DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gad1 and GADL1

DIOPT Version :9

Sequence 1:	NP_001261396.1	Gene:	Gad1 / 38484	FlyBaseID:	FBgn0004516	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_997242.2	Gene:	GADL1 / 339896	HGNCID:	27949	Length:	521	Species:	Homo sapiens

Alignment Length:	516	Identity:	232/516 - (44%)
Similarity:	328/516 - (63%)	Gaps:	27/516 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 GKLTAYDLMPT---------TVTAGPET-----REFLLKVIDVLLDFV--KATNDRNEKVLDFHH 63
            |.:...:::|:         .|..||.|     .:|:.:...::::.|  ||| |.||||.::..
Human    13 GDIDQQEMIPSKKNAVLVDGVVLNGPTTDAKAGEKFVEEACRLIMEEVVLKAT-DVNEKVCEWRP 76

  Fly    64 PEDMKRLLDLDVPDRALPLQQLIEDCATTLKYQVKTGHPHFFNQLSNGLDLISMAGEWLTATANT 128
            ||.:|:||||::.|...|..:|:|.|...:.|.|||.||.|||||..|||..|:...::|...|.
Human    77 PEQLKQLLDLEMRDSGEPPHKLLELCRDVIHYSVKTNHPRFFNQLYAGLDYYSLVARFMTEALNP 141

  Fly   129 NMFTYEIAPVFILMENVVLTKMREIIGWSGGDSILAPGGSISNLYAFLAARHKMFPNYKEHGSVG 193
            :::|||::|||:|:|..||.||.|.|||..||.|..||||:||:||...||:|..|:.||.|..|
Human   142 SVYTYEVSPVFLLVEEAVLKKMIEFIGWKEGDGIFNPGGSVSNMYAMNLARYKYCPDIKEKGLSG 206

  Fly   194 LPGTLVMFTSDQCHYSIKSCAAVCGLGTDHCIVVPSDEHGKMITSELERLILERKAKGDIPFFVN 258
            .| .|::|||.:||||:|..|:..|:||::...|.:|..||||..|||:.:.:.:.:|..||.|.
Human   207 SP-RLILFTSAECHYSMKKAASFLGIGTENVCFVETDGRGKMIPEELEKQVWQARKEGAAPFLVC 270

  Fly   259 ATAGTTVLGAFDDINTIADICQKYNCWMHIDAAWGGGLLMSRKHR---HPRFTGVERADSVTWNP 320
            ||:|||||||||.::.|||||::::.|:|:||:|||..|||||||   |    |:.|||||.|||
Human   271 ATSGTTVLGAFDPLDEIADICERHSLWLHVDASWGGSALMSRKHRKLLH----GIHRADSVAWNP 331

  Fly   321 HKLMGALLQCSTIHFKE-DGLLISCNQMSAEYLFMTDKQYDISYDTGDKVIQCGRHNDIFKLWLQ 384
            ||::.|.:||..:..|: ..||..|....|.|||..||.||:|||||||.|||.|..|.||.|:.
Human   332 HKMLMAGIQCCALLVKDKSDLLKKCYSAKASYLFQQDKFYDVSYDTGDKSIQCSRRPDAFKFWMT 396

  Fly   385 WRAKGTEGFEQQQDRLMELVQYQLKRIREQSDRFHLILEPECVNVSFWYVPKRLRGVPHDAKKEV 449
            |:|.||.|.|::.:|.:.|.:|.:..|::: :.|.|::|||..|:.|||:|..||.:....:...
Human   397 WKALGTLGLEERVNRALALSRYLVDEIKKR-EGFKLLMEPEYANICFWYIPPSLREMEEGPEFWA 460

  Fly   450 ELGKICPIIKGRMMQKGTLMVGYQPDDRRPNFFRSIISSAAVNEADVDFMLDEIHRLGDDL 510
            :|..:.|.||.|||:||:||:||||...:.||||.::.|..|:..|:||:||||..||.|:
Human   461 KLNLVAPAIKERMMKKGSLMLGYQPHRGKVNFFRQVVISPQVSREDMDFLLDEIDLLGKDM 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gad1	NP_001261396.1	Pyridoxal_deC	64..434	CDD:395219	181/373 (49%)
GADL1	NP_997242.2	AAT_I	77..445	CDD:302748	181/373 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62386
OrthoDB	1	1.010	-	-		D162307at33208
OrthoFinder	1	1.000	-	-		FOG0000667
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100596
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X464
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.730