DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gad1 and gad2

DIOPT Version :9

Sequence 1:	NP_001261396.1	Gene:	Gad1 / 38484	FlyBaseID:	FBgn0004516	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001017708.2	Gene:	gad2 / 550403	ZFINID:	ZDB-GENE-030909-9	Length:	583	Species:	Danio rerio

Alignment Length:	498	Identity:	263/498 - (52%)
Similarity:	352/498 - (70%)	Gaps:	8/498 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LTAYDLMPTTVTAGPETREFLLKVIDVLLDFVKATNDRNEKVLDFHHPEDMKRLLDLDVPDRALP 81
            |.:.||:| .:....:|..||.:|:|:||.::..:.||:.||:|||:|.::.:..:.::.|....
Zfish    90 LYSTDLLP-ALDGDAKTMNFLQEVVDILLAYIVESFDRSTKVIDFHYPNELLQRNNWELSDEPET 153

  Fly    82 LQQLIEDCATTLKYQVKTGHPHFFNQLSNGLDLISMAGEWLTATANTNMFTYEIAPVFILMENVV 146
            |..::..|..||||.:||.||.:|||||.|||::.:|.:|||:||||||||||:||||:|:|.|.
Zfish   154 LDDILISCRATLKYAIKTAHPRYFNQLSTGLDMVGLAADWLTSTANTNMFTYEVAPVFVLLEYVT 218

  Fly   147 LTKMREIIGWSG--GDSILAPGGSISNLYAFLAARHKMFPNYKEHGSVGLPGTLVMFTSDQCHYS 209
            |.||||||||..  ||.|.:|||:|||:||.|.||:||||..||.|...:| .||.|||:..|:|
Zfish   219 LKKMREIIGWQDGHGDGIFSPGGAISNMYAMLLARYKMFPEVKEKGMSSVP-RLVAFTSEHSHFS 282

  Fly   210 IKSCAAVCGLGTDHCIVVPSDEHGKMITSELERLILERKAKGDIPFFVNATAGTTVLGAFDDINT 274
            ||..||..|:||:..|.:.:||.||||.|:|||.|:|.|.||.:||||:|||||||.||||.:..
Zfish   283 IKKGAAALGIGTESVICIKADERGKMIPSDLERRIIEAKQKGYVPFFVSATAGTTVYGAFDPLIA 347

  Fly   275 IADICQKYNCWMHIDAAWGGGLLMSRKHRHPRFTGVERADSVTWNPHKLMGALLQCSTIHFKEDG 339
            |||||:|::.|||:|.||||.||||||||. :..|||||:|:||||||:|...||||.:..:|:|
Zfish   348 IADICKKHDVWMHVDGAWGGSLLMSRKHRW-KLNGVERANSMTWNPHKMMAVPLQCSALLVREEG 411

  Fly   340 LLISCNQMSAEYLFMTDKQYDISYDTGDKVIQCGRHNDIFKLWLQWRAKGTEGFEQQQDRLMELV 404
            |:.|||||.|.|||..||.||:.||||||.:|||||.|||||||.||||||.|||.|.|:.:||.
Zfish   412 LMQSCNQMQACYLFQQDKHYDLQYDTGDKALQCGRHVDIFKLWLMWRAKGTIGFEAQIDKCLELS 476

  Fly   405 QYQLKRIREQSDRFHLILE--PECVNVSFWYVPKRLRGVPHDAKKEVELGKICPIIKGRMMQKGT 467
            :|...:|::: :.:.::.:  |:..||.|||:|..:|.:....::...|.|:.|:||.|||:.||
Zfish   477 EYLYNKIKDR-EGYQMVFDGKPQHTNVCFWYLPPGVRYLEDKVERMKRLHKVAPVIKARMMEYGT 540

  Fly   468 LMVGYQPDDRRPNFFRSIISSAAVNEADVDFMLDEIHRLGDDL 510
            .||.|||...:.||||.:||:.|....|:||:::||.|||.||
Zfish   541 TMVSYQPQGDKVNFFRMVISNPAATFEDIDFLIEEIERLGQDL 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gad1	NP_001261396.1	Pyridoxal_deC	64..434	CDD:395219	210/373 (56%)
gad2	NP_001017708.2	Pyridoxal_deC	136..506	CDD:278699	209/372 (56%)
gad2	NP_001017708.2	TIM_phosphate_binding	511..>561	CDD:304361	21/49 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578190
Domainoid	1	1.000	453	1.000	Domainoid score	I485
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	564	1.000	Inparanoid score	I1042
OMA	1	1.010	-	-		QHG62386
OrthoDB	1	1.010	-	-		D162307at33208
OrthoFinder	1	1.000	-	-		FOG0000667
OrthoInspector	1	1.000	-	-		otm24221
orthoMCL	1	0.900	-	-		OOG6_100596
Panther	1	1.100	-	-	O	PTHR45677
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X464
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.770