DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gad1 and CG1486

DIOPT Version :9

Sequence 1:	NP_001261396.1	Gene:	Gad1 / 38484	FlyBaseID:	FBgn0004516	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_608450.1	Gene:	CG1486 / 33108	FlyBaseID:	FBgn0031174	Length:	852	Species:	Drosophila melanogaster

Alignment Length:	587	Identity:	113/587 - (19%)
Similarity:	201/587 - (34%)	Gaps:	194/587 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NPNGYKLSERTG-KLTAYDLMPTTVTAGPETREFLLKVIDVLLDFVKATNDRNEKVLDFHHPEDM 67
            :||..:..|..| ::|:.||:|    |.......:||.::.|:.:..:.:|          ||..
  Fly    67 SPNPVENEEEAGERVTSEDLLP----AKHRVPSDILKSLEQLVSYTDSDDD----------PEFP 117

  Fly    68 KRLLDLDVPDRALPLQQLIEDCATTLKYQVKTGHPHFFNQLSNGLDLISMAGE---WLTATANTN 129
            ...|| ||...||....::...:...:.|:.        :::|     |::|:   ||....:
  Fly   118 LPALD-DVSHLALISHSIVAYLSHLDRQQLL--------RVTN-----SISGDATRWLGTLFH-- 166

  Fly   130 MFTYEIAPVFILMENVVLTKMREIIGWSGGDSILAPGGSISNLYAFLAARHKMFPNYKEHGSVGL 194
             |.:..:.......:.||..:|           ||           :.||   .|.|.|.|...|
  Fly   167 -FAHPASSFHADNADAVLRTVR-----------LA-----------IVAR---CPGYLEGGIPAL 205

  Fly   195 PGTLVMFTSD----QCHYSIKSCAAVCGLGTDHCIVVPSDEHGKMITSELERLILERKAKGDI-- 253
            .......:.:    :.||:.:.    .|:..:...|:|  ||.:..|.::  .:|:::.:.|:
  Fly   206 AQPTFYISENTTPMRLHYACRQ----LGIPLEAIKVIP--EHSQSGTMDV--TLLQKQIQQDVGN 262

  Fly   254 ---PFFVNATAGTTVLGAFDDINTIADICQKYNCWMHIDAAWGGGLLMSRKHRHPRFTGVERADS 315
               |..|.|..|.::.|..|::..:.|:|:.:|.|:|........|:.::...|..    |...|
  Fly   263 NRTPLLVVADIGASLCGYVDNLLRLRDVCKAHNMWLHASGHGLAALVCAQNQGHVE----EVLHS 323

  Fly   316 VTWN----------PHKLMGALLQCSTIH-FKEDGLLI-SCNQMS-------------AEYLFMT 355
            :..|          |..|:...||.|.:. |:.|.:|. ..|.:|             ||.|.:.
  Fly   324 MALNLGSWLGVPSLPIVLLHRPLQNSALSAFESDPILSRRLNALSLWTSLQALGRKAIAERLHVA 388

  Fly   356 DKQYDISYDTGDKV-----------IQCGRH-NDIFKLWLQWRAKGTEGFEQQQ--DRLMELVQY 406
            .:...|.::...|.           .|.|.. :|:.:          ..|:.|.  |....:|.|
  Fly   389 FQTCSILFEIASKCEGIRVLSHTPGAQTGASLSDVIQ----------SPFDVQALFDAAAPVVAY 443

  Fly   407 Q-------------------------------LKRIREQS--DRFH----LILEPECVNVSFWYV 434
            |                               |::|...|  ||.:    .||:.:|.|..|..:
  Fly   444 QFDGSTTIPLGGSGSSAAAAAAERETAEGLKPLEKINNASYFDRLNSWLGQILQRDCPNFDFEVI 508

  Fly   435 PKRLRGVPHDAKKEVELGKICPIIKGRMMQKGTLMVGYQP--DDRRPNFFRSIISSAAVNEADVD 497
            .....|         ...:.||:..|         :|.||  .:...:|.:|:       ||.||
  Fly   509 EHPTHG---------SCIRYCPLELG---------LGEQPPSSENLESFAQSL-------EAHVD 548

  Fly   498 FM 499
            .:
  Fly   549 IL 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gad1	NP_001261396.1	Pyridoxal_deC	64..434	CDD:395219	87/457 (19%)
CG1486	NP_608450.1	AAT_I	159..>384	CDD:302748	52/264 (20%)
CG1486	NP_608450.1	WWbp	<725..801	CDD:304964
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445342
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840