DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gad1 and Gad2

DIOPT Version :9

Sequence 1:	NP_001261396.1	Gene:	Gad1 / 38484	FlyBaseID:	FBgn0004516	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_032104.2	Gene:	Gad2 / 14417	MGIID:	95634	Length:	585	Species:	Mus musculus

Alignment Length:	498	Identity:	272/498 - (54%)
Similarity:	357/498 - (71%)	Gaps:	8/498 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LTAYDLMPTTVTAGPETREFLLKVIDVLLDFVKATNDRNEKVLDFHHPEDMKRLLDLDVPDRALP 81
            |.|.||:|......| |..||..|:::||.:|..:.||:.||:|||:|.::.:..:.::.|:...
Mouse    92 LHATDLLPACDGERP-TLAFLQDVMNILLQYVVKSFDRSTKVIDFHYPNELLQEYNWELADQPQN 155

  Fly    82 LQQLIEDCATTLKYQVKTGHPHFFNQLSNGLDLISMAGEWLTATANTNMFTYEIAPVFILMENVV 146
            |::::..|.|||||.:|||||.:|||||.|||::.:|.:|||:|||||||||||||||:|:|.|.
Mouse   156 LEEILTHCQTTLKYAIKTGHPRYFNQLSTGLDMVGLAADWLTSTANTNMFTYEIAPVFVLLEYVT 220

  Fly   147 LTKMREIIGWSG--GDSILAPGGSISNLYAFLAARHKMFPNYKEHGSVGLPGTLVMFTSDQCHYS 209
            |.||||||||.|  ||.|.:|||:|||:||.|.||:||||..||.|...:| .|:.|||:..|:|
Mouse   221 LKKMREIIGWPGGSGDGIFSPGGAISNMYAMLIARYKMFPEVKEKGMAAVP-RLIAFTSEHSHFS 284

  Fly   210 IKSCAAVCGLGTDHCIVVPSDEHGKMITSELERLILERKAKGDIPFFVNATAGTTVLGAFDDINT 274
            :|..||..|:|||..|::..||.||||.|:|||.|||.|.||.:||.|:|||||||.||||.:..
Mouse   285 LKKGAAALGIGTDSVILIKCDERGKMIPSDLERRILEVKQKGFVPFLVSATAGTTVYGAFDPLLA 349

  Fly   275 IADICQKYNCWMHIDAAWGGGLLMSRKHRHPRFTGVERADSVTWNPHKLMGALLQCSTIHFKEDG 339
            :||||:||..|||:||||||||||||||:. :.:|||||:||||||||:||..||||.:..:|:|
Mouse   350 VADICKKYKIWMHVDAAWGGGLLMSRKHKW-KLSGVERANSVTWNPHKMMGVPLQCSALLVREEG 413

  Fly   340 LLISCNQMSAEYLFMTDKQYDISYDTGDKVIQCGRHNDIFKLWLQWRAKGTEGFEQQQDRLMELV 404
            |:.|||||.|.|||..||.||:|||||||.:|||||.|:|||||.||||||.|||...|:.:||.
Mouse   414 LMQSCNQMHASYLFQQDKHYDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGFEAHIDKCLELA 478

  Fly   405 QYQLKRIREQSDRFHLILE--PECVNVSFWYVPKRLRGVPHDAKKEVELGKICPIIKGRMMQKGT 467
            :| |..|.:..:.:.::.:  |:..||.||:||..||.:..:.::...|.|:.|:||.|||:.||
Mouse   479 EY-LYTIIKNREGYEMVFDGKPQHTNVCFWFVPPSLRTLEDNEERMSRLSKVAPVIKARMMEYGT 542

  Fly   468 LMVGYQPDDRRPNFFRSIISSAAVNEADVDFMLDEIHRLGDDL 510
            .||.|||...:.||||.:||:.|....|:||:::||.|||.||
Mouse   543 TMVSYQPLGDKVNFFRMVISNPAATHQDIDFLIEEIERLGQDL 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gad1	NP_001261396.1	Pyridoxal_deC	64..434	CDD:395219	216/373 (58%)
Gad2	NP_032104.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Pyridoxal_deC	138..509	CDD:278699	216/373 (58%)
		Substrate binding. /evidence=ECO:0000250	181..183		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835050
Domainoid	1	1.000	468	1.000	Domainoid score	I459
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	591	1.000	Inparanoid score	I980
Isobase	1	0.950	-	0	Normalized mean entropy	S2794
OMA	1	1.010	-	-		QHG62386
OrthoDB	1	1.010	-	-		D162307at33208
OrthoFinder	1	1.000	-	-		FOG0000667
OrthoInspector	1	1.000	-	-		otm42962
orthoMCL	1	0.900	-	-		OOG6_100596
Panther	1	1.100	-	-	O	PTHR45677
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X464
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.720