DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fit1 and FERMT2

DIOPT Version :9

Sequence 1:	NP_647858.2	Gene:	Fit1 / 38488	FlyBaseID:	FBgn0035498	Length:	708	Species:	Drosophila melanogaster
Sequence 2:	XP_006720071.1	Gene:	FERMT2 / 10979	HGNCID:	15767	Length:	706	Species:	Homo sapiens

Alignment Length:	757	Identity:	342/757 - (45%)
Similarity:	473/757 - (62%)	Gaps:	121/757 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ENTWNLRILITDLQVEKTLRVKGDQHIGGVMLNLVDP-ELPKDWSDHALWWPAKNIWLTRTRSTL 69
            :.||.|.:.:|||..:.||||.|:.|||||||.||:. ::.||||||||||..|..||.:|..||
Human    15 DGTWELSVHVTDLNRDVTLRVTGEVHIGGVMLKLVEKLDVKKDWSDHALWWEKKRTWLLKTHWTL 79

  Fly    70 DQAGVQSDSFLHFTPMHKTLRVQMPDLRYLDYRVNFSAKTFGAVVSLCKDLDIRYPEELSFC-KP 133
            |:.|:|:|:.|.|||.||.||:|:|:::|:..:||||.:.|.||..:||..:||:|||||.. ||
Human    80 DKYGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDRVFKAVSDICKTFNIRHPEELSLLKKP 144

  Fly   134 LEPEHLKKNFSKLPQRK--------------------IPVAEANGIAYVQPALDTNSFVPITGAY 178
            .:|  .||...||..:.                    :.:....|..|..|.|.:.:..|...|:
Human   145 RDP--TKKKKKKLDDQSEDEALELEGPLITPGSGTDVLYIGPLKGSIYSSPGLYSKTMTPTYDAH 207

  Fly   179 NGSNGSLDRSHNGNLLCAPASPYTRRAATAPGTPISSPTGTWKHNSTGYASYDSNSSFGD--LQE 241
            :||                              |: |||..|               |||  |.|
Human   208 DGS------------------------------PL-SPTSAW---------------FGDSALSE 226

  Fly   242 N----LAMSPRSPSPDVRARLVRPKSRVEKARLNVGWLDSSLSIMEQGVREYDTLCLRFKYFTFF 302
            .    ||:|....||::.|::.:|::.::||::|.||||||.|:|||.|:|.:.|.|||||::||
Human   227 GNPGILAVSQPITSPEILAKMFKPQALLDKAKINQGWLDSSRSLMEQDVKENEALLLRFKYYSFF 291

  Fly   303 DLNPKYDQVRINQLYEQAKWSILNEELEPTEEETLMFAALQFQVNHQTDLHPPGIDSGIDTSSQE 367
            |||||||.:|||||||||||:||.||:|.||||.:||||||:.:|..:.:..   ::.::.|.:|
Human   292 DLNPKYDAIRINQLYEQAKWAILLEEIECTEEEMMMFAALQYHINKLSIMTS---ENHLNNSDKE 353

  Fly   368 TGGEDDIDSALNELQITLEGPGGGKDQGNITRIPELSDYLKFLKPQRFTLKGYKRYFFTYRDLHL 432
            .   |::|:||::|:|||||.......|:||.||||:||:|..||::.||||||:|:.|::|..:
Human   354 V---DEVDAALSDLEITLEGGKTSTILGDITSIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSI 415

  Fly   433 HLYKSQDESRRGAPTISINLKGCEVTPDVNLAQGKFAIRLEVPSEIRNGPNSEVWVRCDNEEQYA 497
            ..|||::|| .|.|...:||:|||||||||::..||.|:|.:|  :..|.| |:|:|||||:|||
Human   416 SCYKSKEES-SGTPAHQMNLRGCEVTPDVNISGQKFNIKLLIP--VAEGMN-EIWLRCDNEKQYA 476

  Fly   498 KWMAACRLAAKGRSLADSSYDSEVSSIRSLLQMQKPAQGAPLTVNP----------RSVEPMDYL 552
            .||||||||:||:::|||||:.||.:|.|.|:||.        :||          ..:.|...:
Human   477 HWMAACRLASKGKTMADSSYNLEVQNILSFLKMQH--------LNPDPQLIPEQITTDITPECLV 533

  Fly   553 SPKMMRKLSSK----------------AVQRILEAHANVRQLSLMDAKMKYIQAWQSLPDFGVTL 601
            ||:.::|..:|                ...||||||.||.|:||::|||::||||||||:||:|.
Human   534 SPRYLKKYKNKQEKGCKKHMPGYIRDLITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITH 598

  Fly   602 FIIKFDGHKKEELLGVANNRIMRMDLNTGDHIKTWRYNTMKAWNVNWGIKCMMIQLQDE-NIVFS 665
            ||.:|.|.|||||:|:|.||::|||.:|||.|||||::.||.|||||.||.:.::..|| .:.|.
Human   599 FIARFQGGKKEELIGIAYNRLIRMDASTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEVRLSFI 663

  Fly   666 VQSADCKVVHEFIGGYIFMSMRSKENNQTLNEEMFHKLTGGW 707
            ....||||||||||||||:|.|:|:.|::|:||||:|||.||
Human   664 CTEVDCKVVHEFIGGYIFLSTRAKDQNESLDEEMFYKLTSGW 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fit1	NP_647858.2	FERM_B-lobe	305..>348	CDD:298919	31/42 (74%)
		PH_fermitin	401..529	CDD:269943	71/127 (56%)
		PH	401..508	CDD:278594	60/106 (57%)
		FERM_M	<538..602	CDD:278785	32/89 (36%)
		FERM_C_fermitin	596..686	CDD:270026	53/90 (59%)
FERMT2	XP_006720071.1	FERM_B-lobe	294..>337	CDD:298919	31/42 (74%)
		PH_fermitin	384..508	CDD:269943	71/127 (56%)
		PH	392..487	CDD:278594	54/98 (55%)
		FERM_M	<520..599	CDD:278785	30/78 (38%)
		FERM_C_fermitin	593..684	CDD:270026	53/90 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156365
Domainoid	1	1.000	298	1.000	Domainoid score	I1454
eggNOG	1	0.900	-	-		E1_KOG3727
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4976
Inparanoid	1	1.050	636	1.000	Inparanoid score	I828
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48345
OrthoDB	1	1.010	-	-		D132272at33208
OrthoFinder	1	1.000	-	-		FOG0001455
OrthoInspector	1	1.000	-	-		mtm8583
orthoMCL	1	0.900	-	-		OOG6_103097
Panther	1	1.100	-	-	O	PTHR16160
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2884
SonicParanoid	1	1.000	-	-		X911
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800