DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gad1 and GAD1

DIOPT Version :9

Sequence 1:	NP_001261396.1	Gene:	Gad1 / 38484	FlyBaseID:	FBgn0004516	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_000808.2	Gene:	GAD1 / 2571	HGNCID:	4092	Length:	594	Species:	Homo sapiens

Alignment Length:	501	Identity:	288/501 - (57%)
Similarity:	367/501 - (73%)	Gaps:	11/501 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LTAYDLMPTTVTAGPETREFLLKVIDVLLDFVKATNDRNEKVLDFHHPEDMKRLLD---LDVPDR 78
            |.|.||:|.. ....:|.:|||:|:|:||::|:.|.||:.||||||||..:...::   |::.|.
Human    98 LFARDLLPAK-NGEEQTVQFLLEVVDILLNYVRKTFDRSTKVLDFHHPHQLLEGMEGFNLELSDH 161

  Fly    79 ALPLQQLIEDCATTLKYQVKTGHPHFFNQLSNGLDLISMAGEWLTATANTNMFTYEIAPVFILME 143
            ...|:|::.||..||||.|:||||.||||||.|||:|.:||||||:|||||||||||||||:|||
Human   162 PESLEQILVDCRDTLKYGVRTGHPRFFNQLSTGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLME 226

  Fly   144 NVVLTKMREIIGWSG--GDSILAPGGSISNLYAFLAARHKMFPNYKEHGSVGLPGTLVMFTSDQC 206
            .:.|.|||||:|||.  ||.|.:|||:|||:|:.:|||:|.||..|..|...:| .||:|||:|.
Human   227 QITLKKMREIVGWSSKDGDGIFSPGGAISNMYSIMAARYKYFPEVKTKGMAAVP-KLVLFTSEQS 290

  Fly   207 HYSIKSCAAVCGLGTDHCIVVPSDEHGKMITSELERLILERKAKGDIPFFVNATAGTTVLGAFDD 271
            |||||...|..|.|||:.|::..:|.||:|.::.|..|||.|.||.:||:|||||||||.||||.
Human   291 HYSIKKAGAALGFGTDNVILIKCNERGKIIPADFEAKILEAKQKGYVPFYVNATAGTTVYGAFDP 355

  Fly   272 INTIADICQKYNCWMHIDAAWGGGLLMSRKHRHPRFTGVERADSVTWNPHKLMGALLQCSTIHFK 336
            |..|||||:|||.|:|:|||||||||||||||| :..|:|||:||||||||:||.|||||.|..|
Human   356 IQEIADICEKYNLWLHVDAAWGGGLLMSRKHRH-KLNGIERANSVTWNPHKMMGVLLQCSAILVK 419

  Fly   337 EDGLLISCNQMSAEYLFMTDKQYDISYDTGDKVIQCGRHNDIFKLWLQWRAKGTEGFEQQQDRLM 401
            |.|:|..||||.|.|||..|||||:|||||||.||||||.||||.||.|:||||.|||.|.::.:
Human   420 EKGILQGCNQMCAGYLFQPDKQYDVSYDTGDKAIQCGRHVDIFKFWLMWKAKGTVGFENQINKCL 484

  Fly   402 ELVQYQLKRIREQSDRFHLIL--EPECVNVSFWYVPKRLRGVPHDAKKEVELGKICPIIKGRMMQ 464
            ||.:|...:|:.: :.|.::.  |||..||.|||:|:.|||||...::..:|.|:.|.||..||:
Human   485 ELAEYLYAKIKNR-EEFEMVFNGEPEHTNVCFWYIPQSLRGVPDSPQRREKLHKVAPKIKALMME 548

  Fly   465 KGTLMVGYQPDDRRPNFFRSIISSAAVNEADVDFMLDEIHRLGDDL 510
            .||.||||||...:.||||.:||:.|..::|:||:::||.|||.||
Human   549 SGTTMVGYQPQGDKANFFRMVISNPAATQSDIDFLIEEIERLGQDL 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gad1	NP_001261396.1	Pyridoxal_deC	64..434	CDD:395219	225/376 (60%)
GAD1	NP_000808.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Pyridoxal_deC	144..518	CDD:365998	225/376 (60%)
		Substrate binding	190..192		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144948
Domainoid	1	1.000	472	1.000	Domainoid score	I450
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H635
Inparanoid	1	1.050	595	1.000	Inparanoid score	I973
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62386
OrthoDB	1	1.010	-	-		D162307at33208
OrthoFinder	1	1.000	-	-		FOG0000667
OrthoInspector	1	1.000	-	-		otm40889
orthoMCL	1	0.900	-	-		OOG6_100596
Panther	1	1.100	-	-	O	PTHR45677
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4534
SonicParanoid	1	1.000	-	-		X464
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800