DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gad1 and csad

DIOPT Version :9

Sequence 1:	NP_001261396.1	Gene:	Gad1 / 38484	FlyBaseID:	FBgn0004516	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	XP_009295318.1	Gene:	csad / 492476	ZFINID:	ZDB-GENE-041114-36	Length:	544	Species:	Danio rerio

Alignment Length:	513	Identity:	227/513 - (44%)
Similarity:	317/513 - (61%)	Gaps:	29/513 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 NGY------KLSERTGKLTAYDLMPTTVTAGPETREFLLKVIDVLL-DFVKATNDRNEKVLDFHH 63
            ||:      .:.|..|||                  ||.:..:::: :.:....|..|||.::..
Zfish    53 NGHVHLEESDMDESDGKL------------------FLTEAFNIIMEEILNKGRDLKEKVCEWKD 99

  Fly    64 PEDMKRLLDLDVPDRALPLQQLIEDCATTLKYQVKTGHPHFFNQLSNGLDLISMAGEWLTATANT 128
            |:.::.||||::.|.....::|::......||.|||.||.|||||..|:|..::.|..:|.|.||
Zfish   100 PDQLRSLLDLELRDHGECHEKLLQRVRDVAKYSVKTCHPRFFNQLFAGVDYHALTGRLITETLNT 164

  Fly   129 NMFTYEIAPVFILMENVVLTKMREIIGWSGGDSILAPGGSISNLYAFLAARHKMFPNYKEHGSVG 193
            :.:|||:||||:|||..|::|:|.::|||.||.|..||||:||:||...||:..||..|..|...
Zfish   165 SQYTYEVAPVFVLMEEEVISKLRSLVGWSEGDGIFCPGGSMSNMYAINVARYWAFPQVKTKGLWA 229

  Fly   194 LPGTLVMFTSDQCHYSIKSCAAVCGLGTDHCIVVPSDEHGKMITSELERLILERKAKGDIPFFVN 258
            .| .:.:|||.|.|||:|..||..|:||::..:|..||.|.||..:||..|::.|::..:|||||
Zfish   230 AP-RMAIFTSQQSHYSVKKGAAFLGIGTENVFIVQVDESGSMIPEDLEAKIVQAKSQDAVPFFVN 293

  Fly   259 ATAGTTVLGAFDDINTIADICQKYNCWMHIDAAWGGGLLMSRKHRHPRFTGVERADSVTWNPHKL 323
            |||||||.||||.:..|||||::...|||:||||||.:|.|:|||| ...|:|||:||||||||:
Zfish   294 ATAGTTVQGAFDPLKRIADICERNGMWMHVDAAWGGSVLFSKKHRH-LVAGIERANSVTWNPHKM 357

  Fly   324 MGALLQCSTIHFKE-DGLLISCNQMSAEYLFMTDKQYDISYDTGDKVIQCGRHNDIFKLWLQWRA 387
            :...||||.|.|:: ..||:.|:...|.|||..||.||.|.|||||.|||||..|..||||.|:|
Zfish   358 LLTGLQCSVILFRDTTNLLMHCHSAKATYLFQQDKFYDTSLDTGDKSIQCGRKVDCLKLWLMWKA 422

  Fly   388 KGTEGFEQQQDRLMELVQYQLKRIREQSDRFHLILEPECVNVSFWYVPKRLRGVPHDAKKEVELG 452
            .|..|..|:.|:...|.:|.::.: |:.:.|.|:.:...|||.||::|..|:|..:....:..|.
Zfish   423 IGASGLSQRVDKAFALTRYLVEEM-EKRENFQLVCKGPFVNVCFWFIPPSLKGKENSPDYQERLS 486

  Fly   453 KICPIIKGRMMQKGTLMVGYQPDDRRPNFFRSIISSAAVNEADVDFMLDEIHRLGDDL 510
            |:.|:||.|||::||:||||||.|...||||.::.|..:...|:||.|||:.:||.||
Zfish   487 KVAPVIKERMMKRGTMMVGYQPMDEHVNFFRMVVVSPQLTTKDMDFFLDEMEKLGKDL 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gad1	NP_001261396.1	Pyridoxal_deC	64..434	CDD:395219	180/370 (49%)
csad	XP_009295318.1	DOPA_deC_like	140..540	CDD:99743	197/402 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	84	1.000	Domainoid score	I8169
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62386
OrthoDB	1	1.010	-	-		D162307at33208
OrthoFinder	1	1.000	-	-		FOG0000667
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100596
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X464
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.730