DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gad1 and Csad

DIOPT Version :9

Sequence 1:	NP_001261396.1	Gene:	Gad1 / 38484	FlyBaseID:	FBgn0004516	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_068518.1	Gene:	Csad / 60356	RGDID:	621030	Length:	493	Species:	Rattus norvegicus

Alignment Length:	489	Identity:	235/489 - (48%)
Similarity:	333/489 - (68%)	Gaps:	8/489 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 TVTAGPETREFLLK-VIDVLLD--FVKATNDRNEKVLDFHHPEDMKRLLDLDVPDRALPLQQLIE 87
            |:...|...|.||: |..:::|  ..|.|| .:|||.::..||::|:||||::..:....::::|
  Rat     9 TLDGDPVAVEALLRDVFGIVVDEAIRKGTN-ASEKVCEWKEPEELKQLLDLELQSQGESRERILE 72

  Fly    88 DCATTLKYQVKTGHPHFFNQLSNGLDLISMAGEWLTATANTNMFTYEIAPVFILMENVVLTKMRE 152
            .|...:.|.||||||.|||||.:|||..::||..:|.:.||:.:||||||||:|||..||.|:|.
  Rat    73 RCRAVIHYSVKTGHPRFFNQLFSGLDPHALAGRIITESLNTSQYTYEIAPVFVLMEEEVLKKLRA 137

  Fly   153 IIGWSGGDSILAPGGSISNLYAFLAARHKMFPNYKEHGSVGLPGTLVMFTSDQCHYSIKSCAAVC 217
            ::||:.||.:..|||||||:||...||.:.:|:.|:.|...|| .|.:|||.:|||||...||..
  Rat   138 LVGWNTGDGVFCPGGSISNMYAINLARFQRYPDCKQRGLRALP-PLALFTSKECHYSITKGAAFL 201

  Fly   218 GLGTDHCIVVPSDEHGKMITSELERLILERKAKGDIPFFVNATAGTTVLGAFDDINTIADICQKY 282
            |||||...||.:||.||||..:|||.|...:|:|.:||.|:||:|||||||||.::.|||:||::
  Rat   202 GLGTDSVRVVKADERGKMIPEDLERQISLAEAEGSVPFLVSATSGTTVLGAFDPLDAIADVCQRH 266

  Fly   283 NCWMHIDAAWGGGLLMSRKHRHPRFTGVERADSVTWNPHKLMGALLQCSTIHFKE-DGLLISCNQ 346
            ..|:|:||||||.:|:||.||| ...|::|||||.||||||:.|.||||.:..:: ..||..|:.
  Rat   267 GLWLHVDAAWGGSVLLSRTHRH-LLDGIQRADSVAWNPHKLLAAGLQCSALLLRDTSNLLKRCHG 330

  Fly   347 MSAEYLFMTDKQYDISYDTGDKVIQCGRHNDIFKLWLQWRAKGTEGFEQQQDRLMELVQYQLKRI 411
            ..|.|||..||.|:::.||||||:||||..|..||||.|:|:|.:|.|.:.|:...|.:|.::.|
  Rat   331 SQASYLFQQDKFYNVALDTGDKVVQCGRRVDCLKLWLMWKAQGGQGLEWRIDQAFALTRYLVEEI 395

  Fly   412 REQSDRFHLILEPECVNVSFWYVPKRLRGVPHDAKKEVELGKICPIIKGRMMQKGTLMVGYQPDD 476
            ::: :.|.|::|||.|||.||:||..|||..........|.::.|::|.||::|||:|:||||..
  Rat   396 KKR-EGFELVMEPEFVNVCFWFVPPSLRGKKESPDYSQRLSQVAPVLKERMVKKGTMMIGYQPHG 459

  Fly   477 RRPNFFRSIISSAAVNEADVDFMLDEIHRLGDDL 510
            .|.||||.::::..:.:||:||:|.|:.|||.||
  Rat   460 TRANFFRMVVANPILVQADIDFLLGELERLGQDL 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gad1	NP_001261396.1	Pyridoxal_deC	64..434	CDD:395219	188/370 (51%)
Csad	NP_068518.1	DOPA_deC_like	89..489	CDD:99743	201/402 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	85	1.000	Domainoid score	I7988
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62386
OrthoDB	1	1.010	-	-		D162307at33208
OrthoFinder	1	1.000	-	-		FOG0000667
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100596
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X464
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.730