Protein Alignment Fit1 and fermt2

DIOPT Version :10

• Sequence 1: NP_647858.2
• Gene: Fit1 / 38488
• FlyBaseID: FBgn0035498
• Length: 708
• Species: Drosophila melanogaster
• Sequence 2: XP_031747907.1
• Gene: fermt2 / 100124904
• XenbaseID: XB-GENE-1012566
• Length: 721
• Species: Xenopus tropicalis
• Alignment Length: 729
• Identity: 348/729 - (47%)
• Similarity: 473/729 - (64%)
• Gaps: 73/729 - (10%)

  Fly     6 ENTWNLRILITDLQVEKTLRVKGDQHIGGVMLNLVDP-ELPKDWSDHALWWPAKNIWLTRTRSTL 69
            :.||.|.|.:|||..:.||||.|:.|||||||.||:. ::.||||||||||..|..||.:|..||
 Frog    38 DGTWELNIHVTDLNRDVTLRVTGEVHIGGVMLKLVEKLDVKKDWSDHALWWEKKKTWLLKTHWTL 102

  Fly    70 DQAGVQSDSFLHFTPMHKTLRVQMPDLRYLDYRVNFSAKTFGAVVSLCKDLDIRYPEELSFC-KP 133
            |:.|:|:|:.|.|||.||.||:|:|:::|:..:||||.|.|.||..:||..:||:|||||.. ||
 Frog   103 DKYGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDKVFKAVSDICKTFNIRHPEELSLLRKP 167

  Fly   134 LEPEHLKKNFSKLPQRKI-PVAEANGIAYVQPALDTNS------FVPITGAYNGSNGSLDRSHNG 191
            .:|...||       :|| ...|.|.:....|.|...|      ..|:.|:...|.|...::
 Frog   168 RDPTKKKK-------KKIDDQCEDNILELEGPLLTPGSGTDVLYIGPVKGSIYSSPGLYSKT--- 222

  Fly   192 NLLCAPASPYTRRAATAPGTPISSPTGTWKHNSTGYASYDSNSSFGD--LQEN----LAMSPRSP 250
                     .|....:..|:|: |||..|               |||  |.|.    ||:|....
 Frog   223 ---------MTPTYDSRDGSPL-SPTSAW---------------FGDSALSEGNPGILAVSQPIT 262

  Fly   251 SPDVRARLVRPKSRVEKARLNVGWLDSSLSIMEQGVREYDTLCLRFKYFTFFDLNPKYDQVRINQ 315
            ||::.|::.:|::.::||::|.|||||:.|:|||.|:|.|.|.|||||::|||||||||.:||||
 Frog   263 SPEILAKMYKPQTLLDKAKINQGWLDSARSLMEQDVKENDALLLRFKYYSFFDLNPKYDAIRINQ 327

  Fly   316 LYEQAKWSILNEELEPTEEETLMFAALQFQVNHQTDLHPPGIDSGIDTSSQETGGEDDIDSALNE 380
            |||||||:||.||:|.||||.:||||||:.:|   .|.....::..:.|.:|.   |::|:||::
 Frog   328 LYEQAKWAILLEEIECTEEEMMMFAALQYHIN---KLSVMSSENHYNNSDKEV---DEVDAALSD 386

  Fly   381 LQITLEGPGGGKDQGNITRIPELSDYLKFLKPQRFTLKGYKRYFFTYRDLHLHLYKSQDESRRGA 445
            |:|||||.......|:||.||||:||||..||::.||||||:|:.|::|..:..|||::|| .|.
 Frog   387 LEITLEGGKTSTILGDITSIPELTDYLKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEES-NGT 450

  Fly   446 PTISINLKGCEVTPDVNLAQGKFAIRLEVPSEIRNGPNSEVWVRCDNEEQYAKWMAACRLAAKGR 510
            |...:||:|||||||||::..||.|:|.:|  :..|.| |:|:||:||:|||.||||||||:||:
 Frog   451 PAHQMNLRGCEVTPDVNISGQKFNIKLLIP--VAEGMN-EIWLRCENEKQYAHWMAACRLASKGK 512

  Fly   511 SLADSSYDSEVSSIRSLLQMQ---KPAQGAPLTVNPRSVEPMDYLSPKMMRKLSSK--------A 564
            ::|||||:.||.:|.|.|:||   ...|..|..|| ..:.|...:||:.::|..:|        .
 Frog   513 TMADSSYNLEVQNILSFLKMQHLNPDPQFIPDQVN-SDINPECVVSPRYLKKYKNKQPGYVRDLI 576

  Fly   565 VQRILEAHANVRQLSLMDAKMKYIQAWQSLPDFGVTLFIIKFDGHKKEELLGVANNRIMRMDLNT 629
            ..||||||.||.|:||::|||::||||||||:||:|.|:.:|.|.|||||:|:..||::|||..|
 Frog   577 TARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFLARFQGGKKEELIGITYNRLIRMDAGT 641

  Fly   630 GDHIKTWRYNTMKAWNVNWGIKCMMIQLQDE-NIVFSVQSADCKVVHEFIGGYIFMSMRSKENNQ 693
            ||.|||||::.||.|||||.||.:.::..|| .:.|.....||||||||||||||:|.|:|:.|:
 Frog   642 GDAIKTWRFSNMKQWNVNWEIKMVTVEFADEMRLSFICAEVDCKVVHEFIGGYIFLSTRAKDQNE 706

  Fly   694 TLNEEMFHKLTGGW 707
            :|:||||.|||.||
 Frog   707 SLDEEMFFKLTSGW 720

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fit1	NP_647858.2	FERM_F0_kindlins	8..86	CDD:340615	45/78 (58%)
		FERM_F1_kindlins	87..299	CDD:340616	78/225 (35%)
		B41	<274..>363	CDD:214604	54/88 (61%)
		PH_fermitin	401..529	CDD:269943	71/127 (56%)
		FERM_M	<490..602	CDD:459788	62/122 (51%)
		FERM_C_fermitin	596..686	CDD:270026	51/90 (57%)
fermt2	XP_031747907.1	FERM_F0_KIND2	40..119	CDD:340701	45/78 (58%)
		FERM_F1_KIND2	120..311	CDD:340704	78/225 (35%)
		B41	<278..>358	CDD:214604	56/79 (71%)
		PH_fermitin	407..531	CDD:269943	71/127 (56%)
		FERM_M	<489..614	CDD:459788	64/125 (51%)
		PH-like	608..699	CDD:473070	51/90 (57%)