DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14995 and tilB

DIOPT Version :9

Sequence 1:	NP_728935.1	Gene:	CG14995 / 38487	FlyBaseID:	FBgn0035497	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_608460.1	Gene:	tilB / 33130	FlyBaseID:	FBgn0014395	Length:	395	Species:	Drosophila melanogaster

Alignment Length:	357	Identity:	75/357 - (21%)
Similarity:	133/357 - (37%)	Gaps:	91/357 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSRLTEEMVIARAK---------------QSDLSLIKKLNCWGSDLSDVSI----------IKRM 40
            |..:|||:|..:::               |.|:.:|:.:..|..||..:.:          :.::
  Fly     1 MVLITEELVRKKSEHNERLISTLEEISLHQEDIEVIEHIQNWCRDLKILLLQSNLIARLENLHKL 65

  Fly    41 RGVEVLALSVNKISTLSTFEDCTKLQELYLRKNSISDINEIAYLQNLPSLRNLWLEENPCCERAG 105
            :.:|.|.:::|.|..:...|.|..|.:|.|..|.|.::..:..|....:||.|.|..|||.:.
  Fly    66 KRLEYLNVAINNIERVENLEGCESLSKLDLTLNFIRELTSVESLCGNYNLRELVLIGNPCVDY-- 128

  Fly   106 PNYRSIVLRALPNLKKLDNVEVTQQEVEDALR---GGGVAAPEDEVYEDAYQQQQQSRRSSPQQI 167
            |:||..|:..||.|..||.||:|..|...|||   .......:.:|.:|..:.:|:.|
  Fly   129 PHYRDYVVATLPQLNSLDCVEITPSERLRALRELSKNRSIIVQKQVEQDIERDEQRIR------- 186

  Fly   168 LQQQQHSYPQHSPPPQQQYQQQQQQQQQQQRGCTTPTKEPPQLPSPLVKNSSEGSISHSASDLYQ 232
            :.:||.:..:|....:.:.::.:...|.:...|       |::.:.:.:....|...|.
  Fly   187 VAKQQSALAEHCAGIEDEEERIKAFWQAKSEHC-------PEIRTEIARQHRLGRERHE------ 238

  Fly   233 VQAAQPLKGSQPPTPTKEPVHPPSPMYNTITKEQRTSYHQYDRSPGSDQESSPHTYREVRPTPFP 297
                           ||.|:.|..|        ||..:....|....:|...|..:|:
  Fly   239 ---------------TKSPLDPLKP--------QRNLFAPCGRPYNLNQAKLPFKFRD------- 273

  Fly   298 PSISAHSMKEYYQSDRPAYPAHYRHSQTDLTE 329
                   ..::|......    |||..|.|.:
  Fly   274 -------EADHYLLQLEV----YRHLDTSLID 294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14995	NP_728935.1	leucine-rich repeat	21..42	CDD:275378	4/30 (13%)
		LRR_8	41..99	CDD:290566	16/57 (28%)
		leucine-rich repeat	43..64	CDD:275378	6/20 (30%)
		LRR_4	44..82	CDD:289563	11/37 (30%)
		LRR_RI	<56..>123	CDD:238064	22/66 (33%)
		leucine-rich repeat	65..89	CDD:275378	6/23 (26%)
		leucine-rich repeat	90..118	CDD:275378	12/27 (44%)
tilB	NP_608460.1	LRR_9	1..174	CDD:258718	46/174 (26%)
		leucine-rich repeat	23..45	CDD:275378	4/21 (19%)
		LRR_4	46..86	CDD:289563	5/39 (13%)
		leucine-rich repeat	46..67	CDD:275378	1/20 (5%)
		leucine-rich repeat	68..89	CDD:275378	6/20 (30%)
		leucine-rich repeat	90..114	CDD:275378	6/23 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8601
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.940