSFVPITGAY 178
            .:|  .||...||..:.                    :.:....|..|..|.|.:.:..|...|:
  Rat   145 RDP--TKKKKKKLDDQSEDEALELEGPLIMPGSGTDVLYIGPLKGSIYSSPGLYSKTMTPTYDAH 207

  Fly   179 NGSNGSLDRSHNGNLLCAPASPYTRRAATAPGTPISSPTGTWKHNSTGYASYDSNSSFGD--LQE 241
            :||                              |: |||..|               |||  |.|
  Rat   208 DGS------------------------------PL-SPTSAW---------------FGDSALSE 226

  Fly   242 N----LAMSPRSPSPDVRARLVRPKSRVEKARLNVGWLDSSLSIMEQGVREYDTLCLRFKYFTFF 302
            .    ||:|....||::.|::.:|::.::||:.|.||||||.|:|||.|:|.:.|.|||||::||
  Rat   227 GNPGILAVSQPVTSPEILAKMFKPQALLDKAKTNQGWLDSSRSLMEQDVKENEALLLRFKYYSFF 291

  Fly   303 DLNPKYDQVRINQLYEQAKWSILNEELEPTEEETLMFAALQFQVNHQTDLHPPGIDSGIDTSSQE 367
            |||||||.:|||||||||||::|.||:|.||||.:||||||:.:|..:.:..   ::.::.|.:|
  Rat   292 DLNPKYDAIRINQLYEQAKWALLLEEIECTEEEMMMFAALQYHINKLSIMTS---ENHLNNSDKE 353

  Fly   368 TGGEDDIDSALNELQITLEGPGGGKDQGNITRIPELSDYLKFLKPQRFTLKGYKRYFFTYRDLHL 432
            .   |::|:||::|:|||||.......|:||.||||:||:|..||::.||||||:|:.|::|..:
  Rat   354 V---DEVDAALSDLEITLEGGKTSTILGDITSIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSI 415

  Fly   433 HLYKSQDESRRGAPTISINLKGCEVTPDVNLAQGKFAIRLEVPSEIRNGPNSEVWVRCDNEEQYA 497
            ..|||::|: .|.|...:||:|||||||||::..||.|:|.:|  :..|.| |:|:|||||:|||
  Rat   416 SCYKSREEA-SGTPAHQMNLRGCEVTPDVNISGQKFNIKLLIP--VAEGMN-EIWLRCDNEKQYA 476

  Fly   498 KWMAACRLAAKGRSLADSSYDSEVSSIRSLLQMQKPAQGAPLTVNP----------RSVEPMDYL 552
            .||||||||:||:::|||||:.||.:|.|.|:||.        :||          ..:.|...:
  Rat   477 HWMAACRLASKGKTMADSSYNLEVQNILSFLKMQH--------LNPDPQLIPDQITTDINPECLV 533

  Fly   553 SPKMMRKLSSK----------------AVQRILEAHANVRQLSLMDAKMKYIQAWQSLPDFGVTL 601
            ||:.::|..:|                ...||||||.||.|:||::|||::||||||||:||:|.
  Rat   534 SPRYLKKYKNKQEKGCKKQMPGYVRELITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITH 598

  Fly   602 FIIKFDGHKKEELLGVANNRIMRMDLNTGDHIKTWRYNTMKAWNVNWGIKCMMIQLQDE-NIVFS 665
            ||.:|.|.|:|||:|:|.||::|||.:|||.|||||::.||.|||||.||.:.::..|| .:.|.
  Rat   599 FIARFQGGKREELIGIAYNRLIRMDASTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEVRLSFI 663

  Fly   666 VQSADCKVVHEFIGGYIFMSMRSKENNQTLNEEMFHKLTGGW 707
            ....||||||||||||||:|.|:|:.|::|:||||:|||.||
  Rat   664 CTEVDCKVVHEFIGGYIFLSTRAKDQNESLDEEMFYKLTSGW 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fit1	NP_647858.2	FERM_B-lobe	305..>348	CDD:298919	30/42 (71%)
		PH_fermitin	401..529	CDD:269943	70/127 (55%)
		PH	401..508	CDD:278594	59/106 (56%)
		FERM_M	<538..602	CDD:278785	32/89 (36%)
		FERM_C_fermitin	596..686	CDD:270026	52/90 (58%)
Fermt2	XP_006251817.1	PH_fermitin	384..508	CDD:269943	70/127 (55%)
		PH	392..487	CDD:278594	53/98 (54%)
		FERM_M	<520..599	CDD:278785	30/78 (38%)
		PH-like	593..684	CDD:302622	52/90 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350299
Domainoid	1	1.000	290	1.000	Domainoid score	I1485
eggNOG	1	0.900	-	-		E1_KOG3727
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4976
Inparanoid	1	1.050	625	1.000	Inparanoid score	I826
OMA	1	1.010	-	-		QHG48345
OrthoDB	1	1.010	-	-		D132272at33208
OrthoFinder	1	1.000	-	-		FOG0001455
OrthoInspector	1	1.000	-	-		mtm9058
orthoMCL	1	0.900	-	-		OOG6_103097
Panther	1	1.100	-	-	O	PTHR16160
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X911
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770