DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gad1 and Csad

DIOPT Version :9

Sequence 1:	NP_001261396.1	Gene:	Gad1 / 38484	FlyBaseID:	FBgn0004516	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001346055.1	Gene:	Csad / 246277	MGIID:	2180098	Length:	493	Species:	Mus musculus

Alignment Length:	489	Identity:	235/489 - (48%)
Similarity:	335/489 - (68%)	Gaps:	8/489 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 TVTAGPETREFLLK-VIDVLLD--FVKATNDRNEKVLDFHHPEDMKRLLDLDVPDRALPLQQLIE 87
            |:...|...|.||: |..:::|  .:|.|: .:|||.::..||::|:||||::..:....:|::|
Mouse     9 TLDGDPVAVEALLQDVFGIVVDEAILKGTS-ASEKVCEWKEPEELKQLLDLELQSQGESREQILE 72

  Fly    88 DCATTLKYQVKTGHPHFFNQLSNGLDLISMAGEWLTATANTNMFTYEIAPVFILMENVVLTKMRE 152
            .|.|.:.|.||||||.|||||.:|||..::||..:|.:.||:.:||||||||:|||..||.|:|.
Mouse    73 RCRTVIHYSVKTGHPRFFNQLFSGLDPHALAGRIITESLNTSQYTYEIAPVFVLMEEEVLKKLRA 137

  Fly   153 IIGWSGGDSILAPGGSISNLYAFLAARHKMFPNYKEHGSVGLPGTLVMFTSDQCHYSIKSCAAVC 217
            ::||:.||.:..|||||||:||...||.:.:|:.|:.|...|| .|.:|||.:|||||...||..
Mouse   138 LVGWNSGDGVFCPGGSISNMYAMNLARFQRYPDCKQRGLRALP-PLALFTSKECHYSITKGAAFL 201

  Fly   218 GLGTDHCIVVPSDEHGKMITSELERLILERKAKGDIPFFVNATAGTTVLGAFDDINTIADICQKY 282
            |||||...||.:||.|:||..:|||.|:..:|:|.:||.|:||:|||||||||.::.|||:||::
Mouse   202 GLGTDSVRVVKADERGRMIPEDLERQIILAEAEGSVPFLVSATSGTTVLGAFDPLDAIADVCQRH 266

  Fly   283 NCWMHIDAAWGGGLLMSRKHRHPRFTGVERADSVTWNPHKLMGALLQCSTIHFKE-DGLLISCNQ 346
            ..|.|:||||||.:|:||.||| ...|::|||||.||||||:.|.||||.:..:: ..||..|:.
Mouse   267 GLWFHVDAAWGGSVLLSRTHRH-LLDGIQRADSVAWNPHKLLAAGLQCSALLLRDTSNLLKRCHG 330

  Fly   347 MSAEYLFMTDKQYDISYDTGDKVIQCGRHNDIFKLWLQWRAKGTEGFEQQQDRLMELVQYQLKRI 411
            ..|.|||..||.||::.||||||:||||..|..||||.|:|:|.:|.|::.|:...|.:|.::.|
Mouse   331 SQASYLFQQDKFYDVALDTGDKVVQCGRRVDCLKLWLMWKAQGGQGLERRIDQAFALTRYLVEEI 395

  Fly   412 REQSDRFHLILEPECVNVSFWYVPKRLRGVPHDAKKEVELGKICPIIKGRMMQKGTLMVGYQPDD 476
            ::: :.|.|::|||.|||.||:||..|||..........|.::.|::|.||::|||:|:||||..
Mouse   396 KKR-EGFELVMEPEFVNVCFWFVPPSLRGKKESPDYSQRLSQVAPVLKERMVKKGTMMIGYQPHG 459

  Fly   477 RRPNFFRSIISSAAVNEADVDFMLDEIHRLGDDL 510
            .|.||||.::::..:.:||:||:|.|:..||.||
Mouse   460 TRANFFRMVVANPILAQADIDFLLGELELLGQDL 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gad1	NP_001261396.1	Pyridoxal_deC	64..434	CDD:395219	190/370 (51%)
Csad	NP_001346055.1	DOPA_deC_like	89..481	CDD:99743	197/394 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62386
OrthoDB	1	1.010	-	-		D162307at33208
OrthoFinder	1	1.000	-	-		FOG0000667
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100596
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X464
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.730