Protein Alignment Fit1 and Fermt3

DIOPT Version :10

• Sequence 1: NP_647858.2
• Gene: Fit1 / 38488
• FlyBaseID: FBgn0035498
• Length: 708
• Species: Drosophila melanogaster
• Sequence 2: NP_722490.1
• Gene: Fermt3 / 108101
• MGIID: 2147790
• Length: 665
• Species: Mus musculus
• Alignment Length: 733
• Identity: 294/733 - (40%)
• Similarity: 436/733 - (59%)
• Gaps: 116/733 - (15%)

  Fly     6 ENTWNLRILITDLQVEK---TLRVKGDQHIGGVMLNLVDP-ELPKDWSDHALWWPAKNIWLTRTR 66
            :::|.||:.:.:...|.   ||||.|:.|||||:|.:|:. ...:||||||:||..|..||.:|.
Mouse    13 DSSWELRVFVGEEDPEAQSVTLRVTGESHIGGVLLKIVEEINRKQDWSDHAIWWEQKRQWLLQTH 77

  Fly    67 STLDQAGVQSDSFLHFTPMHKTLRVQMPDLRYLDYRVNFSAKTFGAVVSLCKDLDIRYPEELSFC 131
            .|||:.|:.:|:.|.|.|.|:.:.:::|:.|.|..|.:||...|..|.::|:.|.||:|||||..
Mouse    78 WTLDKYGILADARLFFGPQHRPVILRLPNRRVLRLRASFSKPLFQTVAAICRLLSIRHPEELSLL 142

  Fly   132 KPLEPEHLKKNFSKLPQRKI----PVAEANGIAYVQPALDTNSFVPITGAYNGSNGSLDRSHNGN 192
            :..|.:..||. .|.|:.::    .|..|.|:|   |.|
Mouse   143 RAPEKKEKKKK-EKEPEEEVHDLTKVVLAGGVA---PTL-------------------------- 177

  Fly   193 LLCAPASPYTRRAATAPGTPISSPTGTWKHNSTGYASYDSNSSFGDLQENLAMSPR-SPSPDVRA 256
                                           ..|..::.|:|:..:...::...|: :|.|.:..
Mouse   178 -------------------------------FRGMPAHFSDSAQTEACYHMLSRPQPAPDPLLLQ 211

  Fly   257 RLVRPKSRVEKARLNVGWLDSSLSIMEQGVREYDTLCLRFKYFTFFDLNPKYDQVRINQLYEQAK 321
            ||.||.|..:|.:|:..|||||..:|:||::..|.|.|||||::||||:||.|.||:.||||||:
Mouse   212 RLPRPSSLPDKTQLHSRWLDSSRCLMQQGIKAGDVLWLRFKYYSFFDLDPKTDPVRLTQLYEQAR 276

  Fly   322 WSILNEELEPTEEETLMFAALQFQVNHQTDLHPPGIDSGIDTSSQETG--GEDDIDSALNELQIT 384
            |.:|.||::.||||.::|||||:.:|..|       .|| |.....:|  |.||:|:|||.|::.
Mouse   277 WDLLTEEIDCTEEEMMVFAALQYHINKLT-------LSG-DVGELASGDLGLDDLDAALNNLEVK 333

  Fly   385 LEGPGGGKDQGNITRIPELSDYLKFLKPQRFTLKGYKRYFFTYRDLHLHLYKSQDESRRGAPTIS 449
            |:|........::|.||||.|:|:..:|::.|||||::|:..::|..|..||||||: .|.||..
Mouse   334 LKGSAPSDMLDSLTTIPELKDHLRIFRPRKLTLKGYRQYWVVFKDTTLSYYKSQDEA-PGDPTQQ 397

  Fly   450 INLKGCEVTPDVNLAQGKFAIRLEVPSEIRNGPN--SEVWVRCDNEEQYAKWMAACRLAAKGRSL 512
            :|||||||.||||::..||.|:|.|||     |.  ||:::||.:|:|||:||||||||:|||::
Mouse   398 LNLKGCEVVPDVNVSGQKFCIKLLVPS-----PEGMSEIYLRCQDEQQYAQWMAACRLASKGRTM 457

  Fly   513 ADSSYDSEVSSIRSLLQMQK-----------------PAQGAPLTVNPRSVEPMDYLSPKMMRKL 560
            |||||.|||.:|.:.|.:|:                 ||:|         :.|...::|:..||.
Mouse   458 ADSSYASEVQAILAFLSLQRAGGSNGGSGNKPQGPEAPAEG---------LNPYGLVAPRFQRKF 513

  Fly   561 SSKAV-QRILEAHANVRQLSLMDAKMKYIQAWQSLPDFGVTLFIIKFDGHKKEELLGVANNRIMR 624
            .:|.: .||||||.||.||||.:|::::|||||||||||::..:::|.|.:|:|:||:||||::|
Mouse   514 KAKQLTPRILEAHQNVAQLSLTEAQLRFIQAWQSLPDFGISYVMVRFKGSRKDEILGIANNRLIR 578

  Fly   625 MDLNTGDHIKTWRYNTMKAWNVNWGIKCMMIQLQDE-NIVFSVQSADCKVVHEFIGGYIFMSMRS 688
            :||..||.:||||::.|:.|||||.|:.:.|:..:. |:.||..||.|::|||:||||||:|.|.
Mouse   579 IDLAVGDVVKTWRFSNMRQWNVNWDIRQVAIEFDEHINVAFSCVSASCRIVHEYIGGYIFLSTRE 643

  Fly   689 KENNQTLNEEMFHKLTGG 706
            :...:.|:|::|.:||||
Mouse   644 RARGEELDEDLFLQLTGG 661

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fit1	NP_647858.2	FERM_F0_kindlins	8..86	CDD:340615	36/81 (44%)
		FERM_F1_kindlins	87..299	CDD:340616	55/216 (25%)
		B41	<274..>363	CDD:214604	47/88 (53%)
		PH_fermitin	401..529	CDD:269943	70/129 (54%)
		FERM_M	<490..602	CDD:459788	59/129 (46%)
		FERM_C_fermitin	596..686	CDD:270026	45/90 (50%)
Fermt3	NP_722490.1	Ubl1_cv_Nsp3_N-like	15..97	CDD:475130	36/81 (44%)
		FERM_F1_KIND3	98..254	CDD:340705	55/216 (25%)
		B41	<221..>301	CDD:214604	45/79 (57%)
		PH_fermitin	350..474	CDD:269943	70/129 (54%)
		FERM_M	<433..555	CDD:459788	60/130 (46%)
		FERM_C_fermitin	550..641	CDD:270026	45/90 (50%)