DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gad1 and Ddc

DIOPT Version :9

Sequence 1:	NP_001261396.1	Gene:	Gad1 / 38484	FlyBaseID:	FBgn0004516	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001257781.1	Gene:	Ddc / 24311	RGDID:	2494	Length:	480	Species:	Rattus norvegicus

Alignment Length:	505	Identity:	129/505 - (25%)
Similarity:	202/505 - (40%)	Gaps:	58/505 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 ETREFLLK---VIDVLLDFVKATNDRNEKVLDFHHPEDMKRLLDLDVPDRALPLQQLIEDCATTL 93
            ::|||..:   ::|.:.|::.....|  .|.....|..::.|:....|......:.:|.|....:
  Rat     2 DSREFRRRGKEMVDYIADYLDGIEGR--PVYPDVEPGYLRALIPTTAPQEPETYEDIIRDIEKII 64

  Fly    94 KYQVKTGH-PHFFNQLSNGLDLISMAGEWLTATANTNMFTYEIAPVFILMENVV---LTKMRE-- 152
            ...|...| |:||..........:|..:.|........|::..:|....:|.|:   |.||.|
  Rat    65 MPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMDWLGKMLELP 129

  Fly   153 ---IIGWSG-GDSILAPGGSISNLYAFLAARHKMFPNYK----EHGSVGLPGTLVMFTSDQCHYS 209
               :.|.:| |..::....|.:.|.|.||||.||....:    |.....|...||.:||||.|.|
  Rat   130 EAFLAGRAGEGGGVIQGSASEATLVALLAARTKMIRQLQAASPELTQAALMEKLVAYTSDQAHSS 194

  Fly   210 IKSCAAVCGLGTDHCIVVPSDEHGKMITSELERLILERKAKGDIPFFVNATAGTTVLGAFDDINT 274
            ::....:.|:...   .:|||.:..|..:.|...:...||.|.|||||..|.|||...:||::..
  Rat   195 VERAGLIGGVKIK---AIPSDGNYSMRAAALREALERDKAAGLIPFFVVVTLGTTSCCSFDNLLE 256

  Fly   275 IADICQKYNCWMHIDAAWGGGLLMSRKHRHPRFTGVERADSVTWNPHKLMGALLQCSTIHFKEDG 339
            :..||.:...|:|||||:.|...:..:.|: ...|||.|||..:||||.:.....||.:..|:..
  Rat   257 VGPICNQEGVWLHIDAAYAGSAFICPEFRY-LLNGVEFADSFNFNPHKWLLVNFDCSAMWVKKRT 320

  Fly   340 LLISCNQMSAEYLFMTDKQYDISYDTGDKVIQCGRHNDIFKLWLQWRAKGTEGFEQQQDRLMELV 404
            .|.....|...||..:.:...:..|.....|..||.....|:|..:|..|.:|.:....:.::|
  Rat   321 DLTEAFNMDPVYLRHSHQDSGLITDYRHWQIPLGRRFRSLKMWFVFRMYGVKGLQAYIRKHVKL- 384

  Fly   405 QYQLKRIREQSDRFHLILEPECVNVSFWYVPKRLRGVPHDAKKEVELGKICPIIKGRMMQKGTLM 469
            .::.:.:..|..||.:     |.                    ||.||.:|..:||......||:
  Rat   385 SHEFESLVRQDPRFEI-----CT--------------------EVILGLVCFRLKGSNQLNETLL 424

  Fly   470 --------VGYQPDDRRPNF-FRSIISSAAVNEADVDFMLDEIHRLGDDL 510
                    :...|...|..| .|..:.|..|..|.|....:.|..|...:
  Rat   425 QRINSAKKIHLVPCRLRDKFVLRFAVCSRTVESAHVQLAWEHIRDLASSV 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gad1	NP_001261396.1	Pyridoxal_deC	64..434	CDD:395219	103/383 (27%)
Ddc	NP_001257781.1	Pyridoxal_deC	35..414	CDD:278699	108/408 (26%)
Ddc	NP_001257781.1	2 X approximate tandem repeats	58..178		29/119 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810