DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fit1 and fermt3a

DIOPT Version :10

Sequence 1:NP_647858.2 Gene:Fit1 / 38488 FlyBaseID:FBgn0035498 Length:708 Species:Drosophila melanogaster
Sequence 2:XP_021332356.1 Gene:fermt3a / 100320305 ZFINID:ZDB-GENE-081031-46 Length:641 Species:Danio rerio


Alignment Length:706 Identity:302/706 - (42%)
Similarity:430/706 - (60%) Gaps:80/706 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 WNLRILITDLQVEK---TLRVKGDQHIGGVMLNLVD-PELPKDWSDHALWWPAKNIWLTRTRSTL 69
            |:|.|::.:|..:.   .:.|..|.|||||:|.:|: .::.||||||||||..|..||.:...||
Zfish     4 WDLSIMVEELGPQAPPLKISVTSDLHIGGVILKVVEKSQIKKDWSDHALWWEQKQQWLLKPSWTL 68

  Fly    70 DQAGVQSDSFLHFTPMHKTLRVQMPDLRYLDYRVNFSAKTFGAVVSLCKDLDIRYPEELSFCKPL 134
            |:.|:.:|:.|..||.||.||:.||:...:..||.||...|..|:.:||.|:||:|||||...|:
Zfish    69 DKCGIHADARLCLTPQHKPLRLLMPNAITVCMRVCFSNPVFRTVMGICKVLNIRHPEELSLLWPV 133

  Fly   135 EPEHLKKNFSKLPQRKIPVAEANGIAYVQPALDTNSFVPITGAYNGSNGSLDRSHNGNLLCAPAS 199
            |.:..||:..        |.|.                    .|:.::..|           |:|
Zfish   134 EEKKKKKDKD--------VGEE--------------------VYDITSAPL-----------PSS 159

  Fly   200 PYTRRAATAPGTPISSPTGTWKHNSTGYASYDSNSSFGDLQENLAMSPRSPSPDVRARLVRPKSR 264
            ...:.|...|.....:|              :|.:.:    :.||:|...|:|::.|:..|..:.
Zfish   160 TILKLANGMPAFFAETP--------------ESEAVY----KMLAVSQPPPAPEIIAKTYRSTNI 206

  Fly   265 VEKARLNVGWLDSSLSIMEQGVREYDTLCLRFKYFTFFDLNPKYDQVRINQLYEQAKWSILNEEL 329
            :|||::|..|||||.|:::|||:|.|.|.|||||::|.|:.|:.|.||:.||||||:|:||.||:
Zfish   207 MEKAQINGRWLDSSRSLLQQGVKENDKLILRFKYYSFHDVIPQSDVVRLTQLYEQARWAILLEEI 271

  Fly   330 EPTEEETLMFAALQFQVNHQTDLHPPGIDSGIDTSSQETGGEDDIDSALNELQITLEGPGGGKDQ 394
            |.||||.::|||||:.:         |..|..:.........||:||||..|::.:||.....|.
Zfish   272 ECTEEEMMVFAALQYHI---------GKVSLTEQLVASCPAMDDLDSALQCLEVKMEGESSADDM 327

  Fly   395 GNITRIPELSDYLKFLKPQRFTLKGYKRYFFTYRDLHLHLYKSQDESRRGAPTISINLKGCEVTP 459
            ......|||.||||..:|:|.||||||:|:||::|..:..|||::||.: .|...:|||||||.|
Zfish   328 LETMTAPELHDYLKIFRPKRLTLKGYKQYWFTFKDTTISYYKSKEESCK-EPIQQMNLKGCEVAP 391

  Fly   460 DVNLAQGKFAIRLEVPSEIRNGPN--SEVWVRCDNEEQYAKWMAACRLAAKGRSLADSSYDSEVS 522
            ||::|..||.|||.:|     ||.  :||::||::|:||::||||||||:||::|||||:.:||.
Zfish   392 DVSVAGQKFCIRLLIP-----GPEGMNEVYLRCEHEQQYSRWMAACRLASKGKTLADSSFSNEVQ 451

  Fly   523 SIRSLLQMQKPAQGAPLTVNPRSVEPMDYLSPKMMRKLSSKAV-QRILEAHANVRQLSLMDAKMK 586
            ||:|.|.|||............|:.....:||:..:|...|.: .|||||:.||.||||.||..|
Zfish   452 SIQSFLAMQKTTPSNNTAQTDESINTHSLVSPRYQKKYKPKQLTPRILEAYQNVAQLSLTDAIQK 516

  Fly   587 YIQAWQSLPDFGVTLFIIKFDGHKKEELLGVANNRIMRMDLNTGDHIKTWRYNTMKAWNVNWGIK 651
            ::|.||:|||||::..:::|.|.:|:|:||:||||::|:||:.||.:||||||||:.|||||.||
Zfish   517 FLQIWQALPDFGLSYIVVRFKGCRKDEVLGIANNRLIRIDLSVGDVVKTWRYNTMRQWNVNWDIK 581

  Fly   652 CMMIQLQ-DENIVFSVQSADCKVVHEFIGGYIFMSMRSKENNQTLNEEMFHKLTGG 706
            .:.|:.. :.||.||..:||||:|||:||||||||.|.::.:.|||||:|||||||
Zfish   582 QVAIEFDGNVNIAFSCVTADCKIVHEYIGGYIFMSTRGRDQSDTLNEELFHKLTGG 637

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fit1NP_647858.2 FERM_F0_kindlins 8..86 CDD:340615 34/80 (43%)
FERM_F1_kindlins 87..299 CDD:340616 62/211 (29%)
B41 <274..>363 CDD:214604 46/88 (52%)
PH_fermitin 401..529 CDD:269943 71/129 (55%)
FERM_M <490..602 CDD:459788 55/112 (49%)
FERM_C_fermitin 596..686 CDD:270026 52/90 (58%)
fermt3aXP_021332356.1 Ubl1_cv_Nsp3_N-like 3..85 CDD:475130 34/80 (43%)
Ubl1_cv_Nsp3_N-like 86..241 CDD:475130 62/211 (29%)
B41 <216..>288 CDD:214604 44/71 (62%)
PH_fermitin 334..458 CDD:269943 71/129 (55%)
FERM_M <429..531 CDD:459788 50/101 (50%)
FERM_C_fermitin 526..617 CDD:270026 52/90 (58%)

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