DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fit1 and Fermt3

DIOPT Version :9

Sequence 1:	NP_647858.2	Gene:	Fit1 / 38488	FlyBaseID:	FBgn0035498	Length:	708	Species:	Drosophila melanogaster
Sequence 2:	NP_001349328.1	Gene:	Fermt3 / 108101	MGIID:	2147790	Length:	665	Species:	Mus musculus

Alignment Length:	733	Identity:	294/733 - (40%)
Similarity:	436/733 - (59%)	Gaps:	116/733 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ENTWNLRILITDLQVEK---TLRVKGDQHIGGVMLNLVDP-ELPKDWSDHALWWPAKNIWLTRTR 66
            :::|.||:.:.:...|.   ||||.|:.|||||:|.:|:. ...:||||||:||..|..||.:|.
Mouse    13 DSSWELRVFVGEEDPEAQSVTLRVTGESHIGGVLLKIVEEINRKQDWSDHAIWWEQKRQWLLQTH 77

  Fly    67 STLDQAGVQSDSFLHFTPMHKTLRVQMPDLRYLDYRVNFSAKTFGAVVSLCKDLDIRYPEELSFC 131
            .|||:.|:.:|:.|.|.|.|:.:.:::|:.|.|..|.:||...|..|.::|:.|.||:|||||..
Mouse    78 WTLDKYGILADARLFFGPQHRPVILRLPNRRVLRLRASFSKPLFQTVAAICRLLSIRHPEELSLL 142

  Fly   132 KPLEPEHLKKNFSKLPQRKI----PVAEANGIAYVQPALDTNSFVPITGAYNGSNGSLDRSHNGN 192
            :..|.:..||. .|.|:.::    .|..|.|:|   |.|
Mouse   143 RAPEKKEKKKK-EKEPEEEVHDLTKVVLAGGVA---PTL-------------------------- 177

  Fly   193 LLCAPASPYTRRAATAPGTPISSPTGTWKHNSTGYASYDSNSSFGDLQENLAMSPR-SPSPDVRA 256
                                           ..|..::.|:|:..:...::...|: :|.|.:..
Mouse   178 -------------------------------FRGMPAHFSDSAQTEACYHMLSRPQPAPDPLLLQ 211

  Fly   257 RLVRPKSRVEKARLNVGWLDSSLSIMEQGVREYDTLCLRFKYFTFFDLNPKYDQVRINQLYEQAK 321
            ||.||.|..:|.:|:..|||||..:|:||::..|.|.|||||::||||:||.|.||:.||||||:
Mouse   212 RLPRPSSLPDKTQLHSRWLDSSRCLMQQGIKAGDVLWLRFKYYSFFDLDPKTDPVRLTQLYEQAR 276

  Fly   322 WSILNEELEPTEEETLMFAALQFQVNHQTDLHPPGIDSGIDTSSQETG--GEDDIDSALNELQIT 384
            |.:|.||::.||||.::|||||:.:|..|       .|| |.....:|  |.||:|:|||.|::.
Mouse   277 WDLLTEEIDCTEEEMMVFAALQYHINKLT-------LSG-DVGELASGDLGLDDLDAALNNLEVK 333

  Fly   385 LEGPGGGKDQGNITRIPELSDYLKFLKPQRFTLKGYKRYFFTYRDLHLHLYKSQDESRRGAPTIS 449
            |:|........::|.||||.|:|:..:|::.|||||::|:..::|..|..||||||: .|.||..
Mouse   334 LKGSAPSDMLDSLTTIPELKDHLRIFRPRKLTLKGYRQYWVVFKDTTLSYYKSQDEA-PGDPTQQ 397

  Fly   450 INLKGCEVTPDVNLAQGKFAIRLEVPSEIRNGPN--SEVWVRCDNEEQYAKWMAACRLAAKGRSL 512
            :|||||||.||||::..||.|:|.|||     |.  ||:::||.:|:|||:||||||||:|||::
Mouse   398 LNLKGCEVVPDVNVSGQKFCIKLLVPS-----PEGMSEIYLRCQDEQQYAQWMAACRLASKGRTM 457

  Fly   513 ADSSYDSEVSSIRSLLQMQK-----------------PAQGAPLTVNPRSVEPMDYLSPKMMRKL 560
            |||||.|||.:|.:.|.:|:                 ||:|         :.|...::|:..||.
Mouse   458 ADSSYASEVQAILAFLSLQRAGGSNGGSGNKPQGPEAPAEG---------LNPYGLVAPRFQRKF 513

  Fly   561 SSKAV-QRILEAHANVRQLSLMDAKMKYIQAWQSLPDFGVTLFIIKFDGHKKEELLGVANNRIMR 624
            .:|.: .||||||.||.||||.:|::::|||||||||||::..:::|.|.:|:|:||:||||::|
Mouse   514 KAKQLTPRILEAHQNVAQLSLTEAQLRFIQAWQSLPDFGISYVMVRFKGSRKDEILGIANNRLIR 578

  Fly   625 MDLNTGDHIKTWRYNTMKAWNVNWGIKCMMIQLQDE-NIVFSVQSADCKVVHEFIGGYIFMSMRS 688
            :||..||.:||||::.|:.|||||.|:.:.|:..:. |:.||..||.|::|||:||||||:|.|.
Mouse   579 IDLAVGDVVKTWRFSNMRQWNVNWDIRQVAIEFDEHINVAFSCVSASCRIVHEYIGGYIFLSTRE 643

  Fly   689 KENNQTLNEEMFHKLTGG 706
            :...:.|:|::|.:||||
Mouse   644 RARGEELDEDLFLQLTGG 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fit1	NP_647858.2	FERM_B-lobe	305..>348	CDD:298919	24/42 (57%)
		PH_fermitin	401..529	CDD:269943	70/129 (54%)
		PH	401..508	CDD:278594	58/108 (54%)
		FERM_M	<538..602	CDD:278785	29/64 (45%)
		FERM_C_fermitin	596..686	CDD:270026	45/90 (50%)
Fermt3	NP_001349328.1	B41	<221..>301	CDD:214604	45/79 (57%)
		PH_fermitin	350..474	CDD:269943	70/129 (54%)
		FERM_M	<490..555	CDD:306805	32/73 (44%)
		FERM_C_fermitin	550..641	CDD:270026	45/90 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846768
Domainoid	1	1.000	300	1.000	Domainoid score	I1416
eggNOG	1	0.900	-	-		E1_KOG3727
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	636	1.000	Inparanoid score	I832
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132272at33208
OrthoFinder	1	1.000	-	-		FOG0001455
OrthoInspector	1	1.000	-	-		mtm8811
orthoMCL	1	0.900	-	-		OOG6_103097
Panther	1	1.100	-	-	O	PTHR16160
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X911
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.760