Protein Alignment Gad1 and DDC

DIOPT Version :10

• Sequence 1: NP_523914.2
• Gene: Gad1 / 38484
• FlyBaseID: FBgn0004516
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: XP_047275888.1
• Gene: DDC / 1644
• HGNCID: 2719
• Length: 521
• Species: Homo sapiens
• Alignment Length: 538
• Identity: 125/538 - (23%)
• Similarity: 203/538 - (37%)
• Gaps: 100/538 - (18%)

  Fly    39 KVIDVLLDFVKATNDRNEKVLDFHHPEDMKRLLDLDVPDRALPLQQLIEDCATTLKYQVKTGH-P 102
            :::|.:.::::....|  :|.....|..::.|:....|......:.:|.|....:...|...| |
Human    12 EMVDYMANYMEGIEGR--QVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDVEKIIMPGVTHWHSP 74

  Fly   103 HFFNQLSNGLDLISMAGEWLTATANTNMFTY---------------------------------- 133
            :||..........:|..:.|........|::
Human    75 YFFAYFPTASSYPAMLADMLCGAIGCIGFSWGCCLGRGSNQPIRCVQSLGAGGSLEKGLAPACKP 139

  Fly   134 -------EIAPVFILMENVV---LTKMREI--------IGWSGGDSILAPGGSISNLYAFLAAR- 179
                   ..:|....:|.|:   |.||.|:        .|..||  ::....|.:.|.|.||||
Human   140 PVPPYLEAASPACTELETVMMDWLGKMLELPKAFLNEKAGEGGG--VIQGSASEATLVALLAART 202

  Fly   180 ---HKMFPNYKEHGSVGLPGTLVMFTSDQCHYSIKSCAAVCGLGTDHCIVVPSDEHGKMITSELE 241
               |::.....|.....:...||.::|||.|.|::....:.|:...   .:|||.:..|..|.|:
Human   203 KVIHRLQAASPELTQAAIMEKLVAYSSDQAHSSVERAGLIGGVKLK---AIPSDGNFAMRASALQ 264

  Fly   242 RLILERKAKGDIPFFVNATAGTTVLGAFDDINTIADICQKYNCWMHIDAAWGGGLLMSRKHRHPR 306
            ..:...||.|.||||:.||.|||...:||::..:..||.|.:.|:|:|||:.|...:..:.|| .
Human   265 EALERDKAAGLIPFFMVATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFICPEFRH-L 328

  Fly   307 FTGVERADSVTWNPHKLMGALLQCSTIHFKEDGLLISCNQMSAEYLFMTDKQYDISYDTGDKVIQ 371
            ..|||.|||..:||||.:.....||.:..|:...|....::...||..:.:...:..|.....|.
Human   329 LNGVEFADSFNFNPHKWLLVNFDCSAMWVKKRTDLTGAFRLDPTYLKHSHQDSGLITDYRHWQIP 393

  Fly   372 CGRHNDIFKLWLQWRAKGTEGFEQQQDRLMELVQYQLKRIREQSDRFHLILEPECVNVSFWYVPK 436
            .||.....|:|..:|..|.:|.:....:.::| .::.:.:..|..||.:     ||
Human   394 LGRRFRSLKMWFVFRMYGVKGLQAYIRKHVQL-SHEFESLVRQDPRFEI-----CV--------- 443

  Fly   437 RLRGVPHDAKKEVELGKICPIIKGRMMQKGTLM--------VGYQPDDRRPNF-FRSIISSAAVN 492
                       ||.||.:|..:||.......|:        :...|...|..| .|..|.|..|.
Human   444 -----------EVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVE 497

  Fly   493 EADVDFMLDEIHRLGDDL 510
            .|.|....:.|..|..|:
Human   498 SAHVQRAWEHIKELAADV 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gad1	NP_523914.2	Pyridoxal_deC	64..434	CDD:395219	102/426 (24%)
DDC	XP_047275888.1	Pyridoxal_deC	35..455	CDD:395219	107/451 (24%)